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Malignant phosphaturic mesenchymal tumor of the pelvis: A report of two cases

  • Authors:
    • Tokimitsu Morimoto
    • Satoshi Takenaka
    • Nobuyuki Hashimoto
    • Nobuhito Araki
    • Akira Myoui
    • Hideki Yoshikawa
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedic Surgery, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan, Department of Orthopedic Surgery, Bell Land General Hospital, Osaka 599‑8247, Japan, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka 537-8511, Japan, Medical Center for Translational Research, Osaka University Hospital, Osaka 565-0871, Japan
  • Pages: 67-71
    |
    Published online on: April 22, 2014
       https://doi.org/10.3892/ol.2014.2081
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Abstract

Tumor‑induced osteomalacia (TIO) is a rare acquired form of hypophosphatemia commonly associated with phosphaturic mesenchymal tumors (PMTs) located in the bone or soft tissue. Resection of the tumor can cure osteomalacia. Fibroblast growth factor 23 has been identified as a major pathophysiological factor responsible for phosphaturia. The majority of PMTs are benign, and malignant PMTs are uncommon. Even in rare cases, the malignant transformation of PMTs is extremely uncommon. The current study presents two cases in which the patients succumbed to malignant PMTs that developed in the pelvis. The first patient was a 35‑year‑old female with a malignant PMT occurring as a synchronous double cancer associated with papillary thyroid carcinoma. Diagnosis was difficult, as the multiple uptake on positron emission tomography with 18F‑fluorodeoxyglucose presented as pseudofractures mimicking the metastases of thyroid carcinoma. The patient succumbed to rapidly progressive lung metastases. The second patient presented with a pelvic tumor that had developed over 26 years. The patient was diagnosed with a benign PMT by open biopsy and a complete resection was performed. However, two years later, the tumor recurred and lung metastases were observed. The patient ultimately succumbed to respiratory failure due to relapsing lung metastases and disseminated intravascular coagulation. These two cases demonstrate the potential lethality of malignant PMTs and the malignant transformation of benign PMTs. Therefore, TIO patients must be followed up even if diagnosed with a benign tumor. Although TIO is an extremely rare disease, the possibility of malignant PMTs must be recognized.
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Copy and paste a formatted citation
Spandidos Publications style
Morimoto T, Takenaka S, Hashimoto N, Araki N, Myoui A and Yoshikawa H: Malignant phosphaturic mesenchymal tumor of the pelvis: A report of two cases. Oncol Lett 8: 67-71, 2014.
APA
Morimoto, T., Takenaka, S., Hashimoto, N., Araki, N., Myoui, A., & Yoshikawa, H. (2014). Malignant phosphaturic mesenchymal tumor of the pelvis: A report of two cases. Oncology Letters, 8, 67-71. https://doi.org/10.3892/ol.2014.2081
MLA
Morimoto, T., Takenaka, S., Hashimoto, N., Araki, N., Myoui, A., Yoshikawa, H."Malignant phosphaturic mesenchymal tumor of the pelvis: A report of two cases". Oncology Letters 8.1 (2014): 67-71.
Chicago
Morimoto, T., Takenaka, S., Hashimoto, N., Araki, N., Myoui, A., Yoshikawa, H."Malignant phosphaturic mesenchymal tumor of the pelvis: A report of two cases". Oncology Letters 8, no. 1 (2014): 67-71. https://doi.org/10.3892/ol.2014.2081
Copy and paste a formatted citation
x
Spandidos Publications style
Morimoto T, Takenaka S, Hashimoto N, Araki N, Myoui A and Yoshikawa H: Malignant phosphaturic mesenchymal tumor of the pelvis: A report of two cases. Oncol Lett 8: 67-71, 2014.
APA
Morimoto, T., Takenaka, S., Hashimoto, N., Araki, N., Myoui, A., & Yoshikawa, H. (2014). Malignant phosphaturic mesenchymal tumor of the pelvis: A report of two cases. Oncology Letters, 8, 67-71. https://doi.org/10.3892/ol.2014.2081
MLA
Morimoto, T., Takenaka, S., Hashimoto, N., Araki, N., Myoui, A., Yoshikawa, H."Malignant phosphaturic mesenchymal tumor of the pelvis: A report of two cases". Oncology Letters 8.1 (2014): 67-71.
Chicago
Morimoto, T., Takenaka, S., Hashimoto, N., Araki, N., Myoui, A., Yoshikawa, H."Malignant phosphaturic mesenchymal tumor of the pelvis: A report of two cases". Oncology Letters 8, no. 1 (2014): 67-71. https://doi.org/10.3892/ol.2014.2081
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