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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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July-2015 Volume 10 Issue 1

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Case Report

Transient partial response of poorly-differentiated thyroid carcinoma to sunitinib treatment: A case report

  • Authors:
    • Li Jin Duo
    • Jiang Rong
    • Wang Bin
    • Ma Chun Hua
    • Sun Li Wei
    • Lv Yuan
  • View Affiliations / Copyright

    Affiliations: Department of Tumor Intervention, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin 300060, P.R. China
  • Pages: 492-496
    |
    Published online on: May 4, 2015
       https://doi.org/10.3892/ol.2015.3174
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Abstract

Thyroid cancer is the most common endocrine malignancy, with an increasing prevalence worldwide. Poorly‑differentiated thyroid cancer (PDTC) is relatively rare and its prognosis is poor. To date, no ideal treatment strategy is available for patients with advanced recurrent PDTC, particularly for patients in crisis. However, partial success in treating thyroid cancer has been achieved with targeted therapy, and advances made in understanding the molecular biology of the tumor. The current study describes the case of a patient diagnosed with PDTC following presentation with hoarseness, orthopnea, and a large right neck mass. A transient partial response to sunitinib malate treatment was achieved for >3 months. In addition, the current study reviewed the relevant literature and discussed the therapeutic value of sunitinib as a more favorable treatment strategy for patients with advanced recurrent PDTC compared with the currently available treatments. Successful treatment with sunitinib, as well as molecular analysis of the tumor, occurred in the present case. Sunitinib was determined to have potential in treating thyroid tumors, however, larger prospective studies are required to validate the findings of the current case study prior to the application of this agent in clinical practice.
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Copy and paste a formatted citation
Spandidos Publications style
Duo LJ, Rong J, Bin W, Hua MC, Wei SL and Yuan L: Transient partial response of poorly-differentiated thyroid carcinoma to sunitinib treatment: A case report. Oncol Lett 10: 492-496, 2015.
APA
Duo, L.J., Rong, J., Bin, W., Hua, M.C., Wei, S.L., & Yuan, L. (2015). Transient partial response of poorly-differentiated thyroid carcinoma to sunitinib treatment: A case report. Oncology Letters, 10, 492-496. https://doi.org/10.3892/ol.2015.3174
MLA
Duo, L. J., Rong, J., Bin, W., Hua, M. C., Wei, S. L., Yuan, L."Transient partial response of poorly-differentiated thyroid carcinoma to sunitinib treatment: A case report". Oncology Letters 10.1 (2015): 492-496.
Chicago
Duo, L. J., Rong, J., Bin, W., Hua, M. C., Wei, S. L., Yuan, L."Transient partial response of poorly-differentiated thyroid carcinoma to sunitinib treatment: A case report". Oncology Letters 10, no. 1 (2015): 492-496. https://doi.org/10.3892/ol.2015.3174
Copy and paste a formatted citation
x
Spandidos Publications style
Duo LJ, Rong J, Bin W, Hua MC, Wei SL and Yuan L: Transient partial response of poorly-differentiated thyroid carcinoma to sunitinib treatment: A case report. Oncol Lett 10: 492-496, 2015.
APA
Duo, L.J., Rong, J., Bin, W., Hua, M.C., Wei, S.L., & Yuan, L. (2015). Transient partial response of poorly-differentiated thyroid carcinoma to sunitinib treatment: A case report. Oncology Letters, 10, 492-496. https://doi.org/10.3892/ol.2015.3174
MLA
Duo, L. J., Rong, J., Bin, W., Hua, M. C., Wei, S. L., Yuan, L."Transient partial response of poorly-differentiated thyroid carcinoma to sunitinib treatment: A case report". Oncology Letters 10.1 (2015): 492-496.
Chicago
Duo, L. J., Rong, J., Bin, W., Hua, M. C., Wei, S. L., Yuan, L."Transient partial response of poorly-differentiated thyroid carcinoma to sunitinib treatment: A case report". Oncology Letters 10, no. 1 (2015): 492-496. https://doi.org/10.3892/ol.2015.3174
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