Lung cancer with spontaneous regression of primary and metastatic sites: A case report

Ogawa,Ryoko; Watanabe,Hiroko; Yazaki,Kai; Fujita,Kazutaka; Tsunoda,Yoshiya; Nakazawa,Kensuke; Homma,Shinsuke; Kagohashi,Katsunori; Satoh,Hiroaki; Hizawa,Nobuyuki

doi:10.3892/ol.2015.3243

July-2015 Volume 10 Issue 1

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July-2015 Volume 10 Issue 1

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Case Report

Lung cancer with spontaneous regression of primary and metastatic sites: A case report

Authors:
- Ryoko Ogawa
- Hiroko Watanabe
- Kai Yazaki
- Kazutaka Fujita
- Yoshiya Tsunoda
- Kensuke Nakazawa
- Shinsuke Homma
- Katsunori Kagohashi
- Hiroaki Satoh
- Nobuyuki Hizawa
View Affiliations / Copyright

Affiliations: Division of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Mito, Ibaraki 310‑0015, Japan, Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito, Ibaraki 310‑0015, Japan
Pages: 550-552
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Published online on: May 20, 2015

https://doi.org/10.3892/ol.2015.3243
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Abstract

Partial or complete spontaneous cancer regression is a rare phenomenon, particularly in patients with lung cancer. This is the case report of a patient with lung cancer who exhibited spontaneous regression of the primary as well as metastatic lesions, without receiving any treatment. Spontaneous regression commenced within a week of obtaining pathological specimens by transbronchial and percutaneous biopsies from the primary lesion and metastatic lymph nodes of the left side of the neck. The reason for this phenomenon is unknown; however, we hypothesized that there may be an immunological association between the stimulus of the biopsies and the spontaneous regression. This patient should be closely followed up to monitor the clinical course of this unusual case.

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1	Cole WH: Effects to explain spontaneous regression of cancer. J Surg Oncol. 17:201–209. 1981. View Article : Google Scholar : PubMed/NCBI
2	Everson TC and Cole WH: Spontaneous regression of cancer. Philadelphia WB Sounders; 1966
3	Challis GB and Stam HJ: The spontaneous regression of cancer. A review of cases from 1900–1987. Acta Oncol. 29:545–550. 1990. View Article : Google Scholar : PubMed/NCBI
4	Gueron G, De Siervi A and Vazquez E: Key questions in metastasis: new insights in molecular pathways and therapeutic implications. Curr Pharm Biotechnol. 12:1867–1880. 2011. View Article : Google Scholar : PubMed/NCBI
5	Oikawa A, Takahashi H, Ishikawa H, Kurishima K, Kagohashi K and Satoh H: Application of conditional probability analysis to distant metastases from lung cancer. Oncol Lett. 3:629–634. 2012.PubMed/NCBI
6	Nakazawa K, Kurishima K, Tamura T, et al: Specific organ metastases and survival in small cell lung cancer. Oncol Lett. 4:617–620. 2012.PubMed/NCBI
7	Sampath L, Kwon S, Hall MA, Price RE and Sevick-Muraca EM: Detection of cancer metastases with a dual-labeled near-infrared/positron emission tomography imaging agent. Transl Oncol. 3:307–317. 2010. View Article : Google Scholar : PubMed/NCBI
8	Kappauf H, Gallmeier WM and Wunch PH: Complete spontaneous remission in a patient with metastatic non-small-cell lung cancer. Case report, review of literature and discussion of possible biological pathways involved. Ann Oncol. 8:1031–1039. 1997. View Article : Google Scholar : PubMed/NCBI
9	Cafferata MA, Chiaramondia M, Monetti F and Ardizzoni A: Complete spontaneous remission of non-small-cell lung cancer: a case report. Lung Cancer. 45:263–266. 2004. View Article : Google Scholar : PubMed/NCBI
10	Lowy AD Jr and Erickson ER: Spontaneous 19-year regression of oat cell carcinoma with scalene metastasis. Cancer. 58:978–980. 1986. View Article : Google Scholar : PubMed/NCBI
11	Deweerd JH, Hawthorne NJ and Adson MA: Regression of renal cell hepatic metastasis following removal of primary lesions. J Urol. 117:790–792. 1977.PubMed/NCBI
12	Marces SG, Choyke PL, Reiter R, et al: Regression of metastatic renal cell carcinoma after cytoreductive nephrectomy. J Urol. 150:463–466. 1993.PubMed/NCBI
13	Gohji K, Kizaki T and Fujii A: Spontaneous regression of pulmonary metastasis from nonfunctioning adrenocortical carcinoma after removal of the primary lesion: a case report. J Urol. 154:1854–1855. 1995. View Article : Google Scholar : PubMed/NCBI
14	Hammad AM, Paris GR, van Heuven WA, Thompson IM and Fitzsimmons TD: Spontaneous regression of choroidal metastasis from renal cell carcinoma. Am J Ophthalmol. 135:911–913. 2003. View Article : Google Scholar : PubMed/NCBI
15	Miyazaki K, Masuko H, Satoh H and Ohtsuka M: Lung cancer with spontaneous regression of scalp metastasis. Respir Med Extra. 3:83–85. 2007. View Article : Google Scholar
16	Wadsworth SJ, Davies CW, Gray W and Gleeson FV: Spontaneous regression of pulmonary metastases demonstrated by CT. Br J Radiol. 72:304–307. 1999. View Article : Google Scholar : PubMed/NCBI
17	Stoll BA: Spontaneous regression of cancer: new insights. Biotherapy. 4:23–30. 1992. View Article : Google Scholar : PubMed/NCBI
18	Moroda T, Iiai T and Suzuki S: Autologous killing by a population of intermediate T-cell receptor cells and its NK1.1⁺ and NK1.1 subsets, using Fas ligand/Fas molecules. Immunology. 91:219–226. 1997. View Article : Google Scholar : PubMed/NCBI
19	Kawamura T, Seki S and Takeda K: Protective effect of NK1.1⁺ cells as well as NK cells against intraperitoneal tumors in mice. Cell Immunol. 193:219–225. 1999. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Lung cancer with spontaneous regression of primary and metastatic sites: A case report

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