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Article

S100A8/A9 is associated with estrogen receptor loss in breast cancer

  • Authors:
    • Yi Bao
    • Antao Wang
    • Juanfen Mo
  • View Affiliations / Copyright

    Affiliations: Basic and Translational Cancer Research Laboratory, The Second Hospital of Jiaxing, Jiaxing, Zhejiang 314000, P.R. China
  • Pages: 1936-1942
    |
    Published online on: January 20, 2016
       https://doi.org/10.3892/ol.2016.4134
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Abstract

S100A8 and S100A9 are calcium‑binding proteins that are secreted primarily by granulocytes and monocytes, and are upregulated during the inflammatory response. S100A8 and S100A9 have been identified to be expressed by epithelial cells involved in malignancy. In the present study, the transcriptional levels of S100A8 and S100A9 were investigated in various subtypes of breast cancer (BC), and the correlation with estrogen receptor 1 (ESR1) and GATA binding protein 3 (GATA3) gene expression was evaluated using microarray datasets. The expression of S100A8 and S100A9 in BC cells was assessed by reverse transcription‑polymerase chain reaction (RT‑PCR). The regulation of ESR1 and GATA3 by administration of recombinant S100A8/A9 was examined in the BC MCF‑7 cell line using quantitative (q)PCR. The association between S100A8 and S100A9 and overall survival (OS) was investigated in GeneChip® data of BC. The expression levels of S100A8 and S100A9 were higher in human epidermal growth factor receptor 2 (Her2)‑amplified and basal‑like BC. The messenger (m)RNA levels of S100A8 and S100A9 were inversely correlated with ESR1 and GATA3 expression. S100A8/A9 induced a 10‑fold decrease in the mRNA levels of ESR1 in MCF‑7 cells. Poor OS was associated with high expression levels of S100A9, but not with high expression levels of S100A8 in BC. In conclusion, strong expression and secretion of S100A8/A9 may be associated with the loss of estrogen receptor in BC, and may be involved in the poor prognosis of Her2+/basal‑like subtypes of BC.
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Copy and paste a formatted citation
Spandidos Publications style
Bao Y, Wang A and Mo J: S100A8/A9 is associated with estrogen receptor loss in breast cancer. Oncol Lett 11: 1936-1942, 2016.
APA
Bao, Y., Wang, A., & Mo, J. (2016). S100A8/A9 is associated with estrogen receptor loss in breast cancer. Oncology Letters, 11, 1936-1942. https://doi.org/10.3892/ol.2016.4134
MLA
Bao, Y., Wang, A., Mo, J."S100A8/A9 is associated with estrogen receptor loss in breast cancer". Oncology Letters 11.3 (2016): 1936-1942.
Chicago
Bao, Y., Wang, A., Mo, J."S100A8/A9 is associated with estrogen receptor loss in breast cancer". Oncology Letters 11, no. 3 (2016): 1936-1942. https://doi.org/10.3892/ol.2016.4134
Copy and paste a formatted citation
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Spandidos Publications style
Bao Y, Wang A and Mo J: S100A8/A9 is associated with estrogen receptor loss in breast cancer. Oncol Lett 11: 1936-1942, 2016.
APA
Bao, Y., Wang, A., & Mo, J. (2016). S100A8/A9 is associated with estrogen receptor loss in breast cancer. Oncology Letters, 11, 1936-1942. https://doi.org/10.3892/ol.2016.4134
MLA
Bao, Y., Wang, A., Mo, J."S100A8/A9 is associated with estrogen receptor loss in breast cancer". Oncology Letters 11.3 (2016): 1936-1942.
Chicago
Bao, Y., Wang, A., Mo, J."S100A8/A9 is associated with estrogen receptor loss in breast cancer". Oncology Letters 11, no. 3 (2016): 1936-1942. https://doi.org/10.3892/ol.2016.4134
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