Significance of gastrin‑releasing peptide in ovarian cancer ES2 cells

  • Authors:
    • Yanyan Jia
    • Huirong Shi
    • Dongmei Fan
  • View Affiliations

  • Published online on: May 20, 2015     https://doi.org/10.3892/ol.2015.3240
  • Pages: 359-363
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The present study aimed to investigate the effect of gastrin‑releasing peptide (GRP) on the proliferation and invasion of ovarian cancer ES2 cells. The ovarian cancer ES2 cells were transfected with small interfering RNA against GRP. Cell proliferation was assessed using the Trypan blue assay, apoptosis was determined using propidium iodide/fluorescein isothiocyanate and flow cytometry, and the invasion ability was detected using the Transwell assay. The results revealed that the expression of GRP significantly decreased following transfection with GRP‑short hairpin RNA. Furthermore, the silencing of GRP resulted in increased apoptosis and a reduced invasive ability of the ES2 cells. It was concluded that GRP may regulate the proliferation and migration of human ovarian cancer cells, which indicates that GRP may be a potential novel target for the treatment of ovarian cancer.
View Figures
View References

Related Articles

Journal Cover

July-2015
Volume 10 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Jia Y, Shi H and Fan D: Significance of gastrin‑releasing peptide in ovarian cancer ES2 cells. Oncol Lett 10: 359-363, 2015
APA
Jia, Y., Shi, H., & Fan, D. (2015). Significance of gastrin‑releasing peptide in ovarian cancer ES2 cells. Oncology Letters, 10, 359-363. https://doi.org/10.3892/ol.2015.3240
MLA
Jia, Y., Shi, H., Fan, D."Significance of gastrin‑releasing peptide in ovarian cancer ES2 cells". Oncology Letters 10.1 (2015): 359-363.
Chicago
Jia, Y., Shi, H., Fan, D."Significance of gastrin‑releasing peptide in ovarian cancer ES2 cells". Oncology Letters 10, no. 1 (2015): 359-363. https://doi.org/10.3892/ol.2015.3240