Pleural synovial sarcoma patient treated with combined chemotherapy and Endostar, plus sunitinib maintenance therapy: 
A case report and review of the literature

Teng,Chong; Li,Li; Shen,Weixi; Li,Jingang; Liu,Ying; Jiang,Qiuying; Xin,Tao; Huang,Dayong; Song,Xiaowei; Lv,Yanju; Jin,Yinghua

doi:10.3892/ol.2015.3311

August-2015 Volume 10 Issue 2

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August-2015 Volume 10 Issue 2

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Case Report

Pleural synovial sarcoma patient treated with combined chemotherapy and Endostar, plus sunitinib maintenance therapy: A case report and review of the literature

Authors:
- Chong Teng
- Li Li
- Weixi Shen
- Jingang Li
- Ying Liu
- Qiuying Jiang
- Tao Xin
- Dayong Huang
- Xiaowei Song
- Yanju Lv
- Yinghua Jin
View Affiliations / Copyright

Affiliations: Department of Oncology, The Second Affiliated Clinical Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China, Heilongjiang Academy of Chinese Medicine, Harbin, Heilongjiang 150001, P.R. China
Pages: 1141-1144
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Published online on: June 3, 2015

https://doi.org/10.3892/ol.2015.3311
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Abstract

Synovial sarcoma is a rare, highly malignant soft-tissue tumor that occurs primarily in the extremities. At present, there is no effective clinical treatment for this condition. The present study reports the case of a 49‑year‑old male who was diagnosed with pleural synovial sarcoma and treated with recombinant human endostatin (Endostar) combined with chemotherapy for a total of six cycles, followed by sunitinib maintenance therapy. To the best of our knowledge, this is the first reported use of sunitinib for maintenance therapy in pleural synovial sarcoma. The patient survived for 25 months after the recurrence of the disease following surgery. The results indicate that this combination therapy was effective in the treatment of pleural synovial sarcoma. The present study also briefly reviews the literature on pleural synovial sarcoma, and the features and treatments for this rare case are discussed.

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1	Mankin HJ and Hornicek FJ: Diagnosis, classification, and management of soft tissue sarcomas. Cancer Control. 12:5–21. 2005.PubMed/NCBI
2	Aubry MC, Bridge JA, Wickert R and Tazelaar HD: Primary monophasic synovial sarcoma of the pleura: Five cases confirmed by the presence of SYT-SSX fusion transcript. Am J Surg Pathol. 25:776–781. 2001. View Article : Google Scholar : PubMed/NCBI
3	Gaertner E, Zeren EH, Fleming MV, Colby TV and Travis WD: Biphasic synovial sarcomas arising in the pleural cavity. A clinicopathologic study of five cases. Am J Surg Pathol. 20:36–45. 1996. View Article : Google Scholar : PubMed/NCBI
4	Jawahar DA, Vuletin JC, Gorecki P, Persechino F, Macera M and Magazeh P: Primary biphasic synovial sarcoma of the pleura. Respir Med. 91:568–570. 1997. View Article : Google Scholar : PubMed/NCBI
5	Nicholson AG, Goldstraw P and Fisher C: Synovial sarcoma of the pleura and its differentiation from other primary pleural tumours: A clinicopathological and immunohistochemical review of three cases. Histopathology. 33:508–513. 1998. View Article : Google Scholar : PubMed/NCBI
6	Loscertales J, Triviño A, Gallardo G and Congregado M: Primary monophasic synovial sarcoma of the pleura: Diagnosis and treatment. Interact Cardiovasc Thorac Surg. 12:885–887. 2011. View Article : Google Scholar : PubMed/NCBI
7	Nishiyama N, Iwata T, Izumi N, Tsukioka T, Nagano K and Suehiro S: Aggressive repeat surgery for a recurrent synovial sarcoma in the pleura. Ann Thorac Cardiovasc Surg. 15:46–49. 2009.PubMed/NCBI
8	O'Reilly MS, Boehm T, Shing Y, et al: Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell. 88:277–285. 1997. View Article : Google Scholar : PubMed/NCBI
9	Zhuo W, Chen Y, Song X and Luo Y: Endostatin specifically targets both tumor blood vessels and lymphatic vessels. Front Med. 5:336–340. 2011. View Article : Google Scholar : PubMed/NCBI
10	Cardoso F, Canon JL, Amadori D, et al: An exploratory study of sunitinib in combination with docetaxel and trastuzumab as first-line therapy for HER2-positive metastatic breast cancer. Breast. 21:716–723. 2012. View Article : Google Scholar : PubMed/NCBI
11	Corn PG, Song DY, Heath E, et al: Sunitinib plus androgen deprivation and radiation therapy for patients with localized high-risk prostate cancer: results from a multi-institutional phase 1 study. Int J Radiat Oncol Biol Phys. 86:540–545. 2013. View Article : Google Scholar : PubMed/NCBI
12	Modest DP, Camaj P, Heinemann V, et al: KRAS allel-specific activity of sunitinib in an isogenic disease model of colorectal cancer. J Cancer Res Clin Oncol. 139:953–961. 2013. View Article : Google Scholar : PubMed/NCBI
13	Waqar SN, Gopalan PK, Williams K, Devarakonda S and Govindan R: A phase I trial of sunitinib and rapamycin in patients with advanced non-small cell lung cancer. Chemotherapy. 59:8–13. 2013. View Article : Google Scholar : PubMed/NCBI
14	George S, Merriam P, Maki RG, et al: Multicenter phase II trial of sunitinib in the treatment of nongastrointestinal stromal tumor sarcomas. J Clin Oncol. 27:3154–3160. 2009. View Article : Google Scholar : PubMed/NCBI