Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
March-2016 Volume 11 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2016 Volume 11 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Analysis of the expression of SDF-1 splicing variants in human colorectal cancer and normal mucosa tissues

  • Authors:
    • Risala Hussain Allami
    • Claudine Graf
    • Ksenia Martchenko
    • Beatrice Voss
    • Marc Becker
    • Martin R. Berger
    • Peter R. Galle
    • Matthias Theobald
    • Thomas C. Wehler
    • Carl C. Schimanski
  • View Affiliations / Copyright

    Affiliations: First Department of Internal Medicine, Johannes Gutenberg University Hospital of Mainz, D‑55130 Mainz, Germany, Third Department of Internal Medicine, Johannes Gutenberg University Hospital of Mainz, D‑55130 Mainz, Germany, Department of Internal Medicine, Marienhospital Darmstadt, D‑64285 Darmstadt, Germany, Research Group Toxicology and Chemotherapy, German Cancer Research Center, D‑69117 Heidelberg, Germany
  • Pages: 1873-1878
    |
    Published online on: January 25, 2016
       https://doi.org/10.3892/ol.2016.4139
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

C-X-C motif chemokine ligand 12 (CXCL12), also termed stromal cell-derived factor-1 (SDF-1) is a small protein 8‑14 kDa in length that is expressed as six isoforms, consisting of SDF‑1α, SDF‑1β, SDF‑1γ, SDF‑1δ, SDF‑1ε and SDF‑1θ. All six isoforms are encoded by the single CXCL12 gene on chromosome 10. This gene regulates leukocyte trafficking and is variably expressed in a number of normal and cancer tissues. The potential role of the novel CXCL12 splice variants as components of the CXCR4 axis in cancer development is not fully understood. The present study aimed to analyze the expression profile of the various SDF‑1 isoforms and SDF‑1 polymorphisms, and the association with the clinicopathological features and overall survival of patients with colorectal cancer (CRC). SDF‑1 polymorphism analysis was performed using restriction fragment length polymorphism (RFLP) analysis in 73 histologically confirmed human CRC tissue samples at various stages of disease. The expression pattern of the SDF‑1 isoforms was analyzed by reverse transcription‑polymerase chain reaction in 40 histologically confirmed human CRC tissue samples obtained at various stages of disease, as well as in matched adjacent normal mucosa samples. The presence of the CXCL12 gene polymorphism rs1801157 demonstrated an association with local progression of the primary tumor, as indicated by the T stage. The frequency of the GG genotype was slightly increased in patients with stage 3 and 4 tumors (78.0%) compared with the incidence of the GA/AA genotype (69.5%; P=0.067). The expression of SDF‑1β was associated with the presence of metastases (P=0.0656) and the expression of SDF‑1γ was significantly associated with tumor size (P=0.0423). The present study is the first to analyze the association between the expression profile of the chemokine CXCL12 splice variants in human CRC tissues and their clinical relevance. The present results reveal that the CXCL12 G801A polymorphism is a low‑penetrance risk factor for the development of CRC, and was associated with the T stage. All six isoforms of SDF‑1 were expressed in CRC tissues. The expression of SDF‑1β was found to be associated with metastases and SDF‑1γ appears to be a possible tumor marker for local tumor progression.
View Figures

Figure 1

Figure 2

View References

1 

Greenlee RT, Murray T, Bolden S and Wingo PA: Cancer statistics, 2000. CA Cancer J Clin. 50:7–33. 2000. View Article : Google Scholar : PubMed/NCBI

2 

Weir HK, Thun MJ, Hankey BF, Ries LA, Howe HL, Wingo PA, Jemal A, Ward E, Anderson RN and Edwards BK: Annual report to the nation on the status of cancer, 1975–2000, featuring the uses of surveillance data for cancer prevention and control. J Natl Cancer Inst. 95:1276–1299. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Zlotnik A: Chemokines and cancer. Int J Cancer. 119:2026–2029. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Premack BA and Schall TJ: Chemokine receptors: gateways to inflammation and infection. Nat Med. 2:1174–1178. 1996. View Article : Google Scholar : PubMed/NCBI

