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July-2015 Volume 10 Issue 1

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Review

The importance of Src signaling in sarcoma (Review)

  • Authors:
    • Quanchi Chen
    • Zifei Zhou
    • Liancheng Shan
    • Hui Zeng
    • Yingqi Hua
    • Zhengdong Cai
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China
  • Pages: 17-22
    |
    Published online on: May 6, 2015
       https://doi.org/10.3892/ol.2015.3184
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Abstract

Src is a tyrosine kinase that is of significance in tumor biology. The present review focuses on Src, its molecular structure, and role in cancer, in addition to its expression and function in sarcoma. In addition, the feasibility of Src as a potential drug target for the treatment of sarcoma is also discussed. Previous studies have suggested that Src has essential functions in cell proliferation, apoptosis, invasion, metastasis and the tumor microenvironment. Thus, it may be a potential target for cancer therapy. Src has been found to enhance proliferation, reduce apoptosis and promote metastasis in certain subtypes of sarcoma, including osteosarcoma, chondrosarcoma and Ewing's sarcoma. Furthermore, a number of novel effective therapeutic agents, such as SI-83, which target Src have been investigated in vitro and in vivo. Bosutinib and dasatinib, which inhibit Src, have been approved by the U.S. Food and Drug Administration for the treatment of chronic myelogenous leukemia. In addition, vandetanib is approved for the treatment of medullary thyroid cancer. Furthermore, the Src inhibitor, saracatinib, is currently in clinical trials for the treatment of a variety of solid tumors, including breast and lung cancers. Thus, Src is considered to be an important factor in sarcoma progression and may present a novel clinical therapeutic target. This review demonstrates the importance and clinical relevance of Src in sarcoma, and discusses a number of small molecular inhibitors of src kinase, such as dasatinib and sarcatinib, which are currently in clinical trials for the treatment of sarcoma patients.
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1 

Valkov A, Kilvaer TK, Sorbye SW, et al: The prognostic impact of Akt isoforms, PI3K and PTEN related to female steroid hormone receptors in soft tissue sarcomas. J Transl Med. 9:2002011. View Article : Google Scholar : PubMed/NCBI

2 

Helman LJ and Meltzer P: Mechanisms of sarcoma development. Nat Rev Cancer. 3:685–694. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Coindre JM: New WHO classification of tumours of soft tissue and bone. Ann Pathol. 32:S115–S116. 2012.(In French). PubMed/NCBI

4 

Klein MJ and Siegal GP: Osteosarcoma: anatomic and histologic variants. Am J Clin Pathol. 125:555–581. 2006. View Article : Google Scholar : PubMed/NCBI

5 

de Bruijn DR, Allander SV, van Dijk AH, et al: The synovial-sarcoma-associated SS18-SSX2 fusion protein induces epigenetic gene (de)regulation. Cancer Res. 66:9474–9482. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Sun Y, Gao D, Liu Y, Huang J, Lessnick S and Tanaka S: IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1. Oncogene. 25:1042–1052. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Kashima TG, Gamage NG, Dirksen U, Gibbons CL, Ostlere SJ and Athanasou NA: Localized Ewing sarcoma of the tibia. Clin Sarcoma Res. 3:22013. View Article : Google Scholar : PubMed/NCBI

8 

Choi EY, Gardner JM, Lucas DR, McHugh JB and Patel RM: Ewing sarcoma. Semin Diagn Pathol. 31:39–47. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Kämmerer PW, Shabazfar N, Vorkhshori Makoie N, Moergel M and Al-Nawas B: Clinical, therapeutic and prognostic features of osteosarcoma of the jaws - experience of 36 cases. J Craniomaxillofac Surg. 40:541–548. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Steen S and Stephenson G: Current treatment of soft tissue sarcoma. In: Proc (Bayl Univ Med Cent). 21. pp. 392–396. 2008; PubMed/NCBI

11 

von Mehren M, Randall RL, Benjamin RS, et al: National Comprehensive Cancer Network: Soft tissue sarcoma, version 2.2014. J Natl Compr Canc Netw. 12:473–483. 2014.PubMed/NCBI

12 

Clark MA, Fisher C, Judson I and Thomas JM: Soft-tissue sarcomas in adults. N Engl J Med. 353:701–711. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Demicco EG, Maki RG, Lev DC and Lazar AJ: New therapeutic targets in soft tissue sarcoma. Adv Anat Pathol. 19:170–180. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Byeon SE, Yi YS, Oh J, Yoo BC, Hong S and Cho JY: The role of Src kinase in macrophage-mediated inflammatory responses. Mediators Inflamm. 2012:5129262012.PubMed/NCBI

