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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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May-2015 Volume 9 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Vav3 oncogene is upregulated and a poor prognostic factor in breast cancer patients

  • Authors:
    • Xin Chen
    • Si Chen
    • Xiao‑An Liu
    • Wen‑Bin Zhou
    • Rui‑Rui Ma
    • Lin Chen
  • View Affiliations / Copyright

    Affiliations: Department of Breast Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Department of General Surgery, Songjiang Central Hospital, Shanghai 201699, P.R. China
  • Pages: 2143-2148
    |
    Published online on: March 2, 2015
       https://doi.org/10.3892/ol.2015.3004
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Abstract

The Vav3 oncogene is overexpressed and has a significant role in the tumorigenesis of prostate cancer and glioblastoma. In the present study, the expression status and prognostic value of Vav3 expression was investigated in breast cancer. Vav3 protein levels were analyzed by immunoblotting in human breast cancer and epithelial cell lines. Immunohistochemistry was used to detect Vav3 in a tissue microarray of 173 breast cancers and 19 benign breast lesions. Statistical analysis was performed to reveal the association between Vav3 expression and clinicopathological parameters. Disease‑free survival (DFS) and overall survival (OS) were calculated by Kaplan‑Meier analysis and the Cox regression model. The Vav3 protein level was higher in the breast cancer cell lines than in the normal human breast cells. Vav3 was expressed in 86.1% of breast cancer patients, but in only 15.6% patients with benign breast disease. Patients with negative estrogen receptor expression, axillary lymph node involvement and a high tumor-node-metastasis stage demonstrated a higher positive rate of Vav3 expression. The Kaplan‑Meier survival analysis revealed that patients with higher Vav3 expression exhibited shorter DFS and OS times. The multivariate Cox analysis revealed that Vav3 was a prognostic factor of survival. Overall, Vav3 was overexpressed in human breast cancer cells and this correlated with a shorter survival time, indicating that Vav3 is a biomarker of a poor prognosis for breast cancer patients.
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Copy and paste a formatted citation
Spandidos Publications style
Chen X, Chen S, Liu XA, Zhou WB, Ma RR and Chen L: Vav3 oncogene is upregulated and a poor prognostic factor in breast cancer patients. Oncol Lett 9: 2143-2148, 2015.
APA
Chen, X., Chen, S., Liu, X., Zhou, W., Ma, R., & Chen, L. (2015). Vav3 oncogene is upregulated and a poor prognostic factor in breast cancer patients. Oncology Letters, 9, 2143-2148. https://doi.org/10.3892/ol.2015.3004
MLA
Chen, X., Chen, S., Liu, X., Zhou, W., Ma, R., Chen, L."Vav3 oncogene is upregulated and a poor prognostic factor in breast cancer patients". Oncology Letters 9.5 (2015): 2143-2148.
Chicago
Chen, X., Chen, S., Liu, X., Zhou, W., Ma, R., Chen, L."Vav3 oncogene is upregulated and a poor prognostic factor in breast cancer patients". Oncology Letters 9, no. 5 (2015): 2143-2148. https://doi.org/10.3892/ol.2015.3004
Copy and paste a formatted citation
x
Spandidos Publications style
Chen X, Chen S, Liu XA, Zhou WB, Ma RR and Chen L: Vav3 oncogene is upregulated and a poor prognostic factor in breast cancer patients. Oncol Lett 9: 2143-2148, 2015.
APA
Chen, X., Chen, S., Liu, X., Zhou, W., Ma, R., & Chen, L. (2015). Vav3 oncogene is upregulated and a poor prognostic factor in breast cancer patients. Oncology Letters, 9, 2143-2148. https://doi.org/10.3892/ol.2015.3004
MLA
Chen, X., Chen, S., Liu, X., Zhou, W., Ma, R., Chen, L."Vav3 oncogene is upregulated and a poor prognostic factor in breast cancer patients". Oncology Letters 9.5 (2015): 2143-2148.
Chicago
Chen, X., Chen, S., Liu, X., Zhou, W., Ma, R., Chen, L."Vav3 oncogene is upregulated and a poor prognostic factor in breast cancer patients". Oncology Letters 9, no. 5 (2015): 2143-2148. https://doi.org/10.3892/ol.2015.3004
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