Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
May-2015 Volume 9 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2015 Volume 9 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Endostatin improves cancer-associated systemic syndrome in a lung cancer model

  • Authors:
    • Xia Wang
    • Rui‑Yu Zhan
    • Yu‑Yi Wang
    • Xi Yan
    • Dan Cao
    • Yan Li
    • Yi‑Qin Wang
    • Feng Luo
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2023-2030
    |
    Published online on: March 17, 2015
       https://doi.org/10.3892/ol.2015.3049
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Cancer-associated systemic syndrome (CASS) is characterized by a constellation of symptoms, including progressive weight loss, anemia, endocrine disorders, gastrointestinal dysfunction, muscle and adipose atrophy, hepatic peliosis and kidney failure. The present study assesses the effects of endostatin on CASS and any possible underlying mechanism in tumor‑bearing mice. The results showed that the inoculation of Lewis lung carcinoma cells into mice led to CASS that was characterized by a notable decrease in body weight, severe anemia phenotype, disordered biochemistry, hepatosplenomegaly, and a marked increase in serum vascular endothelial growth factor (VEGF), tumor necrosis factor α and interleukin‑6 (IL‑6). The continuous injection of 10 mg/kg/day endostatin suppressed tumor growth and alleviated CASS in the tumor‑bearing mice, as shown by weight gain, improvement in biochemistry and anemia, and the preservation of organ function. The effects of endostatin on CASS in the tumor‑bearing mice were accompanied by the downregulation of serum VEGF and IL‑6. Collectively, these findings indicate that endostatin improves CASS in tumor‑bearing mice by decreasing the serum levels of VEGF and IL-6.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Nathanson L and Hall TC: Introduction: paraneoplastic syndromes. Semin Oncol. 24:265–268. 1997.PubMed/NCBI

2 

Nakamura I, Shibata M, Gonda K, et al: Serum levels of vascular endothelial growth factor are increased and correlate with malnutrition, immunosuppression involving MDSCs and systemic inflammation in patients with cancer of the digestive system. Oncol Lett. 5:1682–1686. 2013.PubMed/NCBI

3 

Tisdale MJ: Cachexia in cancer patients. Nat Rev Cancer. 2:862–871. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Inui A: Cancer anorexia-cachexia syndrome: current issues in research and management. CA Cancer J Clin. 52:72–91. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Takahashi Y, Yasumoto K and Mai M: Chemotherapy under cachectic conditions and the possibility of cachexia-controlled chemotherapy. Oncol Rep. 14:135–140. 2005.PubMed/NCBI

6 

Krzystek-Korpacka M, Matusiewicz M, Diakowska D, et al: Impact of weight loss on circulating IL-1, IL-6, IL-8, TNF-alpha, VEGF-A, VEGF-C and midkine in gastroesophageal cancer patients. Clin Biochem. 40:1353–1360. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Ebos JM, Lee CR, Christensen JG, et al: Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy. Proc Natl Acad Sci USA. 104:17069–17074. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Xue Y, Religa P, Cao R, et al: Anti-VEGF agents confer survival advantages to tumor-bearing mice by improving cancer-associated systemic syndrome. Proc Natl Acad Sci USA. 105:18513–18518. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Cao Y: Off-tumor target - beneficial site for antiangiogenic cancer therapy? Nat Rev Clin Oncol. 7:604–608. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Ling Y, Yang Y, Lu N, et al: Endostar, a novel recombinant human endostatin, exerts antiangiogenic effect via blocking VEGF-induced tyrosine phosphorylation of KDR/Flk-1 of endothelial cells. Biochem Biophys Res Commun. 361:79–84. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Zhang Y, Zhang J, Jiang D, et al: Inhibition of T-type Ca2+ channels by endostatin attenuates human glioblastoma cell proliferation and migration. Br J Pharmacol. 166:1247–1260. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Lim J, Duong T, Lee G, et al: The effect of intracellular protein delivery on the anti-tumor activity of recombinant human endostatin. Biomaterials. 34:6261–6271. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Xu W, Ye P, Li Z, et al: Endostar, a recently introduced recombinant human endostatin, inhibits proliferation and migration through regulating growth factors, adhesion factors and inflammatory mediators in choroid-retinal endothelial cells. Mol Biol (Mosk). 44:664–670. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Huszthy PC, Brekken C, Pedersen TB, et al: Antitumor efficacy improved by local delivery of species-specific endostatin. J Neurosurg. 104:118–128. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Zhang X, Yang G, Zhang Y, et al: An experimental research into endostatin microbubble combined with focused ultrasound for anti-tumor angiogenesis in colon cancer. Gastroenterol Rep (Oxf). 2:44–53. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Ning T, Jiang M, Peng Q, et al: Low-dose endostatin normalizes the structure and function of tumor vasculature and improves the delivery and anti-tumor efficacy of cytotoxic drugs in a lung cancer xenograft murine model. Thoracic Cancer. 3:229–238. 2012. View Article : Google Scholar

