Expression of metastasis suppressor 1 in cervical carcinoma and the clinical significance

  • Authors:
    • Juan Zhang
    • Ying Tong
    • Li Ren
    • Chun-Dong Li
  • View Affiliations

  • Published online on: September 8, 2014     https://doi.org/10.3892/ol.2014.2508
  • Pages: 2145-2149
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

This study aimed to investigate the expression of metastasis suppressor 1 (MTSS1) in cervical intraepithelial neoplasia (CIN) and malignant cervical tissues, and the role of MTSS1 in carcinogenesis. MTSS1 expression was detected by immunohistochemistry in 147 cervical tissue specimens collected from 30 healthy individuals, 30 patients with cervical CIN I, 30 patients with CIN II‑III and 57 patients with cervical cancer. The association between MTSS1 expression and clinicopathological factors was also examined. MTSS1 was found to be positively expressed in 43.33% CIN I cervical tissues, 100% CIN II‑III cervical tissues and 100% malignant cervical tissues, but was weakly or negatively expressed in benign cervical tissues. The positive expression rates of MTSS1 were significantly higher in CIN II‑III and malignant cervical tissues than in CIN I or normal cervical tissues (P<0.05). When examining MTSS1 expression and clinicopathological factors, the strong positive MTSS1 expression rates in early‑stage versus middle‑ and advanced‑stage cervical cancer tissues were 39.13% and 82.35%, respectively. Furthermore, the positive expression rates of MTSS1 were significantly higher in cervical tissues at an advanced clinical stage than those at an early clinical stage (P<0.05). The results suggest that the dysregulation of MTSS1 may be involved in cervical carcinogenesis, and thus MTSS1 may be a novel diagnostic biomarker or therapeutic target in cervical cancer patients.
View Figures
View References

Related Articles

Journal Cover

November-2014
Volume 8 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zhang J, Tong Y, Ren L and Li C: Expression of metastasis suppressor 1 in cervical carcinoma and the clinical significance. Oncol Lett 8: 2145-2149, 2014
APA
Zhang, J., Tong, Y., Ren, L., & Li, C. (2014). Expression of metastasis suppressor 1 in cervical carcinoma and the clinical significance. Oncology Letters, 8, 2145-2149. https://doi.org/10.3892/ol.2014.2508
MLA
Zhang, J., Tong, Y., Ren, L., Li, C."Expression of metastasis suppressor 1 in cervical carcinoma and the clinical significance". Oncology Letters 8.5 (2014): 2145-2149.
Chicago
Zhang, J., Tong, Y., Ren, L., Li, C."Expression of metastasis suppressor 1 in cervical carcinoma and the clinical significance". Oncology Letters 8, no. 5 (2014): 2145-2149. https://doi.org/10.3892/ol.2014.2508