Intercellular adhesion molecule 1 is a sensitive and diagnostically useful immunohistochemical marker of papillary thyroid cancer (PTC) and of PTC‑like nuclear alterations in Hashimoto's thyroiditis

Zhang,Ke; Ge,Shu‑Jian; Lin,Xiao‑Yan; Lv,Bei‑Bei; Cao,Zhi‑Xin; Li,Jia‑Mei; Xu,Jia‑Wen; Wang,Qiang‑Xiu

doi:10.3892/ol.2016.4104

March-2016 Volume 11 Issue 3

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March-2016 Volume 11 Issue 3

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Article Open Access

Intercellular adhesion molecule 1 is a sensitive and diagnostically useful immunohistochemical marker of papillary thyroid cancer (PTC) and of PTC‑like nuclear alterations in Hashimoto's thyroiditis

Authors:
- Ke Zhang
- Shu‑Jian Ge
- Xiao‑Yan Lin
- Bei‑Bei Lv
- Zhi‑Xin Cao
- Jia‑Mei Li
- Jia‑Wen Xu
- Qiang‑Xiu Wang
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Affiliations: Department of Nuclear Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China, Department of Science and Education, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China, Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China

Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 1722-1730
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Published online on: January 14, 2016

https://doi.org/10.3892/ol.2016.4104
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Abstract

Intercellular adhesion molecule 1 (ICAM‑1) is important in the progression of inflammatory responses. Recently, increased levels of ICAM‑1 have been reported in a number of types of malignancy. The present study aimed to investigate ICAM‑1 expression in papillary thyroid cancer (PTC) and in Hashimoto's thyroiditis (HT) with PTC‑like nuclear alterations, and to assess the predictive value of ICAM‑1 in thyroid lesions. ICAM‑1 expression was retrospectively investigated in 132 consecutive cases of PTC, 72 cases of HT, 10 of follicular cancer, 15 of follicular adenoma, 16 of nodular goiter and 8 samples of normal thyroid tissue using immunohistochemical analyses, and in 42 PTC patients using western blotting. ICAM‑1 expression was not detected in normal follicular cells, follicular lesions (adenoma and cancer) and benign nodular hyperplasia, but was frequently overexpressed in PTC cells. ICAM‑1 overexpression was associated with extra‑thyroidal invasion and lymph node metastasis; no association was found with age, gender, tumor size, multifocality, pathological stage, recurrence or distant metastasis. ICAM‑1 expression in HT patients with PTC‑like nuclear alterations was significantly higher than that in HT cases with non‑PTC‑like features. Compared with antibodies against cytokeratin 19, galectin‑3 and Hector Battifora mesothelial‑1, ICAM‑1 was the most sensitive marker for the detection of PTC‑like features in HT. These findings demonstrate that ICAM‑1 expression is upregulated in PTC and in HT with PTC‑like nuclear alterations. This feature may be an important factor in the progression of cancer of the thyroid gland.

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