Inability of PET/CT to identify a primary sinonasal inverted papilloma with squamous cell carcinoma in a patient with a submandibular lymph node metastasis: A case report

Zhang,Si‑Cong; Wei,Lin; Zhou,Shui‑Hong; Zhao,Kui

doi:10.3892/ol.2015.3328

August-2015 Volume 10 Issue 2

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August-2015 Volume 10 Issue 2

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Case Report Open Access

Inability of PET/CT to identify a primary sinonasal inverted papilloma with squamous cell carcinoma in a patient with a submandibular lymph node metastasis: A case report

Authors:
- Si‑Cong Zhang
- Lin Wei
- Shui‑Hong Zhou
- Kui Zhao
View Affiliations / Copyright

Affiliations: Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China, Department of Positron Emission Tomography/Computed Tomography Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China

Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 749-753
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Published online on: June 5, 2015

https://doi.org/10.3892/ol.2015.3328
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Abstract

The present study describes the first reported case of a sinonasal inverted papilloma (IP) with squamous cell carcinoma (SCC) that presented as a cancer of unknown primary in the English‑language literature. In July 2010, a 66‑year old male presented with a 6‑month history of a painless, progressive mass in the right submandibular region. Physical examination revealed a 3x4‑cm smooth, non-tender mass and subsequently, excision of the right submandibular gland was performed. Post‑operative pathological examination indicated poorly‑differentiated SCC of the submandibular lymph node. Positron‑emission tomography/computed tomography (PET/CT) was unable to identify the primary tumour site in this case, and 14 months later the patient presented with nasal obstruction, leading to the diagnosis of right sinonasal IP with coexistent SCC. The patient received pre‑operative radiotherapy, a right total maxillectomy and post‑operative radiotherapy. However, the patient succumbed to a distant metastasis 37 months after the initial presentation. 18F‑fluorodeoxyglucose uptake on PET/CT may be not a reliable predictor of malignancy in sinonasal IPs. Therefore, we suggest emphasis of the use of multiple biopsies for suspected sinonasal IPs in order to improve diagnostic accuracy.

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1	Tanvetyanon T, Qin D, Padhya T, Kapoor R, McCaffrey J and Trotti A: Survival outcomes of squamous cell carcinoma arising from sinonasal inverted papilloma: Report of 6 cases with systematic review and pooled analysis. Am J Otolaryngol. 30:38–43. 2009. View Article : Google Scholar : PubMed/NCBI
2	Cohen EG, Baredes S, Zuckier LS, Mirani NM, Liu Y and Ghesani NV: 18F-FDG PET evaluation of sinonasal papilloma. AJR Am J Roentgenol. 193:214–217. 2009. View Article : Google Scholar : PubMed/NCBI
3	Jeon TY, Kim HJ, Choi JY, et al: 18F-FDG PET/CT findings of sinonasal inverted papilloma with or without coexistent malignancy: Comparison with MR imaging findings in eight patients. Neuroradiology. 51:265–271. 2009. View Article : Google Scholar : PubMed/NCBI
4	Shojaku H, Fujisaka M, Yasumura S, et al: Positron emission tomography for predicting malignancy of sinonasal inverted papilloma. Clin Nucl Med. 32:275–278. 2007. View Article : Google Scholar : PubMed/NCBI
5	Turner JH and Reh DD: Incidence and survival in patients with sinonasal cancer: A historical analysis of population-based data. Head Neck. 34:877–885. 2012. View Article : Google Scholar : PubMed/NCBI
6	Zhao K, Luo XM, Zhou SH, et al: ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography as an effective diagnostic workup in cervical metastasis of carcinoma from an unknown primary tumor. Cancer Biother Radiopharm. 27:685–693. 2012. View Article : Google Scholar : PubMed/NCBI
7	Park JS, Yim JJ, Kang WJ, et al: Detection of primary sites in unknown primary tumors using FDG-PET or FDG-PET/CT. BMC Res Notes. 4:562011. View Article : Google Scholar : PubMed/NCBI
8	Allegra E, Lombardo N, Cascini G, La Boria A, Garozzo A and Tamburrini O: Possible role of 18FDG-PET/CT for the surveillance of sinonasal inverted papilloma. Clin Otolaryngol. 35:249–251. 2010. View Article : Google Scholar : PubMed/NCBI
9	Lee KW, Kuo WR, Tsai CC, Chen YW, Chai CY, Su YC and Lin CS: Positive positron emission tomography/computed tomography in early inverted papilloma of the maxillary sinus. J Clin Oncol. 25:4848–4850. 2007. View Article : Google Scholar : PubMed/NCBI
10	Mathew P and Idiculla JJ: Malignant sinonasal papilloma with neck metastasis: a rare report and literature review. Int J Oral Maxillofac Surg. 41:368–370. 2012. View Article : Google Scholar : PubMed/NCBI
11	Mazlina S, Shiraz MA, Hazim MY, Amran AR, Zulkarnaen AN and Wan Muhaizan WM: Sinonasal inverted papilloma with malignant transformation in the middle ear: a multicentric origin? J Laryngol Otol. 120:597–599. 2006. View Article : Google Scholar : PubMed/NCBI
12	Karam SD, Jay AK, Anyanwu C, Steehler MK, Davidson B, Debrito P and Harter KW: Pathologic collision of inverted papilloma with esthesioneuroblastoma. Front Oncol. 4:442014. View Article : Google Scholar : PubMed/NCBI
13	Barnes L, Vervin RS and Gnepp DR: Diseases of the nose, paranasal sinuses, and nasopharynxSurgical Pathology of the Head and Neck. Barnes L: 1. Marcel Dekker; New York, NY: pp. 403–451. 1985

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Inability of PET/CT to identify a primary sinonasal inverted papilloma with squamous cell carcinoma in a patient with a submandibular lymph node metastasis: A case report

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