15 

Levinson WE, Varmus HE, Garapin AC and Bishop JM: DNA of Rous sarcoma virus: its nature and significance. Science. 175:76–78. 1972. View Article : Google Scholar : PubMed/NCBI

16 

Gojis O, Rudraraju B, Gudi M, et al: The role of SRC-3 in human breast cancer. Nat Rev Clin Oncol. 7:83–89. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Boggon TJ and Eck MJ: Structure and regulation of Src family kinases. Oncogene. 23:7918–7927. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Guarino M: Src signaling in cancer invasion. J Cell Physiol. 223:14–26. 2010.PubMed/NCBI

19 

Hunter T and Sefton BM: Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. In: Proc Natl Acad Sci USA. 77. pp. 1311–1315. 1980; View Article : Google Scholar : PubMed/NCBI

20 

Roskoski R Jr: Src kinase regulation by phosphorylation and dephosphorylation. Biochem Biophys Res Commun. 331:1–14. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Bjorge JD, Jakymiw A and Fujita DJ: Selected glimpses into the activation and function of Src kinase. Oncogene. 19:5620–5635. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Zheng XM, Resnick RJ and Shalloway D: A phosphotyrosine displacement mechanism for activation of Src by PTPalpha. EMBO J. 19:964–978. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Cooper JA, Gould KL, Cartwright CA and Hunter T: Tyr527 is phosphorylated in pp60c-src: implications for regulation. Science. 231:1431–1434. 1986. View Article : Google Scholar : PubMed/NCBI

24 

Levin VA: Basis and importance of Src as a target in cancer. Cancer Treat Res. 119:89–119. 2004.PubMed/NCBI

25 

Sirvent A, Benistant C and Roche S: Oncogenic signaling by tyrosine kinases of the SRC family in advanced colorectal cancer. Am J Cancer Res. 2:357–371. 2012.PubMed/NCBI

26 

Cao M, Hou D, Liang H, et al: miR-150 promotes the proliferation and migration of lung cancer cells by targeting SRC kinase signalling inhibitor 1. Eur J Cancer. 50:1013–1024. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Roskoski R Jr: Src protein-tyrosine kinase structure and regulation. Biochem Biophys Res Commun. 324:1155–1164. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Zhang S, Huang WC, Zhang L, et al: SRC family kinases as novel therapeutic targets to treat breast cancer brain metastases. Cancer Res. 73:5764–5774. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Gargalionis AN, Karamouzis MV and Papavassiliou AG: The molecular rationale of Src inhibition in colorectal carcinomas. Int J Cancer. 134:2019–2029. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Je DW, O YM, Ji YG, Cho Y and Lee DH: The inhibition of SRC family kinase suppresses pancreatic cancer cell proliferation, migration, and invasion. Pancreas. 43:768–776. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Saini S, Majid S, Shahryari V, et al: Regulation of SRC Kinases by microRNA-3607 located in a frequently deleted locus in prostate cancer. Mol Cancer Ther. 13:1952–1963. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Balkwill F: The significance of cancer cell expression of the chemokine receptor CXCR4. Semin Cancer Biol. 14:171–179. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Kulbe H, Levinson NR, Balkwill F and Wilson JL: The chemokine network in cancer - much more than directing cell movement. Int J Dev Biol. 48:489–496. 2004. View Article : Google Scholar : PubMed/NCBI

34 

Bjorge JD, Pang A and Fujita DJ: Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell lines. J Biol Chem. 275:41439–41446. 2000. View Article : Google Scholar : PubMed/NCBI

35 

Dehm SM and Bonham K: SRC gene expression in human cancer: the role of transcriptional activation. Biochem Cell Biol. 82:263–274. 2004. View Article : Google Scholar : PubMed/NCBI

36 

Mirmohammadsadegh A, Hassan M, Bardenheuer W, et al: STAT5 phosphorylation in malignant melanoma is important for survival and is mediated through SRC and JAK1 kinases. J Invest Dermatol. 126:2272–2280. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Niu G, Bowman T, Huang M, et al: Roles of activated Src and Stat3 signaling in melanoma tumor cell growth. Oncogene. 21:7001–7010. 2002. View Article : Google Scholar : PubMed/NCBI

