Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
August-2015 Volume 10 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2015 Volume 10 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Microvascular density and endothelial area correlate with Ki-67 proliferative index in surgically-treated pancreatic ductal adenocarcinoma patients

  • Authors:
    • Michele Ammendola
    • Rosario Sacco
    • Ilaria Marech
    • Giuseppe Sammarco
    • Valeria Zuccalà
    • Maria Luposella
    • Rosa Patruno
    • Marcella Giordano
    • Eustachio Ruggieri
    • Nicola Zizzo
    • Cosmo Damiano Gadaleta
    • Girolamo Ranieri
  • View Affiliations / Copyright

    Affiliations: Department of Medical and Surgery Science, Clinical Surgery Unit, University of Catanzaro ‘Magna Graecia’ Medical School, Catanzaro 88100, Italy, Diagnostic and Interventional Radiology Unit with Integrated Section of Translational Medical Oncology, National Cancer Research Centre, ‘Giovanni Paolo II’, Bari 70124, Italy, Department of Health Science, Pathology Unit, University of Catanzaro ‘Magna Graecia’ Medical School, Catanzaro 88100, Italy, Department of Medical and Surgery Science, Cardiovascular Disease Unit, University of Catanzaro ‘Magna Graecia’ Medical School, Catanzaro 88100, Italy, Surgery Unit, National Cancer Research Centre, ‘Giovanni Paolo II’, Bari 70124, Italy, Chair of Pathology, ‘Aldo Moro’ University of Bari, Bari 70010, Italy
  • Pages: 967-971
    |
    Published online on: May 27, 2015
       https://doi.org/10.3892/ol.2015.3286
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Previous experimental and clinical data have indicated that tumour cell proliferation is associated with angiogenesis; in addition, an increased microvascular density (MVD) of tumours has been associated with poor prognosis in solid and haematological malignancies. However, limited data exists regarding the association between tumour cell proliferation and angiogenesis in primary tumour tissue from pancreatic ductal adenocarcinoma (PDAC) patients; therefore, the present study aimed to investigate this association. A series of 31 PDAC patients with stage Tumour (T)2‑3 Node (N)0‑1 Metastasis (M)0 were recruited into the present study and subsequently underwent surgery. PDAC tissue and adjacent normal tissue (ANT), resected during surgery, were evaluated using immunohistochemistry and image analysis methods to determine MVD, endothelial area (EA) and Ki‑67 expression, which is an indicator of cell proliferation rate. The results demonstrated a correlation between the above parameters with each other as well as the main clinico‑pathological features of PDAC. Significant differences were identified in MVD, EA and Ki‑67 proliferation index between PDAC and ANT. It was demonstrated that MVD, EA and Ki‑67 proliferation index were significantly correlated with each other in tumour tissue (r=0.69‑0.81; P=0.001‑0.003). However, no other significant correlations were identified. These data therefore suggested that angiogenesis and cell proliferation rate were significantly increased in PDAC compared with ANT, which provides a biological basis for the potential use of novel combinations of angiogenesis inhibitors and anti-proliferative chemotherapeutic drugs in the treatment of PDAC.
View Figures

Figure 1

Figure 2

View References

1 

Folkman J: Tumor angiogenesis and tissue factor. Nat Med. 2:167–168. 1996. View Article : Google Scholar : PubMed/NCBI

2 

Ranieri G, Coviello M, Chriatti A, et al: Vascular endothelial growth factor assessment in different blood fractions of gastroenterology cancer patients and healthy controls. Oncol Rep. 11:435–439. 2004.PubMed/NCBI

3 

Ranieri G, Labriola A, Achille G, et al: Microvessels density, mast cell density and thymidine phosphorylase expression in oral squamous carcinoma. Int J Oncol. 21:1317–1323. 2002.PubMed/NCBI

4 

Ranieri G, Patruno R, Lionetti A, et al: Endothelial area and micrivascular density in a canine non-Hodgkin's lymphoma: An interspecies model of tumor angiogenesis. Leuk Lymphoma. 46:1639–1643. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Yamazaki K, Nagao T, Yamaguchi T, et al: Expression of basic fibroblast growth factor (FGF-2)-associated with tumour proliferation in human pancreatic carcinoma. Virchows Arch. 431:95–101. 1997. View Article : Google Scholar : PubMed/NCBI

6 

Díaz VM, Planaguma J, Thomson TM, et al: Tissue plasminogen activator is required for the growth, invasion and angiogenesis of pancreatic tumor cells. Gastroenterology. 122:806–819. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Weidner N, Semple JP, Welch WR and Folkman J: Tumour angiogenesis and metastasis - correlation in invasive breast carcinoma. N Engl J Med. 324:1–8. 1991. View Article : Google Scholar : PubMed/NCBI

