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Article

Cyclin G2: A novel independent prognostic marker in pancreatic cancer

  • Authors:
    • Shinichiro Hasegawa
    • Hiroaki Nagano
    • Masamitsu Konno
    • Hidetoshi Eguchi
    • Akira Tomokuni
    • Yoshito Tomimaru
    • Hiroshi Wada
    • Naoki Hama
    • Koichi Kawamoto
    • Shogo Kobayashi
    • Shigeru Marubashi
    • Naohiro Nishida
    • Jun Koseki
    • Noriko Gotoh
    • Shouichi Ohno
    • Norikazu Yabuta
    • Hiroshi Nojima
    • Masaki Mori
    • Yuichiro Doki
    • Hideshi Ishii
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka 565‑0871, Japan, Department of Frontier Science for Cancer and Chemotherapy, Osaka University Graduate School of Medicine, Osaka 565‑0871, Japan, Department of Cancer Profiling Discovery, Osaka University Graduate School of Medicine, Osaka 565‑0871, Japan, Division of Cancer Cell Biology, Cancer Research Institute of Kanazawa University, Kanazawa 920‑1192, Japan, Department of Molecular Genetics, Research Institute for Microbial Diseases, Osaka University, Osaka 565‑0871, Japan
  • Pages: 2986-2990
    |
    Published online on: September 2, 2015
       https://doi.org/10.3892/ol.2015.3667
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Abstract

Unlike other cyclins that positively regulate the cell cycle, cyclin G2 (CCNG2) regulates cell proliferation as a tumor suppressor gene. A decreased CCNG2 expression serves as a marker for poor prognosis in several types of cancer. The aim of the present study was to clarify the correlation of CCNG2 expression with overall survival and histopathological factors in pancreatic cancer patients. This retrospective analysis included data from 36 consecutive patients who underwent complete surgical resection for pancreatic cancer and did not undergo any preoperative therapies. The association between prognoses and the expression of CCNG2 was assessed using immunohistochemical staining. Multivariate analysis identified that the expression of CCNG2 is an independent prognostic factor. In addition, the Kaplan‑Meier curve for overall survival revealed that decreased expression of CCNG2 was a consistent indicator of poor prognosis in pancreatic cancer patients (P=0.0198). A decreased CCNG2 expression significantly correlated with venous invasion in tumor specimens and the tumor invasion depth. In conclusion, CCNG2 expression inversely reflected cancer progression and may be a novel, independent prognostic marker in pancreatic cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Hasegawa S, Nagano H, Konno M, Eguchi H, Tomokuni A, Tomimaru Y, Wada H, Hama N, Kawamoto K, Kobayashi S, Kobayashi S, et al: Cyclin G2: A novel independent prognostic marker in pancreatic cancer. Oncol Lett 10: 2986-2990, 2015.
APA
Hasegawa, S., Nagano, H., Konno, M., Eguchi, H., Tomokuni, A., Tomimaru, Y. ... Ishii, H. (2015). Cyclin G2: A novel independent prognostic marker in pancreatic cancer. Oncology Letters, 10, 2986-2990. https://doi.org/10.3892/ol.2015.3667
MLA
Hasegawa, S., Nagano, H., Konno, M., Eguchi, H., Tomokuni, A., Tomimaru, Y., Wada, H., Hama, N., Kawamoto, K., Kobayashi, S., Marubashi, S., Nishida, N., Koseki, J., Gotoh, N., Ohno, S., Yabuta, N., Nojima, H., Mori, M., Doki, Y., Ishii, H."Cyclin G2: A novel independent prognostic marker in pancreatic cancer". Oncology Letters 10.5 (2015): 2986-2990.
Chicago
Hasegawa, S., Nagano, H., Konno, M., Eguchi, H., Tomokuni, A., Tomimaru, Y., Wada, H., Hama, N., Kawamoto, K., Kobayashi, S., Marubashi, S., Nishida, N., Koseki, J., Gotoh, N., Ohno, S., Yabuta, N., Nojima, H., Mori, M., Doki, Y., Ishii, H."Cyclin G2: A novel independent prognostic marker in pancreatic cancer". Oncology Letters 10, no. 5 (2015): 2986-2990. https://doi.org/10.3892/ol.2015.3667
Copy and paste a formatted citation
x
Spandidos Publications style
Hasegawa S, Nagano H, Konno M, Eguchi H, Tomokuni A, Tomimaru Y, Wada H, Hama N, Kawamoto K, Kobayashi S, Kobayashi S, et al: Cyclin G2: A novel independent prognostic marker in pancreatic cancer. Oncol Lett 10: 2986-2990, 2015.
APA
Hasegawa, S., Nagano, H., Konno, M., Eguchi, H., Tomokuni, A., Tomimaru, Y. ... Ishii, H. (2015). Cyclin G2: A novel independent prognostic marker in pancreatic cancer. Oncology Letters, 10, 2986-2990. https://doi.org/10.3892/ol.2015.3667
MLA
Hasegawa, S., Nagano, H., Konno, M., Eguchi, H., Tomokuni, A., Tomimaru, Y., Wada, H., Hama, N., Kawamoto, K., Kobayashi, S., Marubashi, S., Nishida, N., Koseki, J., Gotoh, N., Ohno, S., Yabuta, N., Nojima, H., Mori, M., Doki, Y., Ishii, H."Cyclin G2: A novel independent prognostic marker in pancreatic cancer". Oncology Letters 10.5 (2015): 2986-2990.
Chicago
Hasegawa, S., Nagano, H., Konno, M., Eguchi, H., Tomokuni, A., Tomimaru, Y., Wada, H., Hama, N., Kawamoto, K., Kobayashi, S., Marubashi, S., Nishida, N., Koseki, J., Gotoh, N., Ohno, S., Yabuta, N., Nojima, H., Mori, M., Doki, Y., Ishii, H."Cyclin G2: A novel independent prognostic marker in pancreatic cancer". Oncology Letters 10, no. 5 (2015): 2986-2990. https://doi.org/10.3892/ol.2015.3667
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