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Mature brain-derived neurotrophic factor and its receptor TrkB are upregulated in human glioma tissues

  • Authors:
    • Jing Xiong
    • Li Zhou
    • Yoon Lim
    • Miao Yang
    • Yu‑Hong Zhu
    • Zhi‑Wei Li
    • Deng‑Li Fu
    • Xin‑Fu Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101, P.R. China, The First People's Hospital of Yunnan, Kunming, Yunnan 650000, P.R. China, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA 5000, Australia
    Copyright: © Xiong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 223-227
    |
    Published online on: May 6, 2015
       https://doi.org/10.3892/ol.2015.3181
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Abstract

There are two forms of brain-derived neurotrophic factor (BDNF), precursor of BDNF (proBDNF) and mature BDNF, which each exert opposing effects through two different transmembrane receptor signaling systems, consisting of p75 neurotrophin receptor (p75NTR) and tyrosine receptor kinase B (TrkB). Previous studies have demonstrated that proBDNF promotes cell death and inhibits the growth and migration of C6 glioma cells through p75NTR in vitro, while mature BDNF has opposite effects on C6 glioma cells. It is hypothesized that mature BDNF is essential in the development of malignancy in gliomas. However, histological data obtained in previous studies were unable distinguish mature BDNF from proBDNF due to the lack of specific antibodies. The present study investigated the expression of mature BDNF using a specific sheep monoclonal anti‑mature BDNF antibody in 42 human glioma tissues of different grades and 10 control tissues. The correlation between mature BDNF and TrkB was analyzed. Mature BDNF expression was significantly increased in high‑grade gliomas, and was positively correlated with the malignancy of the tumor and TrkB receptor expression. The present data have demonstrated that increased levels of mature BDNF contribute markedly to the development of malignancy of human gliomas through the primary BDNF receptor TrkB.
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1 

Nakagawara A, Azar CG, Scavarda NJ and Brodeur GM: Expression and function of TRk-B and BDNF in human neuroblastomas. Mol Cell Biol. 14:759–767. 1994.PubMed/NCBI

2 

Stephan H, Zakrzewski JL, Bölöni R, Grasemann C, Lohmann DR and Eggert A: Neurotrophin receptor expression in human primary retinoblastomas and retinoblastoma cell lines. Pediatr Blood Cancer. 50:218–222. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Artico M, Bronzetti E, Pompili E, Ionta B, Alicino V, D'Ambrosio A, Santoro A, Pastore FS, Elenkov I and Fumagalli L: Immunohistochemical profile of neurotrophins in human cranial dura mater and meningiomas. Oncol Rep. 21:1373–1380. 2009.PubMed/NCBI

4 

Hamel W, Westphal M, Szönyi E, Escandón E and Nikolics K: Neurotrophin gene expression by cell lines derived from human gliomas. J Neurosci Res. 34:147–157. 1993. View Article : Google Scholar : PubMed/NCBI

5 

Zhou XF, Song XY, Zhong JH, Barati S, Zhou FH and Johnson SM: Distribution and localization of pro-brain-derived neurotrophic factor-like immunoreactivity in the peripheral and central nervous system of the adult rat. J Neurochem. 91:704–715. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Seidah NG and Chretien M: Proprotein and prohormone convertases: A family of subtilases generating diverse bioactive polypeptides. Brain Res. 848:45–62. 1999. View Article : Google Scholar : PubMed/NCBI

7 

Barker PA: Whither proBDNF? Nat Neurosci. 12:105–106. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Teng HK, Teng KK, Lee R, Wright S, Tevar S, Almeida RD, Kermani P, Torkin R, Chen ZY, Lee FS, Kraemer RT, et al: ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. J Neurosci. 25:5455–5463. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Kenchappa RS, Zampieri N, Chao MV, et al: Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons. Neuron. 50:219–232. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Fan YJ, Wu LL, Li HY, Wang YJ and Zhou XF: Differential effects of pro-BDNF on sensory neurons after sciatic nerve transection in neonatal rats. Eur J Neurosci. 27:2380–2390. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Woo NH, Teng HK, Siao CJ, Chiaruttini C, Pang PT, Milner TA, Hempstead BL and Lu B: Activation of p75NTR by proBDNF facilitates hippocampal long-term depression. Nat Neurosci. 8:1069–1077. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Lu B: Pro-region of neurotrophins: Role in synaptic modulation. Neuron. 39:735–738. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Lu B, Pang PT and Woo NH: The yin and yang of neurotrophin action. Nat Rev Neurosci. 6:603–614. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Koshimizu H, Hazama S, Hara T, et al: Distinct signaling pathways of precursor BDNF and mature BDNF in cultured cerebellar granule neurons. Neurosci Lett. 473:229–232. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Sun Y, Lim Y, Li F, Liu S, Lu JJ, Haberberger R, Zhong JH and Zhou XF: ProBDNF collapses neurite outgrowth of primary neurons by activating RhoA. PLoS One. 7:e358832012. View Article : Google Scholar : PubMed/NCBI

