Open Access

Clinical significance of midkine expression in sporadic desmoid tumors

  • Authors:
    • Hee Sung Kim
    • Jin Kim
    • Kyung Han Nam
    • Woo Ho Kim
  • View Affiliations

  • Published online on: January 19, 2016     https://doi.org/10.3892/ol.2016.4129
  • Pages: 1677-1684
  • Copyright: © Kim et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The aim of the present study was to identify the prognostic factors for the propensity for recurrence in sporadic desmoid tumors. The catenin (cadherin‑associated protein) β1 (CTNNB1) genotypes and expression of Wnt pathway proteins and midkine (also termed neurite growth‑promoting factor 2) were investigated in 159 patients with sporadic desmoid tumors. Formalin‑fixed paraffin‑embedded tissues of the surgically resected desmoid tumors were examined by direct sequencing of CTNNB1 exon 3, and immunostained for the expression of β‑catenin, T‑cell factor 4 (TCF‑4), phosphorylated protein kinase B (pAkt), midkine and menin using a tissue microarray method. Among the samples, 70% (111/159) exhibited point mutations of the CTNNB1 gene, including T41A (56%), S45F (8%), S45P (2%), S45N (2%) and T42A (1%). In addition, 100, 57, 24, 15 and 92% of the tumors expressed β‑catenin, TCF‑4, midkine, pAkt and menin, respectively. Positive midkine expression was significantly associated with the recurrence of tumors (P=0.001). The multivariate analysis of recurrence demonstrated that an extra‑abdominal tumor site [hazard ratio (HR), 2.625; P=0.001] and midkine expression (HR, 2.077; P<0.009) were independent prognostic factors of tumor recurrence. In conclusion, the present results suggest that the tumor site and midkine expression may be predictive markers for the recurrence of sporadic desmoid tumors.
View Figures
View References

Related Articles

Journal Cover

March-2016
Volume 11 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Kim HS, Kim J, Nam KH and Kim WH: Clinical significance of midkine expression in sporadic desmoid tumors. Oncol Lett 11: 1677-1684, 2016
APA
Kim, H.S., Kim, J., Nam, K.H., & Kim, W.H. (2016). Clinical significance of midkine expression in sporadic desmoid tumors. Oncology Letters, 11, 1677-1684. https://doi.org/10.3892/ol.2016.4129
MLA
Kim, H. S., Kim, J., Nam, K. H., Kim, W. H."Clinical significance of midkine expression in sporadic desmoid tumors". Oncology Letters 11.3 (2016): 1677-1684.
Chicago
Kim, H. S., Kim, J., Nam, K. H., Kim, W. H."Clinical significance of midkine expression in sporadic desmoid tumors". Oncology Letters 11, no. 3 (2016): 1677-1684. https://doi.org/10.3892/ol.2016.4129