Autophagy: A novel therapeutic target for hepatocarcinoma (Review)

Wang,Zhanggui; Han,Weidong; Sui,Xinbing; Fang,Yong; Pan,Hongming

doi:10.3892/ol.2014.1916

Autophagy: A novel therapeutic target for hepatocarcinoma (Review)

Authors:
- Zhanggui Wang
- Weidong Han
- Xinbing Sui
- Yong Fang
- Hongming Pan
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Affiliations: Department of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang 310016, P.R. China
Published online on: February 26, 2014 https://doi.org/10.3892/ol.2014.1916
Pages: 1345-1351

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Abstract

Autophagy is a highly conserved intracellular degradation process and plays an important role in hepatocarcinogenesis. Available data show that autophagy is involved in anti‑hepatocarcinoma (HCC) therapies. Autophagy regulation involves a novel target for overcoming therapeutic resistance and sensitizing HCC to currently therapeutic methods. This is a systematic review on the interface of autophagy and the development of HCC and outlining the role of autophagy in current anti‑HCC approaches. Understanding the significance of autophagy in anti‑HCC therapy may offer a novel therapeutic target for improving anti‑cancer efficacy and prolong survival for HCC patients.

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