Open Access

Magnetic fluid hyperthermia inhibits the growth of breast carcinoma and downregulates vascular endothelial growth factor expression

  • Authors:
    • Guihua Wang
    • Derong Xu
    • Qin Chai
    • Xiaolang Tan
    • Yu Zhang
    • Ning Gu
    • Jintian Tang
  • View Affiliations

  • Published online on: February 20, 2014     https://doi.org/10.3892/ol.2014.1893
  • Pages: 1370-1374
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Abstract

The application of magnetic fluid hyperthermia (MFH) with nanoparticles has been shown to inhibit tumor growth in several animal models. However, the feasibility of using MFH in vivo to treat breast cancer is uncertain, and the mechanism is unclear. In the present study, it was observed that the intratumoral administration of MFH induced hyperthermia significantly in rats with Walker‑265 breast carcinomas. The hyperthermia treatment with magnetic nanoparticles inhibited tumor growth in vivo and promoted the survival of the tumor‑bearing rats. Furthermore, it was found that MFH treatment downregulated the protein expression of vascular endothelial growth factor (VEGF) in the tumor tissue, as observed by immunohistochemistry. MFH treatment also decreased the gene expression of VEGF and its receptors, VEGF receptor 1 and 2, and inhibited angiogenesis in the tumor tissues. Taken together, these results indicate that the application of MFH with nanoparticles is feasible for the treatment of breast carcinoma. The MFH‑induced downregulation of angiogenesis may also contribute to the induction of an anti‑tumor effect.
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May-2014
Volume 7 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wang G, Xu D, Chai Q, Tan X, Zhang Y, Gu N and Tang J: Magnetic fluid hyperthermia inhibits the growth of breast carcinoma and downregulates vascular endothelial growth factor expression. Oncol Lett 7: 1370-1374, 2014
APA
Wang, G., Xu, D., Chai, Q., Tan, X., Zhang, Y., Gu, N., & Tang, J. (2014). Magnetic fluid hyperthermia inhibits the growth of breast carcinoma and downregulates vascular endothelial growth factor expression. Oncology Letters, 7, 1370-1374. https://doi.org/10.3892/ol.2014.1893
MLA
Wang, G., Xu, D., Chai, Q., Tan, X., Zhang, Y., Gu, N., Tang, J."Magnetic fluid hyperthermia inhibits the growth of breast carcinoma and downregulates vascular endothelial growth factor expression". Oncology Letters 7.5 (2014): 1370-1374.
Chicago
Wang, G., Xu, D., Chai, Q., Tan, X., Zhang, Y., Gu, N., Tang, J."Magnetic fluid hyperthermia inhibits the growth of breast carcinoma and downregulates vascular endothelial growth factor expression". Oncology Letters 7, no. 5 (2014): 1370-1374. https://doi.org/10.3892/ol.2014.1893