Primary hepatic malignant fibrous histiocytoma mimicking hepatocellular carcinoma: A report of two cases
- Authors:
- Jinghui Dong
- Weimin An
- Wei Ma
- Xiaodong Guo
- Yuanzhi Gao
- Changchun Liu
- Yongwu Li
View Affiliations
Affiliations: Medical Imaging Center, The 302nd Hospital, Beijing 100039, P.R. China, Department of Pathology, The 302nd Hospital, Beijing 100039, P.R. China
- Published online on: August 27, 2014 https://doi.org/10.3892/ol.2014.2483
-
Pages:
2150-2154
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Abstract
Malignant fibrous histiocytoma (MFH) is a tumor that occurs throughout the body as a relatively uncommon entity. The current study presents two cases of primary malignant fibrous histiocytoma of the liver. The first case was of a 67‑year‑old male who exhibited no symptoms or abnormal physical signs, and in whom the lesion was found by ultrasound examination during a routine physical examination. The second case was of a 35‑year‑old male who presented with persistent malaise, weight loss and intermittent right upper quadrant pain. The presence of liver cirrhosis due to hepatitis B virus, which was identified 10 years previously, and the clinical appearance caused MFH to appear as hepatocellular carcinoma at the time of the initial diagnosis. Abdominal magnetic resonance imaging scans were the main tools of diagnosis, but the MFH mimicked hepatocellular carcinoma due to the similar morphological characteristics, the rare occurrence of MFH and the underlying diseases of the liver. The first patient underwent a complete resection and recovered well, while the second patient underwent palliative treatment due to the large size of the tumor and the obstructive emboli in the portal vein. The diagnoses of the tumors were confirmed as MFH by histopathology and immunohistochemistry.
View References
1
|
Weiss SW and Enzinger FM: Malignant
fibrous histiocytoma: an analysis of 200 cases. Cancer.
41:2250–2266. 1978.
|
2
|
Liver Cancer Study Group of Japan. Primary
liver cancer in Japan. Clinicopathologic features and results of
surgical treatment. Ann Surg. 211:277–287. 1990.
|
3
|
Kearney MM, Soule EH and Ivins JC:
Malignant fibrous histiocytoma: a retrospective study of 167 cases.
Cancer. 45:167–178. 1980.
|
4
|
Yu JS, Kim KW, Kim CS, et al: Primary
malignant fibrous histiocytoma of the liver: imaging features of
five surgically confirmed cases. Abdom Imaging. 24:386–391.
1999.
|
5
|
Li YR, Akbari E, Tretiakova MS, et al:
Primary hepatic malignant fibrous histiocytoma: clinicopathologic
characteristics and prognostic value of ezrin expression. Am J Surg
Pathol. 32:1144–1158. 2008.
|
6
|
Lee YT: Leiomyosarcoma of the
gastro-intestinal tract: general pattern of metastasis and
recurrence. Cancer Treat Rev. 10:91–101. 1983.
|
7
|
Wunderbaldinger P, Schima W, Harisinghani
M and Saini S: Primary malignant fibrous histiocytoma of the liver:
CT and MR findings. AJR Am J Roentgenol. 171:900–901. 1998.
|
8
|
Hwang HS, Ha ND, Jeong YK, et al:
Simultaneous occurrence of malignant fibrous histiocytoma and
hepatocellular carcinoma in cirrhotic liver: A case report. World J
Hepatol. 27:256–261. 2011.
|
9
|
Atmatzidis KS, Pavlidis TE, Galanis IN, et
al: Malignant fibrous histiocytoma of the abdominal cavity: report
of a case. Surg Today. 33:794–796. 2003.
|
10
|
Rydholm A and Syk I: Malignant fibrous
histiocytoma of soft tissue. Correlation between clinical variables
and histologic malignancy grade. Cancer. 57:2323–2324. 1986.
|
11
|
Ding GH, Wu MC, Yang JH, et al: Primary
hepatic malignant fibrous histiocytoma mimicking
cystadenocarcinoma: a case report. Hepatobiliary Pancreat Dis Int.
5:620–623. 2006.
|