Open Access

Discrepancy between the effects of morronside on apoptosis in human embryonic lung fibroblast cells and lung cancer A549 cells

  • Authors:
    • Jian‑Ping Chen
    • De‑Guo Xu
    • Xiao‑Yi Yu
    • Feng‑Ming Zhao
    • Dong‑Qing Xu
    • Xu Zhang
    • Bao‑Chang Cai
    • Ming‑Yan Wang
  • View Affiliations

  • Published online on: February 3, 2014     https://doi.org/10.3892/ol.2014.1850
  • Pages: 927-932
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Abstract

Morroniside is a water‑soluble compound extracted from the fruit of Cornus officinalis and is used to protect lung activity against aging. In the present study, the manner in which morroniside regulates normal lung and cancer cells was examined. The human embryonic lung fibroblast (HELF) cell line and lung cancer A549 cell line, and their responses to morroniside treatment, were examined. Results showed that morroniside reverses the apoptotic effect of H2O2 on HELF cell growth, protecting cell proliferation and normal cell morphology and inhibiting apoptosis. However, these effects were not present in A549 cells. Western blotting showed that morroniside also markedly downregulated retinoblastoma protein in HELF cells. These results suggest that morroniside treatment exhibits different effects on apoptosis in HELF and A549 cells, making it a viable compound for decreasing the side effects of anticancer medicines in normal cells.
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2014-April
Volume 7 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Chen JP, Xu DG, Yu XY, Zhao FM, Xu DQ, Zhang X, Cai BC and Wang MY: Discrepancy between the effects of morronside on apoptosis in human embryonic lung fibroblast cells and lung cancer A549 cells. Oncol Lett 7: 927-932, 2014
APA
Chen, J., Xu, D., Yu, X., Zhao, F., Xu, D., Zhang, X. ... Wang, M. (2014). Discrepancy between the effects of morronside on apoptosis in human embryonic lung fibroblast cells and lung cancer A549 cells. Oncology Letters, 7, 927-932. https://doi.org/10.3892/ol.2014.1850
MLA
Chen, J., Xu, D., Yu, X., Zhao, F., Xu, D., Zhang, X., Cai, B., Wang, M."Discrepancy between the effects of morronside on apoptosis in human embryonic lung fibroblast cells and lung cancer A549 cells". Oncology Letters 7.4 (2014): 927-932.
Chicago
Chen, J., Xu, D., Yu, X., Zhao, F., Xu, D., Zhang, X., Cai, B., Wang, M."Discrepancy between the effects of morronside on apoptosis in human embryonic lung fibroblast cells and lung cancer A549 cells". Oncology Letters 7, no. 4 (2014): 927-932. https://doi.org/10.3892/ol.2014.1850