8 

Soucek L, Lawlor ER, Soto D, et al: Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumours. Nat Med. 13:1211–1218. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Pang B, Fan H, Zhang IY, et al: HMGA1 expression in human gliomas and its correlation with tumor proliferation, invasion and angiogenesis. J Neurooncol. 106:543–549. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Sharma SG, Aggarwal N, Gupta SD, et al: Angiogenesis in renal cell carcinoma: Correlation of microvessel density and microvessel area with other prognostic factors. Int Urol Nephrol. 43:125–129. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Sanci M, Dikis C, Inan S, et al: Immunolocalization of VEGF, VEGF receptors, EGF-R and Ki-67 in leiomyoma, cellular leiomyoma and leiomyosarcoma. Acta Histochem. 113:317–325. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Gravdal K, Halvorsen OJ, Haukaas SA and Akslen LA: Proliferation of immature tumor vessels is a novel marker of clinical progression in prostate cancer. Cancer Res. 69:4708–4715. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Koide N, Saito H, Suzuki A, et al: Clinicopathologic features and histochemical analyses of proliferative activity and angiogenesis in small cell carcinoma of the esophagus. J Gastroenterol. 42:932–938. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Tenderenda M: Potential prognostic value of angiogenesis, cell proliferation and metastasing in patients with surgically treated gastric cancer-current knowledge. Wiad Lek. 59:855–860. 2006.(In Polish). PubMed/NCBI

15 

Imamura M, Yamamoto H, Nakamura N, et al: Prognostic significance of angiogenesis in gastrointestinal stromal tumor. Mod Pathol. 20:529–537. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Fujita S, Nagamachi S, Nishii R, et al: Relationship between cancer cell proliferation, tumour angiogenesis and 201Tl uptake in non-small cell lung cancer. Nucl Med Commun. 27:989–997. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Chen Y, Zhang S, Chen YP and Lin JY: Increased expression of angiogenin in gastric carcinoma in correlation with tumor angiogenesis and proliferation. World J Gastroenterol. 12:5135–5139. 2006.PubMed/NCBI

18 

Patruno R, Zizzo N, Zito AF, et al: Microvascular density and endothelial area correlate with Ki-67 proliferative rate in the canine non-Hodgkin's lymphoma spontaneous model. Leuk Lymphoma. 47:1138–1143. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Schlüter C, Duchrow M, Wohlenberg C, et al: The cell proliferation-associated antigen of antibody Ki-67: A very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining protein. J Cell Biol. 123:513–522. 1993. View Article : Google Scholar : PubMed/NCBI

20 

Kalogeraki A, Tzardi M, Panagiotides I, et al: MIB1 (Ki-67) expression in non-Hodgkin' s lymphomas. Anticancer Res. 17:487–491. 1997.PubMed/NCBI

21 

Stipa F, Lucandri G, Limiti MR, et al: Angiogenesis as a prognostic indicator in pancreatic ductal adenocarcinoma. Anticancer Res. 22:445–449. 2002.PubMed/NCBI

22 

Karademir S, Sökmen S, Terzi C, et al: Tumor angiogenesis as a prognostic predictor in pancreatic cancer. J Hepatobiliary Pancreat Surg. 7:489–495. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Edge SB, Byrd DR, Compton CC, et al: AJCC Cancer Staging Manual. 7th. Springer; New York, NY: pp. 241–249. 2010

24 

Hamilton SR and Aaltonen LA: Pathology and Genetics. Tumours of the Digestive SystemWorld Health Organization Classification of Tumours. International Agency for Research on Cancer (IARC). 3rd. 2. IARC Press; Lyon, France: pp. 1–307. 2000

25 

Ranieri G, Grammatica L, Patruno R, et al: A possible role of thymidine phosphorylase expression and 5-fluorouracil increased sensitivity in oropharyngeal cancer patients. J Cell Mol Med. 11:362–368. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Ranieri G, Labriola A, Achille G, et al: Microvessel density, mast cell density and thymidine phosphorylase expression in oral squamous carcinoma. Int J Oncol. 21:1317–1323. 2002.PubMed/NCBI

27 

Ammendola M, Sacco R, Sammarco G, et al: Mast cells positive to tryptase and C-Kit receptor expressing cells correlates with angiogenesis in gastric cancer patients surgically treated. Gastroenterol Res Pract. 2013:7031632013. View Article : Google Scholar : PubMed/NCBI

28 

Ammendola M, Sacco R, Donato G, et al: Mast Cell positive to tryptase correlates with metastatic lymph nodes in gastrointestinal cancers patients treated surgically. Oncology. 85:111–116. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Ma Y, Hwang RF, Logsdon CD and Ullrich SE: Dynamic mast cell-stromal cell interactions promote growth of pancreatic cancer. Cancer Res. 73:3927–3937. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Wang X, Chen X, Fang J and Yang C: Overexpression of both VEGF-A and VEGF-C in gastric cancer correlates with prognosis and silencing of both is effective to inhibit cancer growth. Int J Clin Exp Pathol. 6:586–597. 2013.PubMed/NCBI

31 

Ammendola M, Zuccalà V, Patruno R, et al: Tryptase-positive mast cells and angiogenesis in keloids: A new post-surgical target for prevention. Updates Surg. 65:53–57. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Patsouras D, Papaxoinis K, Kostakis A, et al: Fibroblast activation protein and its prognostic significance in correlation with vascular endothelial growth factor in pancreatic adenocarcinoma. Mol Med Rep. 11:4585–4590. 2015.PubMed/NCBI