38 

Song L, Morris M, Bagui T, Lee FY, Jove R and Haura EB: Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res. 66:5542–5548. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Chen Z, Lee FY, Bhalla KN and Wu J: Potent inhibition of platelet-derived growth factor-induced responses in vascular smooth muscle cells by BMS-354825 (dasatinib). Mol Pharmacol. 69:1527–1533. 2006. View Article : Google Scholar : PubMed/NCBI

40 

Schittenhelm MM, Shiraga S, Schroeder A, et al: Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies. Cancer Res. 66:473–481. 2006. View Article : Google Scholar : PubMed/NCBI

41 

Nakata Y, Tomkowicz B, Gewirtz AM and Ptasznik A: Integrin inhibition through Lyn-dependent cross talk from CXCR4 chemokine receptors in normal human CD34+ marrow cells. Blood. 107:4234–4239. 2006. View Article : Google Scholar : PubMed/NCBI

42 

Chen YY, Malik M, Tomkowicz BE, Collman RG and Ptasznik A: BCR-ABL1 alters SDF-1alpha-mediated adhesive responses through the beta2 integrin LFA-1 in leukemia cells. Blood. 111:5182–5186. 2008. View Article : Google Scholar : PubMed/NCBI

43 

Smolinska MJ, Page TH, Urbaniak AM, Mutch BE and Horwood NJ: Hck tyrosine kinase regulates TLR4-induced TNF and IL-6 production via AP-1. J Immunol. 187:6043–6051. 2011. View Article : Google Scholar : PubMed/NCBI

44 

Lutz MP, Esser IB, Flossmann-Kast BB, et al: Overexpression and activation of the tyrosine kinase Src in human pancreatic carcinoma. Biochem Biophys Res Commun. 243:503–508. 1998. View Article : Google Scholar : PubMed/NCBI

45 

Shor AC, Keschman EA, Lee FY, et al: Dasatinib inhibits migration and invasion in diverse human sarcoma cell lines and induces apoptosis in bone sarcoma cells dependent on SRC kinase for survival. Cancer Res. 67:2800–2808. 2007. View Article : Google Scholar : PubMed/NCBI

46 

Michels S, Trautmann M, Sievers E, et al: SRC signaling is crucial in the growth of synovial sarcoma cells. Cancer Res. 73:2518–2528. 2013. View Article : Google Scholar : PubMed/NCBI

47 

Díaz-Montero CM, Wygant JN and McIntyre BW: PI3-K/Akt-mediated anoikis resistance of human osteosarcoma cells requires Src activation. Eur J Cancer. 42:1491–1500. 2006. View Article : Google Scholar : PubMed/NCBI

48 

Villacis RA, Silveira SM, Barros-Filho MC, et al: Gene expression profiling in leiomyosarcomas and undifferentiated pleomorphic sarcomas: SRC as a new diagnostic marker. PLoS One. 9:e1022812014. View Article : Google Scholar : PubMed/NCBI

49 

Bai Y, Li J, Fang B, et al: Phosphoproteomics identifies driver tyrosine kinases in sarcoma cell lines and tumors. Cancer Res. 72:2501–2511. 2012. View Article : Google Scholar : PubMed/NCBI

50 

Geng S, Wang X, Xu X, et al: Steroid receptor co-activator-3 promotes osteosarcoma progression through up-regulation of FoxM1. Tumour Biol. 35:3087–3094. 2014. View Article : Google Scholar : PubMed/NCBI

51 

Scully SP, Layfield LJ and Harrelson JM: Prognostic markers in chondrosarcoma: evaluation of cell proliferation and of regulators of the cell cycle. Sarcoma. 1:79–87. 1997. View Article : Google Scholar : PubMed/NCBI

52 

Watanabe T, Tsuda M, Tanaka S, et al: Adaptor protein Crk induces Src-dependent activation of p38 MAPK in regulation of synovial sarcoma cell proliferation. Mol Cancer Res. 7:1582–1592. 2009. View Article : Google Scholar : PubMed/NCBI

53 

Watanabe T, Tsuda M, Makino Y, et al: Adaptor molecule Crk is required for sustained phosphorylation of Grb2-associated binder 1 and hepatocyte growth factor-induced cell motility of human synovial sarcoma cell lines. Mol Cancer Res. 4:499–510. 2006. View Article : Google Scholar : PubMed/NCBI

54 

Mazzone M and Comoglio PM: The Met pathway: master switch and drug target in cancer progression. FASEB J. 20:1611–1621. 2006. View Article : Google Scholar : PubMed/NCBI

55 

Spreafico A, Schenone S, Serchi T, et al: Antiproliferative and proapoptotic activities of new pyrazolo[3,4-d]pyrimidine derivative Src kinase inhibitors in human osteosarcoma cells. FASEB J. 22:1560–1571. 2008.PubMed/NCBI

