Sirt1 is a tumor promoter in lung adenocarcinoma

  • Authors:
    • Xue Chen
    • Daisuke Hokka
    • Yoshimasa Maniwa
    • Chiho Ohbayashi
    • Tomoo Itoh
    • Yoshitake Hayashi
  • View Affiliations

  • Published online on: April 10, 2014     https://doi.org/10.3892/ol.2014.2057
  • Pages: 387-393
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Abstract

Sirtuin 1 (Sirt1) is a nicotinamide adenine dinucleotide‑dependent class III histone deacetylase. It reportedly can repress cellular apoptosis and senescence to affect DNA repair, stress response and aging. Notably, previous data have indicated that Sirt1 is both a tumor promoter and a tumor suppressor in tumorigenesis. However, Sirt1 expression in primary lung adenocarcinoma remains unknown. Immunohistochemical staining was performed to investigate Sirt1 expression in cancer cells in 125 consecutive resected cases of primary lung adenocarcinoma. Sirt1 expression was found to be increased in 26 (20.8%) of the 125 cases, which correlated significantly with five clinicopathological factors: Ki67 index, hypoxia‑inducible factor 1 (HIF1) molecule expression, tumor‑node‑metastasis (TNM) classification, pulmonary vein invasion and lymphatic duct invasion. In the Sirt1‑positive expression group, Sirt1 expression correlated with a higher Ki67 index and higher TNM classification, particularly for lymph node invasion and metastasis, and with a higher number of pulmonary vein invasion and lymphatic duct invasion. Additionally, a negative correlation was identified between HIF1‑positive expression and Sirt1‑negative expression. These results indicate that Sirt1 overexpression plays a promotional role in tumorigenesis and is closely associated with invasion and metastasis and, thus, it may be associated with prognosis.
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July-2014
Volume 8 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Chen X, Hokka D, Maniwa Y, Ohbayashi C, Itoh T and Hayashi Y: Sirt1 is a tumor promoter in lung adenocarcinoma. Oncol Lett 8: 387-393, 2014
APA
Chen, X., Hokka, D., Maniwa, Y., Ohbayashi, C., Itoh, T., & Hayashi, Y. (2014). Sirt1 is a tumor promoter in lung adenocarcinoma. Oncology Letters, 8, 387-393. https://doi.org/10.3892/ol.2014.2057
MLA
Chen, X., Hokka, D., Maniwa, Y., Ohbayashi, C., Itoh, T., Hayashi, Y."Sirt1 is a tumor promoter in lung adenocarcinoma". Oncology Letters 8.1 (2014): 387-393.
Chicago
Chen, X., Hokka, D., Maniwa, Y., Ohbayashi, C., Itoh, T., Hayashi, Y."Sirt1 is a tumor promoter in lung adenocarcinoma". Oncology Letters 8, no. 1 (2014): 387-393. https://doi.org/10.3892/ol.2014.2057