17 

Jain RK: Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science. 307:58–62. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Kayacan O, Karnak D, Beder S, et al: Impact of TNF-alpha and IL-6 levels on development of cachexia in newly diagnosed NSCLC patients. Am J Clin Oncol. 29:328–335. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Yang Q, Wan L, Zhou Z, et al: Parthenolide from Parthenium integrifolium reduces tumor burden and alleviate cachexia symptoms in the murine CT-26 model of colorectal carcinoma. Phytomedicine. 20:992–998. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Noguchi Y, Makino T, Yoshikawa T, et al: The possible role of TNF-alpha and IL-2 in inducing tumor-associated metabolic alterations. Surg Today. 26:36–41. 1996. View Article : Google Scholar : PubMed/NCBI

21 

Barton BE and Murphy TF: Cancer cachexia is mediated in part by the induction of IL-6-like cytokines from the spleen. Cytokine. 16:251–257. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Liu S, Wu HJ, Zhang ZQ, et al: L-carnitine ameliorates cancer cachexia in mice by regulating the expression and activity of carnitine palmityl transferase. Cancer Biol Ther. 12:125–130. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Kamba T, Tam BY, Hashizume H, et al: VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature. Am J Physiol Heart Circ Physiol. 290:H560–H576. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Rein DT, Volkmer AK, Volkmer J, et al: Systemic administration of bevacizumab prolongs survival in an in vivo model of platinum pre-treated ovarian cancer. Oncol Lett. 3:530–534. 2012.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang X, Zhan RY, Wang YY, Yan X, Cao D, Li Y, Wang YQ and Luo F: Endostatin improves cancer-associated systemic syndrome in a lung cancer model. Oncol Lett 9: 2023-2030, 2015.
APA
Wang, X., Zhan, R., Wang, Y., Yan, X., Cao, D., Li, Y. ... Luo, F. (2015). Endostatin improves cancer-associated systemic syndrome in a lung cancer model. Oncology Letters, 9, 2023-2030. https://doi.org/10.3892/ol.2015.3049
MLA
Wang, X., Zhan, R., Wang, Y., Yan, X., Cao, D., Li, Y., Wang, Y., Luo, F."Endostatin improves cancer-associated systemic syndrome in a lung cancer model". Oncology Letters 9.5 (2015): 2023-2030.
Chicago
Wang, X., Zhan, R., Wang, Y., Yan, X., Cao, D., Li, Y., Wang, Y., Luo, F."Endostatin improves cancer-associated systemic syndrome in a lung cancer model". Oncology Letters 9, no. 5 (2015): 2023-2030. https://doi.org/10.3892/ol.2015.3049
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Zhan RY, Wang YY, Yan X, Cao D, Li Y, Wang YQ and Luo F: Endostatin improves cancer-associated systemic syndrome in a lung cancer model. Oncol Lett 9: 2023-2030, 2015.
APA
Wang, X., Zhan, R., Wang, Y., Yan, X., Cao, D., Li, Y. ... Luo, F. (2015). Endostatin improves cancer-associated systemic syndrome in a lung cancer model. Oncology Letters, 9, 2023-2030. https://doi.org/10.3892/ol.2015.3049
MLA
Wang, X., Zhan, R., Wang, Y., Yan, X., Cao, D., Li, Y., Wang, Y., Luo, F."Endostatin improves cancer-associated systemic syndrome in a lung cancer model". Oncology Letters 9.5 (2015): 2023-2030.
Chicago
Wang, X., Zhan, R., Wang, Y., Yan, X., Cao, D., Li, Y., Wang, Y., Luo, F."Endostatin improves cancer-associated systemic syndrome in a lung cancer model". Oncology Letters 9, no. 5 (2015): 2023-2030. https://doi.org/10.3892/ol.2015.3049
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team