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Article

Sirt1 is a tumor promoter in lung adenocarcinoma

  • Authors:
    • Xue Chen
    • Daisuke Hokka
    • Yoshimasa Maniwa
    • Chiho Ohbayashi
    • Tomoo Itoh
    • Yoshitake Hayashi
  • View Affiliations / Copyright

    Affiliations: Division of Molecular Medicine and Medical Genetics, Department of Pathology, Kobe University Graduate School of Medicine, Kobe, Hyogo 650‑0017, Japan, Division of Thoracic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Hyogo 650‑0017, Japan, Department of Pathology, Nara Medical University, Kashihara, Nara 634‑8522, Japan, Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Hyogo 650‑0017, Japan
  • Pages: 387-393
    |
    Published online on: April 10, 2014
       https://doi.org/10.3892/ol.2014.2057
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Abstract

Sirtuin 1 (Sirt1) is a nicotinamide adenine dinucleotide‑dependent class III histone deacetylase. It reportedly can repress cellular apoptosis and senescence to affect DNA repair, stress response and aging. Notably, previous data have indicated that Sirt1 is both a tumor promoter and a tumor suppressor in tumorigenesis. However, Sirt1 expression in primary lung adenocarcinoma remains unknown. Immunohistochemical staining was performed to investigate Sirt1 expression in cancer cells in 125 consecutive resected cases of primary lung adenocarcinoma. Sirt1 expression was found to be increased in 26 (20.8%) of the 125 cases, which correlated significantly with five clinicopathological factors: Ki67 index, hypoxia‑inducible factor 1 (HIF1) molecule expression, tumor‑node‑metastasis (TNM) classification, pulmonary vein invasion and lymphatic duct invasion. In the Sirt1‑positive expression group, Sirt1 expression correlated with a higher Ki67 index and higher TNM classification, particularly for lymph node invasion and metastasis, and with a higher number of pulmonary vein invasion and lymphatic duct invasion. Additionally, a negative correlation was identified between HIF1‑positive expression and Sirt1‑negative expression. These results indicate that Sirt1 overexpression plays a promotional role in tumorigenesis and is closely associated with invasion and metastasis and, thus, it may be associated with prognosis.
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Copy and paste a formatted citation
Spandidos Publications style
Chen X, Hokka D, Maniwa Y, Ohbayashi C, Itoh T and Hayashi Y: Sirt1 is a tumor promoter in lung adenocarcinoma. Oncol Lett 8: 387-393, 2014.
APA
Chen, X., Hokka, D., Maniwa, Y., Ohbayashi, C., Itoh, T., & Hayashi, Y. (2014). Sirt1 is a tumor promoter in lung adenocarcinoma. Oncology Letters, 8, 387-393. https://doi.org/10.3892/ol.2014.2057
MLA
Chen, X., Hokka, D., Maniwa, Y., Ohbayashi, C., Itoh, T., Hayashi, Y."Sirt1 is a tumor promoter in lung adenocarcinoma". Oncology Letters 8.1 (2014): 387-393.
Chicago
Chen, X., Hokka, D., Maniwa, Y., Ohbayashi, C., Itoh, T., Hayashi, Y."Sirt1 is a tumor promoter in lung adenocarcinoma". Oncology Letters 8, no. 1 (2014): 387-393. https://doi.org/10.3892/ol.2014.2057
Copy and paste a formatted citation
x
Spandidos Publications style
Chen X, Hokka D, Maniwa Y, Ohbayashi C, Itoh T and Hayashi Y: Sirt1 is a tumor promoter in lung adenocarcinoma. Oncol Lett 8: 387-393, 2014.
APA
Chen, X., Hokka, D., Maniwa, Y., Ohbayashi, C., Itoh, T., & Hayashi, Y. (2014). Sirt1 is a tumor promoter in lung adenocarcinoma. Oncology Letters, 8, 387-393. https://doi.org/10.3892/ol.2014.2057
MLA
Chen, X., Hokka, D., Maniwa, Y., Ohbayashi, C., Itoh, T., Hayashi, Y."Sirt1 is a tumor promoter in lung adenocarcinoma". Oncology Letters 8.1 (2014): 387-393.
Chicago
Chen, X., Hokka, D., Maniwa, Y., Ohbayashi, C., Itoh, T., Hayashi, Y."Sirt1 is a tumor promoter in lung adenocarcinoma". Oncology Letters 8, no. 1 (2014): 387-393. https://doi.org/10.3892/ol.2014.2057
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