33 

Matsuda Y, Yoshimura H, Suzuki T, et al: Inhibition of fibroblast growth factor receptor 2 attenuates proliferation and invasion of pancreatic cancer. Cancer Sci. 105:1212–1219. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Hong SP, Shin SK, Bang S, et al: Prognostic value of thymidine phosphorylase expression for pancreatic cancer. Hepatogastroenterology. 56:1178–1182. 2009.PubMed/NCBI

35 

Ammendola M, Sacco R, Sammarco G, Donato G, et al: Mast cells density positive to tryptase correlates with angiogenesis in pancreatic ductal adenocarcinoma patients having undergone surgery. Gastroenterol Res Pract. 2014:9519572014. View Article : Google Scholar : PubMed/NCBI

36 

Ranieri G, Mammì M, Donato Di Paola E, et al: Pazopanib a tyrosine kinase inhibitor with strong anti-angiogenetic activity: A new treatment for metastatic soft tissue sarcoma. Crit Rev Oncol Hematol. 89:322–329. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Humbert M, Castéran N, Letard S, et al: Masitinib combined with standard gemcitabine chemotherapy: In vitro and in vivo studies in human pancreatic tumour cell lines and ectopic mouse model. PLoS One. 5:e94302010. View Article : Google Scholar : PubMed/NCBI

38 

Marech I, Patruno R, Zizzo N, et al: Masitinib (AB1010), from canine tumor model to human clinical development: Where we are? Crit Rev Oncol Hematol. 91:98–111. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ammendola M, Sacco R, Marech I, Sammarco G, Zuccalà V, Luposella M, Patruno R, Giordano M, Ruggieri E, Zizzo N, Zizzo N, et al: Microvascular density and endothelial area correlate with Ki-67 proliferative index in surgically-treated pancreatic ductal adenocarcinoma patients. Oncol Lett 10: 967-971, 2015.
APA
Ammendola, M., Sacco, R., Marech, I., Sammarco, G., Zuccalà, V., Luposella, M. ... Ranieri, G. (2015). Microvascular density and endothelial area correlate with Ki-67 proliferative index in surgically-treated pancreatic ductal adenocarcinoma patients. Oncology Letters, 10, 967-971. https://doi.org/10.3892/ol.2015.3286
MLA
Ammendola, M., Sacco, R., Marech, I., Sammarco, G., Zuccalà, V., Luposella, M., Patruno, R., Giordano, M., Ruggieri, E., Zizzo, N., Gadaleta, C. D., Ranieri, G."Microvascular density and endothelial area correlate with Ki-67 proliferative index in surgically-treated pancreatic ductal adenocarcinoma patients". Oncology Letters 10.2 (2015): 967-971.
Chicago
Ammendola, M., Sacco, R., Marech, I., Sammarco, G., Zuccalà, V., Luposella, M., Patruno, R., Giordano, M., Ruggieri, E., Zizzo, N., Gadaleta, C. D., Ranieri, G."Microvascular density and endothelial area correlate with Ki-67 proliferative index in surgically-treated pancreatic ductal adenocarcinoma patients". Oncology Letters 10, no. 2 (2015): 967-971. https://doi.org/10.3892/ol.2015.3286
Copy and paste a formatted citation
x
Spandidos Publications style
Ammendola M, Sacco R, Marech I, Sammarco G, Zuccalà V, Luposella M, Patruno R, Giordano M, Ruggieri E, Zizzo N, Zizzo N, et al: Microvascular density and endothelial area correlate with Ki-67 proliferative index in surgically-treated pancreatic ductal adenocarcinoma patients. Oncol Lett 10: 967-971, 2015.
APA
Ammendola, M., Sacco, R., Marech, I., Sammarco, G., Zuccalà, V., Luposella, M. ... Ranieri, G. (2015). Microvascular density and endothelial area correlate with Ki-67 proliferative index in surgically-treated pancreatic ductal adenocarcinoma patients. Oncology Letters, 10, 967-971. https://doi.org/10.3892/ol.2015.3286
MLA
Ammendola, M., Sacco, R., Marech, I., Sammarco, G., Zuccalà, V., Luposella, M., Patruno, R., Giordano, M., Ruggieri, E., Zizzo, N., Gadaleta, C. D., Ranieri, G."Microvascular density and endothelial area correlate with Ki-67 proliferative index in surgically-treated pancreatic ductal adenocarcinoma patients". Oncology Letters 10.2 (2015): 967-971.
Chicago
Ammendola, M., Sacco, R., Marech, I., Sammarco, G., Zuccalà, V., Luposella, M., Patruno, R., Giordano, M., Ruggieri, E., Zizzo, N., Gadaleta, C. D., Ranieri, G."Microvascular density and endothelial area correlate with Ki-67 proliferative index in surgically-treated pancreatic ductal adenocarcinoma patients". Oncology Letters 10, no. 2 (2015): 967-971. https://doi.org/10.3892/ol.2015.3286
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team