Open Access

Acute myeloid leukemia with monosomy 7, ectopic virus integration site-1 overexpression and central diabetes insipidus: A case report

  • Authors:
    • Hongbing Ma
    • Jing Yang
    • Bing Xiang
    • Yongqian Jia
  • View Affiliations

  • Published online on: April 23, 2015     https://doi.org/10.3892/ol.2015.3139
  • Pages: 2459-2462
  • Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Central diabetes insipidus (DI) is a rare complication in patients with acute myeloid leukemia (AML), typically occurring in patients with abnormalities of chromosomes 3 or 7. The association between AML with monosomy 7 and DI has been described in a number of studies; however, DI has been rarely reported in cases of ectopic virus integration site‑1 (EVI1)‑positive AML with monosomy 7. The current study reports a case of AML with monosomy 7 and EVI1 overexpression, with central DI as the initial symptom. The patient was an 18‑year‑old female who presented with polyuria and polydipsia. Bone marrow aspiration revealed 83.5% myeloperoxidase‑positive blasts without trilineage myelodysplasia. The karyotype was 45,XX,‑7, and the patient presented monosomy 7 and EVI1 overexpression (‑7/EVI1+) without 3q aberration. Treatment with induction therapy was unsuccessful. To the best of our knowledge, this is the second case of DI‑AML with ‑7/EVI1+ and without a 3q aberration. The possible mechanisms associated with EVI1, monosomy 7 and DI were investigated.
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June-2015
Volume 9 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Ma H, Yang J, Xiang B and Jia Y: Acute myeloid leukemia with monosomy 7, ectopic virus integration site-1 overexpression and central diabetes insipidus: A case report. Oncol Lett 9: 2459-2462, 2015.
APA
Ma, H., Yang, J., Xiang, B., & Jia, Y. (2015). Acute myeloid leukemia with monosomy 7, ectopic virus integration site-1 overexpression and central diabetes insipidus: A case report. Oncology Letters, 9, 2459-2462. https://doi.org/10.3892/ol.2015.3139
MLA
Ma, H., Yang, J., Xiang, B., Jia, Y."Acute myeloid leukemia with monosomy 7, ectopic virus integration site-1 overexpression and central diabetes insipidus: A case report". Oncology Letters 9.6 (2015): 2459-2462.
Chicago
Ma, H., Yang, J., Xiang, B., Jia, Y."Acute myeloid leukemia with monosomy 7, ectopic virus integration site-1 overexpression and central diabetes insipidus: A case report". Oncology Letters 9, no. 6 (2015): 2459-2462. https://doi.org/10.3892/ol.2015.3139