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Article

Expression of noggin, an antagonist of bone morphogenetic protein, in schwannoma: A possible mechanism

  • Authors:
    • Keiko Kaneko
    • Chikahisa Higuchi
    • Norifumi Naka
    • Hideki Yoshikawa
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka 565‑0871, Japan
  • Pages: 111-116
    |
    Published online on: May 12, 2014
       https://doi.org/10.3892/ol.2014.2138
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Abstract

Schwannoma is a benign peripheral nerve sheath tumor derived from Schwann cells. Bone scalloping, including spinal foramen enlargement, develops when the tumor is located adjacent to a bone and is a characteristic radiological feature. In the present study, to investigate the pathomechanism of bone resorption, the expression of noggin (a potent antagonist of bone morphogenetic protein) was analyzed in schwannoma tissues and compared with that observed in other soft tissue tumors. Quantitative polymerase chain reaction analysis revealed that the mRNA levels of noggin in schwannomas were significantly increased compared with the levels in other tumors. The gene product of noggin was only detected in a subset of schwannomas using immunohistochemistry and western blot analysis. Furthermore, the tissue extract from a noggin‑producing schwannoma was found to inhibit osteoblastic differentiation in MC3T3 mouse osteoblastic cells in a dose‑dependent manner. These findings indicate that bone scalloping in radiology may be induced by schwannoma‑secreted noggin. In addition, noggin may have potential as a novel molecular and diagnostic marker for identifying certain types of schwannoma.
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Copy and paste a formatted citation
Spandidos Publications style
Kaneko K, Higuchi C, Naka N and Yoshikawa H: Expression of noggin, an antagonist of bone morphogenetic protein, in schwannoma: A possible mechanism. Oncol Lett 8: 111-116, 2014.
APA
Kaneko, K., Higuchi, C., Naka, N., & Yoshikawa, H. (2014). Expression of noggin, an antagonist of bone morphogenetic protein, in schwannoma: A possible mechanism. Oncology Letters, 8, 111-116. https://doi.org/10.3892/ol.2014.2138
MLA
Kaneko, K., Higuchi, C., Naka, N., Yoshikawa, H."Expression of noggin, an antagonist of bone morphogenetic protein, in schwannoma: A possible mechanism". Oncology Letters 8.1 (2014): 111-116.
Chicago
Kaneko, K., Higuchi, C., Naka, N., Yoshikawa, H."Expression of noggin, an antagonist of bone morphogenetic protein, in schwannoma: A possible mechanism". Oncology Letters 8, no. 1 (2014): 111-116. https://doi.org/10.3892/ol.2014.2138
Copy and paste a formatted citation
x
Spandidos Publications style
Kaneko K, Higuchi C, Naka N and Yoshikawa H: Expression of noggin, an antagonist of bone morphogenetic protein, in schwannoma: A possible mechanism. Oncol Lett 8: 111-116, 2014.
APA
Kaneko, K., Higuchi, C., Naka, N., & Yoshikawa, H. (2014). Expression of noggin, an antagonist of bone morphogenetic protein, in schwannoma: A possible mechanism. Oncology Letters, 8, 111-116. https://doi.org/10.3892/ol.2014.2138
MLA
Kaneko, K., Higuchi, C., Naka, N., Yoshikawa, H."Expression of noggin, an antagonist of bone morphogenetic protein, in schwannoma: A possible mechanism". Oncology Letters 8.1 (2014): 111-116.
Chicago
Kaneko, K., Higuchi, C., Naka, N., Yoshikawa, H."Expression of noggin, an antagonist of bone morphogenetic protein, in schwannoma: A possible mechanism". Oncology Letters 8, no. 1 (2014): 111-116. https://doi.org/10.3892/ol.2014.2138
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