16 

Xiong J, Zhou L, Yang M, Lim Y, Zhu YH, Fu DL, Li ZW, Zhong JH, Xiao ZC and Zhou XF: ProBDNF and its receptors are upregulated in glioma and inhibit the growth of glioma cells in vitro. Neuro Oncol. 15:990–1007. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Xiong J, Zhou L, Lim Y, Yang M, Zhu YH, Li ZW, Zhou FH, Xiao ZC and Zhou XF: Mature BDNF promotes the growth of glioma cells in vitro. Oncol Rep. 30:2719–2724. 2013.PubMed/NCBI

18 

Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW and Kleihues P: The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 114:97–109. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta Delta C (T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Zhou L, Xiong J, Lim Y, Ruan Y, Huang C, Zhu Y, Zhong JH, Xiao Z and Zhou XF: Upregulation of blood proBDNF and its receptors in major depression. J Affect Disord. 150:776–784. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Assimakopoulou M, Kondyli M, Gatzounis G, Maraziotis T and Varakis J: Neurotrophin receptors expression and JNK pathway activation in human astrocytomas. BMC Cancer. 7:2022007. View Article : Google Scholar : PubMed/NCBI

22 

Hagemann C, Anacker J, Ernestus RI and Vince GH: A complete compilation of matrix metalloproteinase expression in human malignant gliomas. World J Clin Oncol. 3:67–79. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Salmaggi A, Croci D, Prina P, Cajola L, Pollo B, Marras CE, Ciusani E, Silvani A, Boiardi A and Sciacca FL: Production and post-surgical modification of VEGF, tPA and PAI-1 in patients with glioma. Cancer Biol Ther. 5:204–209. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xiong J, Zhou L, Lim Y, Yang M, Zhu YH, Li ZW, Fu DL and Zhou XF: Mature brain-derived neurotrophic factor and its receptor TrkB are upregulated in human glioma tissues. Oncol Lett 10: 223-227, 2015.
APA
Xiong, J., Zhou, L., Lim, Y., Yang, M., Zhu, Y., Li, Z. ... Zhou, X. (2015). Mature brain-derived neurotrophic factor and its receptor TrkB are upregulated in human glioma tissues. Oncology Letters, 10, 223-227. https://doi.org/10.3892/ol.2015.3181
MLA
Xiong, J., Zhou, L., Lim, Y., Yang, M., Zhu, Y., Li, Z., Fu, D., Zhou, X."Mature brain-derived neurotrophic factor and its receptor TrkB are upregulated in human glioma tissues". Oncology Letters 10.1 (2015): 223-227.
Chicago
Xiong, J., Zhou, L., Lim, Y., Yang, M., Zhu, Y., Li, Z., Fu, D., Zhou, X."Mature brain-derived neurotrophic factor and its receptor TrkB are upregulated in human glioma tissues". Oncology Letters 10, no. 1 (2015): 223-227. https://doi.org/10.3892/ol.2015.3181
Copy and paste a formatted citation
x
Spandidos Publications style
Xiong J, Zhou L, Lim Y, Yang M, Zhu YH, Li ZW, Fu DL and Zhou XF: Mature brain-derived neurotrophic factor and its receptor TrkB are upregulated in human glioma tissues. Oncol Lett 10: 223-227, 2015.
APA
Xiong, J., Zhou, L., Lim, Y., Yang, M., Zhu, Y., Li, Z. ... Zhou, X. (2015). Mature brain-derived neurotrophic factor and its receptor TrkB are upregulated in human glioma tissues. Oncology Letters, 10, 223-227. https://doi.org/10.3892/ol.2015.3181
MLA
Xiong, J., Zhou, L., Lim, Y., Yang, M., Zhu, Y., Li, Z., Fu, D., Zhou, X."Mature brain-derived neurotrophic factor and its receptor TrkB are upregulated in human glioma tissues". Oncology Letters 10.1 (2015): 223-227.
Chicago
Xiong, J., Zhou, L., Lim, Y., Yang, M., Zhu, Y., Li, Z., Fu, D., Zhou, X."Mature brain-derived neurotrophic factor and its receptor TrkB are upregulated in human glioma tissues". Oncology Letters 10, no. 1 (2015): 223-227. https://doi.org/10.3892/ol.2015.3181
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