STAT3, p‑STAT3 and HIF‑1α are associated with vasculogenic mimicry and impact on survival in gastric adenocarcinoma

Song,Yan‑Yan; Sun,Li‑Dan; Liu,Min‑Li; Liu,Zhong‑Liang; Chen,Fei; Zhang,Ying‑Zhe; Zheng,Yan; Zhang,Jian‑Ping

doi:10.3892/ol.2014.2059

July-2014 Volume 8 Issue 1

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July-2014 Volume 8 Issue 1

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Article

STAT3, p‑STAT3 and HIF‑1α are associated with vasculogenic mimicry and impact on survival in gastric adenocarcinoma

Authors:
- Yan‑Yan Song
- Li‑Dan Sun
- Min‑Li Liu
- Zhong‑Liang Liu
- Fei Chen
- Ying‑Zhe Zhang
- Yan Zheng
- Jian‑Ping Zhang
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Affiliations: Department of Pathology, Shandong University School of Medicine, Jinan, Shandong 250012, P.R. China, Department of Neurosurgery, Yidu Central Hospital, Weifang, Shandong 262500, P.R. China, Department of Cardiology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China, Department of Surgery, Shandong University School of Medicine, Jinan, Shandong 250012, P.R. China, Central Laboratory, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, P.R. China
Pages: 431-437
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Published online on: April 11, 2014

https://doi.org/10.3892/ol.2014.2059
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Abstract

Vasculogenic mimicry (VM) formation is important for invasion and metastasis of tumor cells in gastric adenocarcinoma (GAC). The present study aimed to investigate the association between signal transducer and activator of transcription‑3 (STAT3), phosphor‑STAT3 (p‑STAT3), hypoxia‑inducible factor‑1α (HIF‑1α) and VM formation in GAC, and discuss their clinical significance and correlation with the prognosis of patients with GAC. The expression levels of STAT3, p‑STAT3, HIF‑1α and VM were assessed in 60 cases of patients with GAC and 20 cases of patients with gastritis on tissue microarrays by immunohistochemical methods. The expression levels of STAT3, p‑STAT3, HIF‑1α and VM were higher in patients with GAC (particularly in poorly differentiated GAC) than in those with gastritis (P<0.05). The expression levels of STAT3, p‑STAT3 and HIF‑1α were higher in VM tissues compared with non‑VM tissues (P<0.05). Positive correlations existed between STAT3, p‑STAT3, HIF‑1α and VM expression (P<0.05). The expression levels of STAT3, p‑STAT3 and HIF‑1α, VM, status of lymph node metastasis and tumor differentiation degree were associated with the overall survival time of patients with GAC (P<0.05). However, only p‑STAT3 and VM expression were identified as the independent risk factors of GAC OS when analyzed with multivariate analysis. p‑STAT3 and VM play a significant role in indicating the prognosis of patients with GAC. STAT3 activation may play a positive role in VM formation of GAC by the STAT3‑p‑STAT3‑HIF‑1α‑VM effect axis.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

STAT3, p‑STAT3 and HIF‑1α are associated with vasculogenic mimicry and impact on survival in gastric adenocarcinoma

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