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Article Open Access

Clinical significance of midkine expression in sporadic desmoid tumors

  • Authors:
    • Hee Sung Kim
    • Jin Kim
    • Kyung Han Nam
    • Woo Ho Kim
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, College of Medicine, Chung‑Ang University, Seoul 156‑755, Republic of Korea, Cancer Research Institute, College of Medicine, Seoul National University, Seoul 110‑799, Republic of Korea, Department of Pathology, Haeundae Paik Hospital, Inje University College of Medicine, Busan 612‑896, Republic of Korea
    Copyright: © Kim et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1677-1684
    |
    Published online on: January 19, 2016
       https://doi.org/10.3892/ol.2016.4129
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Abstract

The aim of the present study was to identify the prognostic factors for the propensity for recurrence in sporadic desmoid tumors. The catenin (cadherin‑associated protein) β1 (CTNNB1) genotypes and expression of Wnt pathway proteins and midkine (also termed neurite growth‑promoting factor 2) were investigated in 159 patients with sporadic desmoid tumors. Formalin‑fixed paraffin‑embedded tissues of the surgically resected desmoid tumors were examined by direct sequencing of CTNNB1 exon 3, and immunostained for the expression of β‑catenin, T‑cell factor 4 (TCF‑4), phosphorylated protein kinase B (pAkt), midkine and menin using a tissue microarray method. Among the samples, 70% (111/159) exhibited point mutations of the CTNNB1 gene, including T41A (56%), S45F (8%), S45P (2%), S45N (2%) and T42A (1%). In addition, 100, 57, 24, 15 and 92% of the tumors expressed β‑catenin, TCF‑4, midkine, pAkt and menin, respectively. Positive midkine expression was significantly associated with the recurrence of tumors (P=0.001). The multivariate analysis of recurrence demonstrated that an extra‑abdominal tumor site [hazard ratio (HR), 2.625; P=0.001] and midkine expression (HR, 2.077; P<0.009) were independent prognostic factors of tumor recurrence. In conclusion, the present results suggest that the tumor site and midkine expression may be predictive markers for the recurrence of sporadic desmoid tumors.
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1 

Reitamo JJ, Häyry P, Nykyri E and Saxén E: The desmoid tumor. I. Incidence, sex-, age- and anatomical distribution in the Finnish population. Am J Clin Pathol. 77:665–673. 1982.PubMed/NCBI

2 

Alman BA, Li C, Pajerski ME, Diaz-Cano S and Wolfe HJ: Increased beta-catenin protein and somatic APC mutations in sporadic aggressive fibromatoses (desmoid tumors). Am J Pathol. 151:329–334. 1997.PubMed/NCBI

3 

Colombo C, Creighton CJ, Ghadimi MP, Bolshakov S, Warneke CL, Zhang Y, Lusby K, Zhu S, Lazar AJ, West RB, et al: Increased midkine expression correlates with desmoid tumour recurrence: A potential biomarker and therapeutic target. J Pathol. 225:574–582. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Fiore M, Rimareix F, Mariani L, Domont J, Collini P, Le Péchoux C, Casali PG, Le Cesne A, Gronchi A and Bonvalot S: Desmoid-type fibromatosis: A front-line conservative approach to select patients for surgical treatment. Ann Surg Oncol. 16:2587–2593. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Ballo MT, Zagars GK, Pollack A, Pisters PW and Pollack RA: Desmoid tumor: Prognostic factors and outcome after surgery, radiation therapy, or combined surgery and radiation therapy. J Clin Oncol. 17:158–167. 1999.PubMed/NCBI

6 

Lazar AJ, Tuvin D, Hajibashi S, Habeeb S, Bolshakov S, Mayordomo-Aranda E, Warneke CL, Lopez-Terrada D, Pollock RE and Lev D: Specific mutations in the beta-catenin gene (CTNNB1) correlate with local recurrence in sporadic desmoid tumors. Am J Pathol. 173:1518–1527. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Lazar AJ, Hajibashi S and Lev D: Desmoid tumor: From surgical extirpation to molecular dissection. Curr Opin Oncol. 21:352–359. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Colombo C, Miceli R, Lazar AJ, Perrone F, Pollock RE, Le Cesne A, Hartgrink HH, Cleton-Jansen AM, Domont J, Bovée JV, et al: CTNNB1 45F mutation is a molecular prognosticator of increased postoperative primary desmoid tumor recurrence: An independent, multicenter validation study. Cancer. 119:3696–3702. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Sakamoto K and Kadomatsu K: Midkine in the pathology of cancer, neural disease, and inflammation. Pathol Int. 62:445–455. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Cao Y, Liu R, Jiang X, Lu J, Jiang J, Zhang C, Li X and Ning G: Nuclear-cytoplasmic shuttling of menin regulates nuclear translocation of {beta}-catenin. Mol Cell Biol. 29:5477–5487. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Weiss SW and Goldblum JR: Fibromatoses. Enzinger and Weiss's Soft Tissue Tumors. 1:(5th). (Philadelphia, PA). Elsevier, Inc. 2282008.

