Extranodal natural killer/T‑cell lymphoma, nasal type, involving the skin, misdiagnosed as nasosinusitis and a fungal infection: A case report and literature review

Zheng,Yan; Jia,Jinjing; Li,Wensheng; Wang,Juan; Tian,Qiong; Li,Zhengxiao; Yang,Jing; Dong,Xinyu; Pan,Ping; Xiao,Shengxiang

doi:10.3892/ol.2014.2509

Extranodal natural killer/T‑cell lymphoma, nasal type, involving the skin, misdiagnosed as nasosinusitis and a fungal infection: A case report and literature review

Authors:
- Yan Zheng
- Jinjing Jia
- Wensheng Li
- Juan Wang
- Qiong Tian
- Zhengxiao Li
- Jing Yang
- Xinyu Dong
- Ping Pan
- Shengxiang Xiao
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Affiliations: Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China, Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China, Department of Pathology, The Third Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710068, P.R. China, Department of Dermatology, Chang'an Hospital, Xi'an, Shaanxi 710016, P.R. China
Published online on: September 8, 2014 https://doi.org/10.3892/ol.2014.2509
Pages: 2253-2262

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Abstract

The present study reports a case of extranodal natural killer (NK)/T‑cell lymphoma, nasal type, involving the skin. The clinical manifestations, pathological characteristics, treatment and prognosis of the case were analyzed to improve the clinical diagnosis and treatment for this disease. The patient was a 56‑year‑old male, presenting with dark red nodules and plaques that had been visible on the nose for half a year. Based on the skin lesions and histopathological and immunohistochemical examination results, the patient was diagnosed with extranodal NK/T‑cell lymphoma, nasal type. This disease has unique histopathological and immunohistochemical features and a high malignancy. The condition tends to be misdiagnosed and has a poor prognosis, but seldom involves the skin. In the present case, only radiotherapy was performed, with no relapse occurring within 6 months.

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