56 

Hingorani P, Zhang W, Gorlick R and Kolb EA: Inhibition of Src phosphorylation alters metastatic potential of osteosarcoma in vitro but not in vivo. Clin Cancer Res. 15:3416–3422. 2009. View Article : Google Scholar : PubMed/NCBI

57 

Horng CT, Shieh PC, Tan TW, Yang WH and Tang CH: Paeonol suppresses chondrosarcoma metastasis through up-regulation of miR-141 by modulating PKCδ and c-Src signaling pathway. Int J Mol Sci. 15:11760–11772. 2014. View Article : Google Scholar : PubMed/NCBI

58 

Wu CM, Li TM, Tan TW, Fong YC and Tang CH: Berberine Reduces the Metastasis of Chondrosarcoma by Modulating the α v β 3 Integrin and the PKC δ, c-Src, and AP-1 Signaling Pathways. Evid Based Complement Alternat Med. 2013:4231642013.PubMed/NCBI

59 

van Oosterwijk JG, van Ruler MA, Briaire-de Bruijn IH, et al: Src kinases in chondrosarcoma chemoresistance and migration: dasatinib sensitises to doxorubicin in TP53 mutant cells. Br J Cancer. 109:1214–1222. 2013. View Article : Google Scholar : PubMed/NCBI

60 

Guarino M: Epithelial-mesenchymal transition and tumour invasion. Int J Biochem Cell Biol. 39:2153–2160. 2007. View Article : Google Scholar : PubMed/NCBI

61 

Boyer B, Bourgeois Y and Poupon MF: Src kinase contributes to the metastatic spread of carcinoma cells. Oncogene. 21:2347–2356. 2002. View Article : Google Scholar : PubMed/NCBI

62 

Huang WS, Wang RJ, Ding JL, et al: Caveolin-1: a novel biomarker for prostate cancer. Zhonghua Nan Ke Xue. 18:635–638. 2012.(In Chinese). PubMed/NCBI

63 

Mercier I and Lisanti MP: Caveolin-1 and breast cancer: a new clinical perspective. Adv Exp Med Biol. 729:83–94. 2012.PubMed/NCBI

64 

Cantiani L, Manara MC, Zucchini C, et al: Caveolin-1 reduces osteosarcoma metastases by inhibiting c-Src activity and met signaling. Cancer Res. 67:7675–7685. 2007. View Article : Google Scholar : PubMed/NCBI

65 

Manara MC, Bernard G, Lollini PL, et al: CD99 acts as an oncosuppressor in osteosarcoma. Mol Biol Cell. 17:1910–1921. 2006. View Article : Google Scholar : PubMed/NCBI

66 

Scotlandi K, Zuntini M, Manara MC, et al: CD99 isoforms dictate opposite functions in tumour malignancy and metastases by activating or repressing c-Src kinase activity. Oncogene. 26:6604–6618. 2007. View Article : Google Scholar : PubMed/NCBI

67 

Abraham J, Chua YX, Glover JM, et al: An adaptive Src-PDGFRA-Raf axis in rhabdomyosarcoma. Biochem Biophys Res Commun. 426:363–368. 2012. View Article : Google Scholar : PubMed/NCBI

68 

Homsi J, Cubitt C and Daud A: The Src signaling pathway: a potential target in melanoma and other malignancies. Expert Opin Ther Targets. 11:91–100. 2007. View Article : Google Scholar : PubMed/NCBI

69 

Creedon H and Brunton VG: Src kinase inhibitors: promising cancer therapeutics? Crit Rev Oncog. 17:145–159. 2012. View Article : Google Scholar : PubMed/NCBI

70 

Molina JR, Foster NR, Reungwetwattana T, et al: A phase II trial of the Src-kinase inhibitor saracatinib after four cycles of chemotherapy for patients with extensive stage small cell lung cancer: NCCTG trial N-0621. Lung Cancer. 85:245–250. 2014. View Article : Google Scholar : PubMed/NCBI

71 

Taylor JW, Dietrich J, Gerstner ER, et al: Phase 2 study of bosutinib, a Src inhibitor, in adults with recurrent glioblastoma. J Neurooncol. Nov 20–2014.(Epub ahead of print).