5 

Bagglioni M: Chemokines and leukocyte traffic. Nature. 392:565–568. 1998. View Article : Google Scholar : PubMed/NCBI

6 

Bleul CC, Schultze JL and Spinger TA: B lymphocyte chemotaxis regulated in association with microanatomic localization, differentiation state and B cell receptor engagement. J Exp Med. 187:753–762. 1998. View Article : Google Scholar : PubMed/NCBI

7 

Schimanski CC, Schwald S, Simiantonaki N, Javasinghe C, et al: Effect of chemokine receptors CXCR4 and CCR7 on the metastatic behavior of human colorectal cancer. Clin Cancer Res. 11:1743–1750. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Hao L, Zhang C, Wang L, Luo Y, et al: Recombination of CXCR4, VEGF and MMP-9 predicting lymph node metastasis in human breast cancer. Cancer Lett. 253:34–42. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Shanmugam MK, Manu KA, Ong TH, Ramachandran L, Surana R, Bist P, Lim LH, Kumar AP, Hui KM and Sethi G: Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model. Int J Cancer. 129:1552–1563. 2011. View Article : Google Scholar : PubMed/NCBI

10 

D'Alterio C, Barbieri A, Portella L, Palma G, Polimeno M, Riccio A, Ieranò C, Franco R, Scognamiglio G, Bryce J, et al: Inhibition of stromal CXCR4 impairs development of lung metastases. Cancer Immunol Immunother. 61:1713–1720. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Liang Z, Yoon Y, Votaw J, Goodman MM, Williams L and Shim H: Silencing of CXCR4 blocks breast cancer metastasis. Cancer Res. 65:967–971. 2005.PubMed/NCBI

12 

Smith MC, Luker KE, Garbow JR, Prior JL, Jackson E, Piwnica-Worms D and Luker GD: CXCR4 regulates growth of both primary and metastatic breast cancer. Cancer Res. 64:8604–8612. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Phillips RJ, Burdick MD, Lutz M, Belperio JA, Keane MP and Strieter RM: The stromal derived factor-1/CXCL12-CXC chemokine receptor 4 biological axis in non-small cell lung cancer metastases. Am J Respir Crit Care Med. 167:1676–1686. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Sun XS, Wei L, Chen Q and Terek RM: CXCR4/SDF1 mediate hypoxia induced chondrosarcoma cell invasion through ERK signaling and increased MMP1 expression. Mol Cancer. 9:172010. View Article : Google Scholar : PubMed/NCBI

15 

Pan J, Mestas J, Burdick MD, Phillips RJ, Thomas GV, Reckamp K, Belperio JA and Strieter RM: Stromal derived factor-I (SDF-I/CXCL12) and CXCR4 in renal cell carcinoma metastasis. Mol Cancer. 5:562006. View Article : Google Scholar : PubMed/NCBI

16 

Kollmar O, Rupertus K, Scheuer C, Junker B, et al: Stromal cell-derived factor-1 promotes cell migration and tumor growth of colorectal metastasis. Neoplasia. 9:862–870. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Mori T, Doi R, Koizumi M, Toyoda E, et al: CXCR4 antagonist inhibits stromal cell-derived factor-1-induced migration and invasion of human pancreatic cancer. Mol Cancer Ther. 3:29–37. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Yu L, Cecil J, Peng SB, Schrementi J, et al: Identification and expression of novel isoforms of human stromal cell-derived factor 1. Gene. 374:174–179. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Janowski M: Functional diversity of SDF-1 splicing variants. Cell Adh Migr. 3:243–249. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Lombardi L, Tavano F, Morelli F, Latiano TP, Di Sebastiano P and Maiello E: Chemokine receptor CXCR4: Role in gastrointestinal cancer. Crit Rev Oncol Hematol. 88:696–705. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Chada S, Ramesh R and Mhashilkar AM: Cytokine- and chemokine-based gene therapy for cancer. Curr Opin Mol Ther. 5:463–474. 2003.PubMed/NCBI

22 

Dimberg J, Hugander A, Löfgren S and Wagsater D: Polymorphism and circulating levels of the chemokine CXCL12 in colorectal cancer patients. Int J Mol Med. 19:11–15. 2007.PubMed/NCBI

23 

Allami RH: Influence of the chemokine CXCL12 on the progression and the signalling in colorectal cancer. PhD dissertation. Der Johannes Gutenberg-Universität. (ArchiMed, Mainz). 2013.

