Open Access

Expression of CC chemokine receptor 5 in clear cell renal cell carcinoma and its clinical significance

  • Authors:
    • Koo Han Yoo
    • Dong‑Gi Lee
    • Kyu Yeoun Won
    • Sung‑Jig  Lim
    • Yong‑Koo Park
    • Sung‑Goo Chang
  • View Affiliations

  • Published online on: March 17, 2015     https://doi.org/10.3892/ol.2015.3048
  • Pages: 2085-2089
  • Copyright: © Yoo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

DNA hypomethylation was the initial epigenetic abnormality recognized in human malignancy. In the present study, the GoldenGate high‑throughput genotyping assay was adapted to determine the methylation state of 1,505 specific CpG sites in 807 cancer‑related genes. The methylation results revealed that CC chemokine receptor 5 (CCR5) was hypomethylated (mean β‑value difference, ‑0.21) in clear cell renal cell carcinoma (CCRCC) tissue. Tissue samples from 61 CCRCC cases were used for immunohistochemical staining, and patients with low CCR5 expression (n=44) were compared with those with high CCR5 expression (n=17). Tumor (T) stage was significantly lower in the low expression group compared with the high expression group (P=0.047). The Fuhrman grade of patients in the low expression group was significantly lower than that of patients in the high expression group (P=0.044). Whilst the node (N) and metastasis (M) stages of the CCR5 low expression group appeared to be lower compared with those of the CCR5 high expression group; this difference was not statistically significant (N stage, P=0.632; M stage, P=0.896). Additionally, patients in the low expression group had lower risks of postoperative tumor recurrence (P=0.110) and mortality from CCRCC (P=0.159) compared with those in the high expression group, however, this was also without statistical significance. The results indicate that CCR5 hypomethylation is associated with cancer tissue to a greater extent than normal tissue. Although the biological function of CCR5 in CCRCC remains to be established, low CCR5 expression is associated with low T stage and low Fuhrman grade in these patients.
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May-2015
Volume 9 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Yoo KH, Lee DG, Won KY, Lim SJ, Park YK and Chang SG: Expression of CC chemokine receptor 5 in clear cell renal cell carcinoma and its clinical significance. Oncol Lett 9: 2085-2089, 2015
APA
Yoo, K.H., Lee, D., Won, K.Y., Lim, S., Park, Y., & Chang, S. (2015). Expression of CC chemokine receptor 5 in clear cell renal cell carcinoma and its clinical significance. Oncology Letters, 9, 2085-2089. https://doi.org/10.3892/ol.2015.3048
MLA
Yoo, K. H., Lee, D., Won, K. Y., Lim, S., Park, Y., Chang, S."Expression of CC chemokine receptor 5 in clear cell renal cell carcinoma and its clinical significance". Oncology Letters 9.5 (2015): 2085-2089.
Chicago
Yoo, K. H., Lee, D., Won, K. Y., Lim, S., Park, Y., Chang, S."Expression of CC chemokine receptor 5 in clear cell renal cell carcinoma and its clinical significance". Oncology Letters 9, no. 5 (2015): 2085-2089. https://doi.org/10.3892/ol.2015.3048