72 

Montero JC, Seoane S, Ocaña A and Pandiella A: Inhibition of SRC family kinases and receptor tyrosine kinases by dasatinib: possible combinations in solid tumors. Clin Cancer Res. 17:5546–5552. 2011. View Article : Google Scholar : PubMed/NCBI

73 

Schrage YM, Briaire-de Bruijn IH, de Miranda NF, et al: Kinome profiling of chondrosarcoma reveals SRC-pathway activity and dasatinib as option for treatment. Cancer Res. 69:6216–6222. 2009. View Article : Google Scholar : PubMed/NCBI

74 

Musumeci F, Schenone S, Brullo C and Botta M: An update on dual Src/Abl inhibitors. Future Med Chem. 4:799–822. 2012. View Article : Google Scholar : PubMed/NCBI

75 

Girotti MR, Lopes F, Preece N, et al: Paradox-Breaking RAF Inhibitors that Also Target SRC Are Effective in Drug-Resistant BRAF Mutant Melanoma. Cancer Cell. 27:85–96. 2015. View Article : Google Scholar : PubMed/NCBI

76 

Rotert JV, Leupold J, Hohenberger P, Nowak K and Allgayer H: Src activity is increased in gastrointestinal stromal tumors - analysis of associations with clinical and other molecular tumor characteristics. J Surg Oncol. 109:597–605. 2014. View Article : Google Scholar : PubMed/NCBI

77 

Qayyum T, McArdle PA, Lamb GW, et al: Expression and prognostic significance of Src family members in renal clear cell carcinoma. Br J Cancer. 107:856–863. 2012. View Article : Google Scholar : PubMed/NCBI

78 

Sell H, Habich C and Eckel J: Adaptive immunity in obesity and insulin resistance. Nat Rev Endocrinol. 8:709–716. 2012. View Article : Google Scholar : PubMed/NCBI

79 

Spaeth E, Klopp A, Dembinski J, Andreeff M and Marini F: Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells. Gene Ther. 15:730–738. 2008. View Article : Google Scholar : PubMed/NCBI

80 

Hemmerle T, Probst P, Giovannoni L, Green AJ, Meyer T and Neri D: The antibody-based targeted delivery of TNF in combination with doxorubicin eradicates sarcomas in mice and confers protective immunity. Br J Cancer. 109:1206–1213. 2013. View Article : Google Scholar : PubMed/NCBI

81 

Spitaleri G, Berardi R, Pierantoni C, et al: Phase I/II study of the tumour-targeting human monoclonal antibody-cytokine fusion protein L19-TNF in patients with advanced solid tumours. J Cancer Res Clin Oncol. 139:447–455. 2013. View Article : Google Scholar : PubMed/NCBI

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Spandidos Publications style
Chen Q, Zhou Z, Shan L, Zeng H, Hua Y and Cai Z: The importance of Src signaling in sarcoma (Review). Oncol Lett 10: 17-22, 2015.
APA
Chen, Q., Zhou, Z., Shan, L., Zeng, H., Hua, Y., & Cai, Z. (2015). The importance of Src signaling in sarcoma (Review). Oncology Letters, 10, 17-22. https://doi.org/10.3892/ol.2015.3184
MLA
Chen, Q., Zhou, Z., Shan, L., Zeng, H., Hua, Y., Cai, Z."The importance of Src signaling in sarcoma (Review)". Oncology Letters 10.1 (2015): 17-22.
Chicago
Chen, Q., Zhou, Z., Shan, L., Zeng, H., Hua, Y., Cai, Z."The importance of Src signaling in sarcoma (Review)". Oncology Letters 10, no. 1 (2015): 17-22. https://doi.org/10.3892/ol.2015.3184
Copy and paste a formatted citation
x
Spandidos Publications style
Chen Q, Zhou Z, Shan L, Zeng H, Hua Y and Cai Z: The importance of Src signaling in sarcoma (Review). Oncol Lett 10: 17-22, 2015.
APA
Chen, Q., Zhou, Z., Shan, L., Zeng, H., Hua, Y., & Cai, Z. (2015). The importance of Src signaling in sarcoma (Review). Oncology Letters, 10, 17-22. https://doi.org/10.3892/ol.2015.3184
MLA
Chen, Q., Zhou, Z., Shan, L., Zeng, H., Hua, Y., Cai, Z."The importance of Src signaling in sarcoma (Review)". Oncology Letters 10.1 (2015): 17-22.
Chicago
Chen, Q., Zhou, Z., Shan, L., Zeng, H., Hua, Y., Cai, Z."The importance of Src signaling in sarcoma (Review)". Oncology Letters 10, no. 1 (2015): 17-22. https://doi.org/10.3892/ol.2015.3184
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