Pancreatic body adenocarcinoma with neuroendocrine tumor characteristics: A case report

Tajima,Hidehiro; Kitagawa,Hirohisa; Shoji,Masatoshi; Watanabe,Toshifumi; Nakanuma,Shinichi; Okamoto,Koichi; Sakai,Seisho; Kinoshita,Jun; Makino,Isamu; Furukawa,Hiroyuki; Nakamura,Keishi; Hayashi,Hironori; Oyama,Katsunobu; Inokuchi,Masafumi; Nakagawara,Hisatoshi; Miyashita,Tomoharu; Itoh,Hiroshi; Takamura,Hiroyuki; Ninomiya,Itasu; Fushida,Sachio; Fujimura,Takashi; Ohta,Tetsuo; Satoh,Hirohide; Ikeda,Hiroko; Harada,Kenichi; Nakanuma,Yasuni

doi:10.3892/ol.2014.1873

2014-April Volume 7 Issue 4

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2014-April Volume 7 Issue 4

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Case Report

Pancreatic body adenocarcinoma with neuroendocrine tumor characteristics: A case report

Authors:
- Hidehiro Tajima
- Hirohisa Kitagawa
- Masatoshi Shoji
- Toshifumi Watanabe
- Shinichi Nakanuma
- Koichi Okamoto
- Seisho Sakai
- Jun Kinoshita
- Isamu Makino
- Hiroyuki Furukawa
- Keishi Nakamura
- Hironori Hayashi
- Katsunobu Oyama
- Masafumi Inokuchi
- Hisatoshi Nakagawara
- Tomoharu Miyashita
- Hiroshi Itoh
- Hiroyuki Takamura
- Itasu Ninomiya
- Sachio Fushida
- Takashi Fujimura
- Tetsuo Ohta
- Hirohide Satoh
- Hiroko Ikeda
- Kenichi Harada
- Yasuni Nakanuma
View Affiliations / Copyright

Affiliations: Department of Gastroenterologic Surgery, Division of Cancer Medicine, Graduate School of Medicine Science, Kanazawa University, Kanazawa, Ishikawa 920‑8641, Japan, Division of Pathology, Kanazawa University Hospital, Kanazawa, Ishikawa 920‑8641, Japan, Department of Human Pathology, Division of Cancer Medicine, Graduate School of Medicine Science, Kanazawa University, Kanazawa, Ishikawa 920‑8641, Japan
Pages: 1049-1052
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Published online on: February 12, 2014

https://doi.org/10.3892/ol.2014.1873
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Abstract

A 61‑year‑old female with pancreatic body cancer underwent a distal pancreatectomy. The tumor was a moderately‑ to poorly‑differentiated adenocarcinoma. Tumor growth filled the dilated main pancreatic duct (MPD) and infiltrated the surrounding area. Six months later, metastases to the left diaphragm and MPD of the remnant pancreatic head were detected. Chemoradiotherapy was administered, but the patient succumbed 22 months after surgery. An autopsy demonstrated that a moderately‑ to poorly‑differentiated adenocarcinoma had arisen from the pancreatic head and infiltrated the duodenum and bile duct. Huge liver metastases and multiple peritoneal disseminations were also present. Microscopically, a portion of the tumor had a pseudo‑rosette appearance in the adenocarcinoma component, while another section showed characteristics of a neuroendocrine tumor (NET) immunohistochemically. The original surgically‑resected tumor also showed NET characteristics immunohistochemically. It is therefore necessary to search for NET components in pancreatic cancer with atypical growth and metastases, even when adenocarcinoma has been diagnosed histologically.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Pancreatic body adenocarcinoma with neuroendocrine tumor characteristics: A case report

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Abstract

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