Primary carcinoid tumor of the kidney with estrogen and progesterone receptor expression. A case report

Lin,Chunhua; Wu,Jitao; Gao,Zhenli; Qu,Guimei; Wang,Wei; Yu,Guohua

doi:10.3892/ol.2015.3167

Primary carcinoid tumor of the kidney with estrogen and progesterone receptor expression. A case report

Authors:
- Chunhua Lin
- Jitao Wu
- Zhenli Gao
- Guimei Qu
- Wei Wang
- Guohua Yu
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Affiliations: Department of Surgery, Shandong University School of Medicine, Jinan, Shandong 250012, P.R. China, Department of Urological Surgery, Affiliated Yantai Yuhuangding Hospital, Medical College of Qingdao University, Yantai, Shandong 264000, P.R. China, Department of Pathology, Affiliated Yantai Yuhuangding Hospital, Medical College of Qingdao University, Yantai, Shandong 264000, P.R. China
Published online on: April 30, 2015 https://doi.org/10.3892/ol.2015.3167
Pages: 449-452

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Abstract

Primary carcinoid tumors are uncommon neoplasms in the kidney. The current study presents a case of primary carcinoid tumor of the kidney in a 49-year‑old female who suffered from painless gross hematuria for half a month. Left hydronephrosis, a horseshoe kidney and a space‑occupying lesion of the left ureter were found by abdominal computed tomography scans and ultrasonic testing. Surgery was performed and an oval tumor was found under the left ureter; the tumor and left kidney were excised completely. The neoplasm was composed of solid nests of cells, trabeculae, adenoid structures and anastomosing cords in a loose and myxoid background. The tumor cells, which were consistent in volume, exhibited centrally oval nuclei with inconspicuous nucleoli, and eosinophilic finely granular cytoplasm. Upon immunohistochemical staining, the neoplastic cells were positive for AE1/AE3, vimentin, synaptophysin, chromogranin A, estrogen receptor and progesterone receptor, while being negative for epithelial membrane antigen, inhibin A, cluster of differentiation (CD)99, S‑100 and CD10. Based on the histological characteristics, a diagnosis of primary carcinoid tumor of the left kidney was formed. The patient did not receive further treatment. The total follow‑up period was 18 months after the surgery and repeated imaging examinations every 6 months revealed no recurrence.

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