24 

Manetti M, Liakouli V, Fatini C, Cipriani P, Bonino C, Vettori S, Guiducci S, Montecucco C, Abbate R, Valentini G, Matucci-Cerinic M, Giacomelli R and Ibba-Manneschi L: Association between a stromal cell derived factor1 (SDF-1/cxcl12) gene polymorphism and microvascular disease in systemic sclerosis. Ann Rheum Dis. 68:408–411. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Liu W, Zhu E, Wang R, Wang L and Liu T: CXCL12 G801A polymorphism is associated with an increased risk of benign salivary gland tumors in the Chinese population. Med Oncol. 29:677–681. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Yu L, Cecil J, Peng SB, Schrementi J, Kovacevic S, Paul D, Su EW and Wang J: Identification and expression of novel isoforms of human stromal cell-derived factor 1. Gene. 374:174–179. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Winkler C, Modi W, Smith MW, Nelson GW, Wu X, Carrington M, Dean M, Honjo T, Tashiro K, Yabe D, Buchbinder S, Vittinghoff E, Goedert JJ, O'Brien TR, Jacobson LP, Detels R, Donfield S, Willoughby A, Gomperts E, Vlahov D, Phair J and O'Brien SJ: Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant variant. ALIVE Study, Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS). San Francisco City Cohort (SFCC) Science. 279:389–393. 1998.

28 

Razmkhah M, Doroudchi M, Ghayumi SM, Erfani N and Ghaderi A: Stromal cell-derived factor-1 (SDF-1) gene and susceptibility of Iranian patients with lung cancer. Lung Cancer. 49:311–315. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Razmkhah M, Talei AR, Doroudchi M, Khalili-Azad T and Ghaderi A: Stromal cell-derived factor-1 (SDF-1) alleles and susceptibility to breast carcinoma. Cancer Lett. 225:261–266. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Dommange F, Cartron G, Espanel C, Gallay N, Domenech J, Benboubker L, Ohresser M, Colombat P, Binet C, Watier H and Herault O: GOELAMS Study Group: CXCL12 polymorphism and malignant cell dissemination/tissue infiltration in acute myeloid leukemia. Faseb J. 20:1913–1915. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Hirata H, Hinoda Y, Kikuno N, Kawamoto K, Dahiya AV, Suehiro Y, Tanaka Y and Dahiya R: CXCL12 G801A polymorphism is a risk factor for sporadic prostate cancer susceptibility. Clin Cancer Res. 13:5056–5062. 2007. View Article : Google Scholar : PubMed/NCBI

32 

de Oliveira KB, Oda JM, Voltarelli JC, Nasser TF, Ono MA, Fujita TC, Matsuo T and Watanabe MA: CXCL12 rs1801157 polymorphism in patients with breast cancer, Hodgkin's lymphoma and non-Hodgkin's lymphoma. J Clin Lab Anal. 23:387–393. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Teng YH, Liu TH, Tseng HC, Chung TT, Yeh CM, Li YC, Ou YH, Lin LY, Tsai HT and Yang SF: Contribution of genetic polymorphisms of stromal cell-derived factor-1 and its receptor, CXCR4, to the susceptibility and clinicopathologic development of oral cancer. Head Neck. 31:1282–1288. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Vairaktaris E, Vylliotis A, Spyridonodou S, Derka S, Vassiliou S, Nkenke E, Yapijakis C, Serefoglou Z, Neukam FW and Patsouris E: A DNA polymorphism of stromal-derived factor-1 is associated with advanced stages of oral cancer. Anticancer Res. 28:271–275. 2008.PubMed/NCBI

