Similar survival benefits of a good response and stable disease to platinum-based chemotherapy in non-small cell lung cancer

  • Authors:
    • Tomohiro Tamura
    • Koichi Kurishima
    • Kensuke Nakazawa
    • Hiroichi Ishikawa
    • Hiroaki Satoh
    • Nobuyuki Hizawa
  • View Affiliations

  • Published online on: June 10, 2015     https://doi.org/10.3892/ol.2015.3350
  • Pages: 1135-1140
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Abstract

The present study aimed to evaluate the similar survival benefits of a good response [complete response or partial response (CR/PR)] and stable disease (SD) to chemotherapy in non‑small cell lung cancer (NSCLC) patients in clinical practice. All 322 patients who were treated between 1999 and 2012 with first‑line platinum‑based chemotherapy were retrospectively analyzed. Tumor responses were classified according to the response evaluation criteria for solid tumors. A total of 67 (20.8%) patients experienced CR/PR and 165 (51.2%) achieved SD. There was no difference in progression‑free survival between the patients with CR/PR and those with SD (P=0.347). There was also no difference between the two groups with regard to overall survival time (P=0.878). In multivariate analysis, disease‑control (more than SD) was one of the favorable prognostic factors. In clinical practice, a survival benefit would be provided not only for the patients who have good response, but also for those with SD.
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August-2015
Volume 10 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Tamura T, Kurishima K, Nakazawa K, Ishikawa H, Satoh H and Hizawa N: Similar survival benefits of a good response and stable disease to platinum-based chemotherapy in non-small cell lung cancer. Oncol Lett 10: 1135-1140, 2015
APA
Tamura, T., Kurishima, K., Nakazawa, K., Ishikawa, H., Satoh, H., & Hizawa, N. (2015). Similar survival benefits of a good response and stable disease to platinum-based chemotherapy in non-small cell lung cancer. Oncology Letters, 10, 1135-1140. https://doi.org/10.3892/ol.2015.3350
MLA
Tamura, T., Kurishima, K., Nakazawa, K., Ishikawa, H., Satoh, H., Hizawa, N."Similar survival benefits of a good response and stable disease to platinum-based chemotherapy in non-small cell lung cancer". Oncology Letters 10.2 (2015): 1135-1140.
Chicago
Tamura, T., Kurishima, K., Nakazawa, K., Ishikawa, H., Satoh, H., Hizawa, N."Similar survival benefits of a good response and stable disease to platinum-based chemotherapy in non-small cell lung cancer". Oncology Letters 10, no. 2 (2015): 1135-1140. https://doi.org/10.3892/ol.2015.3350