Volumetric modulated arc radiotherapy sparing the thyroid gland for early‑stage glottic cancer: A dosimetrical analysis

  • Authors:
    • Eun Seok Kim
    • Seung‑Gu Yeo
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  • Published online on: April 4, 2014     https://doi.org/10.3892/ol.2014.2039
  • Pages: 1987-1991
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Abstract

Previous studies on advanced radiotherapy (RT) techniques for early stage glottic cancer have focused on sparing the carotid artery. However, the aim of the present study was to evaluate the dosimetric advantages of volumetric modulated arc therapy (VMAT) in terms of sparing the thyroid gland in early‑stage glottic cancer patients. In total, 15 cT1N0M0 glottic cancer patients treated with definitive RT using VMAT were selected, and for dosimetric comparison, a conventional RT plan comprising opposed‑lateral wedged fields was generated for each patient. The carotid artery, thyroid gland and spinal cord were considered organs at risk. The prescription dose was 63 Gy at 2.25 Gy per fraction. For the thyroid gland and carotid artery, all compared parameters were significantly lower with VMAT compared with conventional RT. For the thyroid gland, the median reduction rates of the mean dose (Dmean), the volume receiving ≥30% of the prescription dose (V30) and the V50 were 32.6, 40.9 and 46.0%, respectively. The Dmean was 14.7±2.6 Gy when using VMAT compared with 22.2±3.9 Gy when using conventional RT. The differences between the techniques in terms of planning target volume coverage and dose homogeneity were not significant. When considering a recent normal tissue complication probability model, which indicated the mean thyroid gland dose as the most significant predictor of radiation‑induced hypothyroidism, the dosimetric advantage shown in this study may be valuable in reducing hypothyroidism following RT for early stage glottic cancer patients.
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June-2014
Volume 7 Issue 6

Print ISSN: 1792-1074
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Spandidos Publications style
Kim ES and Yeo SG: Volumetric modulated arc radiotherapy sparing the thyroid gland for early‑stage glottic cancer: A dosimetrical analysis. Oncol Lett 7: 1987-1991, 2014.
APA
Kim, E.S., & Yeo, S. (2014). Volumetric modulated arc radiotherapy sparing the thyroid gland for early‑stage glottic cancer: A dosimetrical analysis. Oncology Letters, 7, 1987-1991. https://doi.org/10.3892/ol.2014.2039
MLA
Kim, E. S., Yeo, S."Volumetric modulated arc radiotherapy sparing the thyroid gland for early‑stage glottic cancer: A dosimetrical analysis". Oncology Letters 7.6 (2014): 1987-1991.
Chicago
Kim, E. S., Yeo, S."Volumetric modulated arc radiotherapy sparing the thyroid gland for early‑stage glottic cancer: A dosimetrical analysis". Oncology Letters 7, no. 6 (2014): 1987-1991. https://doi.org/10.3892/ol.2014.2039