12 

Meng K, Rodriguez-Peña A, Dimitrov T, Chen W, Yamin M, Noda M and Deuel TF: Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta. Proc Natl Acad Sci USA. 97:2603–2608. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Nik Amini S, Hohenstein P, Jadidizadeh A, Van Dam K, Bastidas A, Berry RL, Patek CE, Van der Schueren B, Cassiman JJ and Tejpar S: Upregulation of Wilms' tumor gene 1 (WT1) in desmoid tumors. Int J Cancer. 114:202–208. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Adachi Y, Matsubara S, Pedraza C, Ozawa M, Tsutsui J, Takamatsu H, Noguchi H, Akiyama T and Muramatsu T: Midkine as a novel target gene for the Wilms' tumor suppressor gene (WT1). Oncogene. 13:2197–2203. 1996.PubMed/NCBI

15 

Mignemi NA, Itani DM, Fasig JH, Keedy VL, Hande KR, Whited BW, Homlar KC, Correa H, Coffin CM, Black JO, et al: Signal transduction pathway analysis in desmoid-type fibromatosis: Transforming growth factor-β, COX2 and sex steroid receptors. Cancer Sci. 103:2173–2180. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Cheon S, Poon R, Yu C, Khoury M, Shenker R, Fish J and Alman BA: Prolonged beta-catenin stabilization and tcf-dependent transcriptional activation in hyperplastic cutaneous wounds. Lab Invest. 85:416–425. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Amary MF, Pauwels P, Meulemans E, Roemen GM, Islam L, Idowu B, Bousdras K, Diss TC, O'Donnell P and Flanagan AM: Detection of beta-catenin mutations in paraffin-embedded sporadic desmoid-type fibromatosis by mutation-specific restriction enzyme digestion (MSRED): An ancillary diagnostic tool. Am J Surg Pathol. 31:1299–1309. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Dômont J, Salas S, Lacroix L, Brouste V, Saulnier P, Terrier P, Ranchère D, Neuville A, Leroux A, Guillou L, et al: High frequency of β-catenin heterozygous mutations in extra-abdominal fibromatosis: A potential molecular tool for disease management. Br J Cancer. 102:1032–1036. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Huss S, Nehles J, Binot E, Wardelmann E, Mittler J, Kleine MA, Künstlinger H, Hartmann W, Hohenberger P, Merkelbach-Bruse S, et al: β-catenin (CTNNB1) mutations and clinicopathological features of mesenteric desmoid-type fibromatosis. Histopathology. 62:294–304. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Saito T, Oda Y, Tanaka K, Matsuda S, Tamiya S, Iwamoto Y and Tsuneyoshi M: Beta-catenin nuclear expression correlates with cyclin D1 overexpression in sporadic desmoid tumours. J Pathol. 195:222–228. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Tejpar S, Nollet F, Li C, Wunder JS, Michils G, dal Cin P, Van Cutsem E, Bapat B, van Roy F, Cassiman JJ and Alman BA: Predominance of beta-catenin mutations and beta-catenin dysregulation in sporadic aggressive fibromatosis (desmoid tumor). Oncogene. 18:6615–6620. 1999. View Article : Google Scholar : PubMed/NCBI

22 

Coffin CM, Hornick JL, Zhou H and Fletcher CD: Gardner fibroma: A clinicopathologic and immunohistochemical analysis of 45 patients with 57 fibromas. Am J Surg Pathol. 31:410–416. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Montgomery E and Folpe AL: The diagnostic value of beta-catenin immunohistochemistry. Adv Anat Pathol. 12:350–356. 2005. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kim HS, Kim J, Nam KH and Kim WH: Clinical significance of midkine expression in sporadic desmoid tumors. Oncol Lett 11: 1677-1684, 2016.
APA
Kim, H.S., Kim, J., Nam, K.H., & Kim, W.H. (2016). Clinical significance of midkine expression in sporadic desmoid tumors. Oncology Letters, 11, 1677-1684. https://doi.org/10.3892/ol.2016.4129
MLA
Kim, H. S., Kim, J., Nam, K. H., Kim, W. H."Clinical significance of midkine expression in sporadic desmoid tumors". Oncology Letters 11.3 (2016): 1677-1684.
Chicago
Kim, H. S., Kim, J., Nam, K. H., Kim, W. H."Clinical significance of midkine expression in sporadic desmoid tumors". Oncology Letters 11, no. 3 (2016): 1677-1684. https://doi.org/10.3892/ol.2016.4129
Copy and paste a formatted citation
x
Spandidos Publications style
Kim HS, Kim J, Nam KH and Kim WH: Clinical significance of midkine expression in sporadic desmoid tumors. Oncol Lett 11: 1677-1684, 2016.
APA
Kim, H.S., Kim, J., Nam, K.H., & Kim, W.H. (2016). Clinical significance of midkine expression in sporadic desmoid tumors. Oncology Letters, 11, 1677-1684. https://doi.org/10.3892/ol.2016.4129
MLA
Kim, H. S., Kim, J., Nam, K. H., Kim, W. H."Clinical significance of midkine expression in sporadic desmoid tumors". Oncology Letters 11.3 (2016): 1677-1684.
Chicago
Kim, H. S., Kim, J., Nam, K. H., Kim, W. H."Clinical significance of midkine expression in sporadic desmoid tumors". Oncology Letters 11, no. 3 (2016): 1677-1684. https://doi.org/10.3892/ol.2016.4129
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