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Review

AKT plays a crucial role in gastric cancer (Review)

  • Authors:
    • Takamitsu Sasaki
    • Yuichi Yamashita
    • Hiroki Kuniyasu
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterological Surgery, Fukuoka University School of Medicine, Fukuoka, Fukuoka 812‑8582, Japan, Department of Molecular Pathology, Nara Medical University, Kashihara, Nara 634‑8521, Japan
  • Pages: 607-611
    |
    Published online on: May 25, 2015
       https://doi.org/10.3892/ol.2015.3260
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Abstract

The AKT protein is involved in the phosphatidylinositol-3 kinase signaling pathway and is a vital regulator of survival, proliferation and differentiation in various types of cells. Helicobacter pylori infection induces epithelial cell proliferation and oxidative stress in chronic gastritis. These alterations lead to telomere shortening, resulting in the activation of telomerase. AKT, in particular, is activated by H. pylori‑induced inflammation. AKT then promotes the expression of human telomerase reverse transcriptase, which encodes a catalytic subunit of telomerase, and induces telomerase activity, an essential component of the process of carcinogenesis. AKT activation is increased in gastric mucosa with carcinogenic properties and is associated with the low survival of patients with gastric cancer. The findings of the present study suggest that AKT is pivotal in gastric carcinogenesis and progression.
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Copy and paste a formatted citation
Spandidos Publications style
Sasaki T, Yamashita Y and Kuniyasu H: AKT plays a crucial role in gastric cancer (Review). Oncol Lett 10: 607-611, 2015.
APA
Sasaki, T., Yamashita, Y., & Kuniyasu, H. (2015). AKT plays a crucial role in gastric cancer (Review). Oncology Letters, 10, 607-611. https://doi.org/10.3892/ol.2015.3260
MLA
Sasaki, T., Yamashita, Y., Kuniyasu, H."AKT plays a crucial role in gastric cancer (Review)". Oncology Letters 10.2 (2015): 607-611.
Chicago
Sasaki, T., Yamashita, Y., Kuniyasu, H."AKT plays a crucial role in gastric cancer (Review)". Oncology Letters 10, no. 2 (2015): 607-611. https://doi.org/10.3892/ol.2015.3260
Copy and paste a formatted citation
x
Spandidos Publications style
Sasaki T, Yamashita Y and Kuniyasu H: AKT plays a crucial role in gastric cancer (Review). Oncol Lett 10: 607-611, 2015.
APA
Sasaki, T., Yamashita, Y., & Kuniyasu, H. (2015). AKT plays a crucial role in gastric cancer (Review). Oncology Letters, 10, 607-611. https://doi.org/10.3892/ol.2015.3260
MLA
Sasaki, T., Yamashita, Y., Kuniyasu, H."AKT plays a crucial role in gastric cancer (Review)". Oncology Letters 10.2 (2015): 607-611.
Chicago
Sasaki, T., Yamashita, Y., Kuniyasu, H."AKT plays a crucial role in gastric cancer (Review)". Oncology Letters 10, no. 2 (2015): 607-611. https://doi.org/10.3892/ol.2015.3260
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