Pregnancy-induced hypertension caused by all-trans retinoic acid treatment in acute promyelocytic leukemia. A case report

  • Authors:
    • Kui Song
    • Min Li
  • View Affiliations

  • Published online on: May 7, 2015     https://doi.org/10.3892/ol.2015.3190
  • Pages: 364-366
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Abstract

A 23-year-old pregnant female presented with fever and diarrhea during the sixth month of gestation. The patient was diagnosed with acute promyelocytic leukemia (APL) at 26 weeks gestation and was treated with all‑trans retinoic acid (ATRA) at an initial dose of 45 mg/m2/day, which was reduced to 25 mg/m2/day 14 days later. The patient experienced chest distress, polypnea, hypertension, general dropsy and dysfunction of the kidneys and heart on day 3 of the treatment, which suggested pregnancy‑induced hypertension. Intrauterine fetal demise was apparent on day 8. A cesarean delivery was performed, however, intrauterine fetal mortality had occurred. A favorable outcome was achieved for the patient following treatment, although hematological complete remission was slow. To the best of our knowledge, the present study is the first to describe an APL patient with pregnancy‑induced hypertension following treatment with ATRA, and thus ATRA remains a suitable for therapy for APL during pregnancy.
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July-2015
Volume 10 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Song K and Song K: Pregnancy-induced hypertension caused by all-trans retinoic acid treatment in acute promyelocytic leukemia. A case report. Oncol Lett 10: 364-366, 2015
APA
Song, K., & Song, K. (2015). Pregnancy-induced hypertension caused by all-trans retinoic acid treatment in acute promyelocytic leukemia. A case report. Oncology Letters, 10, 364-366. https://doi.org/10.3892/ol.2015.3190
MLA
Song, K., Li, M."Pregnancy-induced hypertension caused by all-trans retinoic acid treatment in acute promyelocytic leukemia. A case report". Oncology Letters 10.1 (2015): 364-366.
Chicago
Song, K., Li, M."Pregnancy-induced hypertension caused by all-trans retinoic acid treatment in acute promyelocytic leukemia. A case report". Oncology Letters 10, no. 1 (2015): 364-366. https://doi.org/10.3892/ol.2015.3190