Large cell neuroendocrine cervical tumor treated by radical surgery and adjuvant chemotherapy: A case report and literature review

Bacalbașa,Nicolae; Stoica,Claudia; Marcu,Madalina; Mihalache,Daniela; Vasilescu,Florina; Popa,Ileana; Mirea,Gratiela; Bălescu,Irina

doi:10.3892/ol.2015.3878

January-2016 Volume 11 Issue 1

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January-2016 Volume 11 Issue 1

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Case Report Open Access

Large cell neuroendocrine cervical tumor treated by radical surgery and adjuvant chemotherapy: A case report and literature review

Authors:
- Nicolae Bacalbașa
- Claudia Stoica
- Madalina Marcu
- Daniela Mihalache
- Florina Vasilescu
- Ileana Popa
- Gratiela Mirea
- Irina Bălescu
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Affiliations: Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, Bucharest 050474, Romania, Department of General Surgery, Ilfov County Hospital, Bucharest 13118, Romania, Department of Anatomopathology, Cytopath Laboratory, Braila 810249, Romania, Department of Anatomopathology, GreenOnco Medical, Bucharest 010903, Romania, Department of General Surgery, Ponderas Hospital, Bucharest 014412, Romania

Copyright: © Bacalbașa et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 189-193
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Published online on: November 6, 2015

https://doi.org/10.3892/ol.2015.3878
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Abstract

Neuroendocrine carcinomas of the uterine cervix are rare, but extremely aggressive, gynecological malignancies that are associated with an overall poor prognosis. The present study reports the case of a 41‑year‑old patient diagnosed with large cell neuroendocrine cervical tumor. A radical total hysterectomy with bilateral adnexectomy, pelvic and lymph node dissection was performed. The post‑operative course was uneventful, and the patient was discharged on post‑operative day 8.

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1	Klimstra DS, Modlin IR, Coppola D, Lloyd RV and Suster S: The pathologic classification of neuroendocrine tumors: A review of nomenclature, grading, and staging systems. Pancreas. 39:707–712. 2010. View Article : Google Scholar : PubMed/NCBI
2	Albores-Saavedra J, Larraza O, Poucell S and Rodriguez Martinez HA: Carcinoid of the uterine cervix: Additional observations on a new tumor entity. Cancer. 38:2328–2342. 1976. View Article : Google Scholar : PubMed/NCBI
3	Albores-Saavedra J, Gersell D, Gilks CB, Henson DE, Lindberg G, Santiago H, Scully RE, Silva E, Sobin LH, Tavassoli FJ, et al: Terminology of endocrine tumors of the uterine cervix: Results of a workshop sponsored by the College of American Pathologists and the National Cancer Institute. Arch Pathol Lab Med. 121:34–39. 1997.PubMed/NCBI
4	Reagan JW, Hamonic MJ and Wentz WB: Analytical study of the cells in cervical squamous-cell cancer. Lab Invest. 6:241–250. 1957.PubMed/NCBI
5	Stoler MH, Mills SE, Gersell DJ and Walker AN: Small-cell neuroendocrine carcinoma of the cervix. A human papillomavirus type 18-associated cancer. Am J Surg Pathol. 15:28–32. 1991. View Article : Google Scholar : PubMed/NCBI
6	Hirahatake K, Hareyama H, Kure R, Kawaguchi I, Yamaguchi J, Sakuragi N and Fujimoto S: Cytologic and hormonal findings in a carcinoid tumor of the uterine cervix. Acta Cytol. 34:119–124. 1990.PubMed/NCBI
7	Sato Y, Shimamoto T, Amada S, Asada Y and Hayashi T: Large cell neuroendocrine carcinoma of the uterine cervix: A clinicopathological study of six cases. Int J Gynecol Pathol. 22:226–230. 2003. View Article : Google Scholar : PubMed/NCBI
8	Wang KL, Wang TY, Huang YC, Lai JC, Chang TC and Yen MS: Human papillomavirus type and clinical manifestation in seven cases of large-cell neuroendocrine cervical carcinoma. J Formos Med Assoc. 108:428–432. 2009. View Article : Google Scholar : PubMed/NCBI
9	Strosberg JR, Coppola D, Klimstra DS, Phan AT, Kulke MH, Wiseman GA and Kvols LK: North American Neuroendocrine Tumor Society (NANETS): The NANETS consensus guidelines for the diagnosis and management of poorly differentiated (high-grade) extrapulmonary neuroendocrine carcinomas. Pancreas. 39:799–800. 2010. View Article : Google Scholar : PubMed/NCBI
10	Chen J, Macdonald OK and Gaffney DK: Incidence, mortality, and prognostic factors of small cell carcinoma of the cervix. Obstet Gynecol. 111:1394–1402. 2008. View Article : Google Scholar : PubMed/NCBI
11	McCusker ME, Coté TR, Clegg LX and Tavassoli FJ: Endocrine tumors of the uterine cervix: Incidence, demographics, and survival with comparison to squamous cell carcinoma. Gynecol Oncol. 88:333–339. 2003. View Article : Google Scholar : PubMed/NCBI
12	Gaspar LE, Gay EG, Crawford J, Putnam JB, Herbst RS and Bonner JA: Limited-stage small-cell lung cancer (stages I–III): Observations from the National Cancer Data Base. Clin Lung Cancer. 6:355–360. 2005. View Article : Google Scholar : PubMed/NCBI
13	Rekhi B, Patil B, Deodhar KK, Maheshwari AA, Kerkar R, Gupta S, Tongaonkar HB and Shrivastava SK: Spectrum of neuroendocrine carcinomas of the uterine cervix, including histopathologic features, terminology, immunohistochemical profile, and clinical outcomes in a series of 50 cases from a single institution in India. Ann Diagn Pathol. 17:1–9. 2013. View Article : Google Scholar : PubMed/NCBI
14	Gilks CB, Young RH, Gersell DJ and Clement PB: Large cell neuroendocrine [corrected] carcinoma of the uterine cervix: A clinicopathologic study of 12 cases. Am J Surg Pathol. 21:905–914. 1997. View Article : Google Scholar : PubMed/NCBI
15	Embry JR, Kelly MG, Post MD and Spillman MA: Large cell neuroendocrine carcinoma of the cervix: Prognostic factors and survival advantage with platinum chemotherapy. Gynecol Oncol. 120:444–448. 2011. View Article : Google Scholar : PubMed/NCBI
16	Boruta DM II, Schorge JO, Duska LA, Crum CP, Castrillon DH and Sheets EE: Multimodality therapy in early-stage neuroendocrine carcinoma of the uterine cervix. Gynecol Oncol. 81:82–87. 2001. View Article : Google Scholar : PubMed/NCBI
17	Kasamatsu T, Sasajima Y, Onda T, Sawada M, Kato T and Tanikawa M: Surgical treatment for neuroendocrine carcinoma of the uterine cervix. Int J Gynaecol Obstet. 99:225–228. 2007. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Large cell neuroendocrine cervical tumor treated by radical surgery and adjuvant chemotherapy: A case report and literature review

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Abstract

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