35 

Zhu K, Jiang B, Hu R, Yang Y, Miao M, Li Y and Liu Z: The CXCL12 G801A polymorphism is associated with cancer risk: A meta-analysis. PLoS One. 9:e1089532014. View Article : Google Scholar : PubMed/NCBI

36 

Hidalgo-Pascual M, Galan JJ, Chaves-Conde M, Ramírez-Armengol JA, Moreno C, Calvo E, Pelaez P, Crespo C, Ruiz A and Royo JL: Analysis of CXCL12 3′UTR G>A polymorphism in colorectal cancer. Oncol Rep. 18:1583–1587. 2007.PubMed/NCBI

37 

Chang SC, Lin PC, Yang SH, Wang HS, Li AF and Lin JK: SDF-1alpha G801A polymorphism predicts lymph node metastasis in stage T3 colorectal cancer. Ann Surg Oncol. 16:2323–2330. 2009. View Article : Google Scholar : PubMed/NCBI

38 

Gong H, Tan M, Wang Y, Shen B, Liu Z, Zhang F, Liu Y, Qiu J, Bao E and Fan Y: The CXCL12 G801A polymorphism and cancer risk: evidence from 17 case-control studies. Gene. 509:228–231. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Altenburg JD, Broxmeyer HE, Jin Q, Cooper S, Basu S and Alkhatib G: A naturally occurring splice variant of CXCL12/stromal cell-derived factor 1 is a potent human immunodeficiency virus type 1 inhibitor with weak chemotaxis and cell survival activities. J Virol. 81:8140–8148. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Janowski M: Functional diversity of SDF-1 splicing variants. Cell Adh Migr. 3:243–249. 2009. View Article : Google Scholar : PubMed/NCBI

41 

Sun X, Cheng G, Hao M, Zheng J, Zhou X, Zhang J, Taichman RS, Pienta KJ and Wang J: CXCL12/CXCR4/CXCR7 chemokine axis and cancer progression. Cancer Metastasis Rev. 29:709–722. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Colobran R, Pujol-Borrell R, Armengol MP and Juan M: The chemokine network II. On how polymorphisms and alternative splicing increase the number of molecular species and configure intricate patterns of disease susceptibility. Clin Exp Immunol. 150:1–12. 2007. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Allami RH, Graf C, Martchenko K, Voss B, Becker M, Berger MR, Galle PR, Theobald M, Wehler TC, Schimanski CC, Schimanski CC, et al: Analysis of the expression of SDF-1 splicing variants in human colorectal cancer and normal mucosa tissues. Oncol Lett 11: 1873-1878, 2016.
APA
Allami, R.H., Graf, C., Martchenko, K., Voss, B., Becker, M., Berger, M.R. ... Schimanski, C.C. (2016). Analysis of the expression of SDF-1 splicing variants in human colorectal cancer and normal mucosa tissues. Oncology Letters, 11, 1873-1878. https://doi.org/10.3892/ol.2016.4139
MLA
Allami, R. H., Graf, C., Martchenko, K., Voss, B., Becker, M., Berger, M. R., Galle, P. R., Theobald, M., Wehler, T. C., Schimanski, C. C."Analysis of the expression of SDF-1 splicing variants in human colorectal cancer and normal mucosa tissues". Oncology Letters 11.3 (2016): 1873-1878.
Chicago
Allami, R. H., Graf, C., Martchenko, K., Voss, B., Becker, M., Berger, M. R., Galle, P. R., Theobald, M., Wehler, T. C., Schimanski, C. C."Analysis of the expression of SDF-1 splicing variants in human colorectal cancer and normal mucosa tissues". Oncology Letters 11, no. 3 (2016): 1873-1878. https://doi.org/10.3892/ol.2016.4139
Copy and paste a formatted citation
x
Spandidos Publications style
Allami RH, Graf C, Martchenko K, Voss B, Becker M, Berger MR, Galle PR, Theobald M, Wehler TC, Schimanski CC, Schimanski CC, et al: Analysis of the expression of SDF-1 splicing variants in human colorectal cancer and normal mucosa tissues. Oncol Lett 11: 1873-1878, 2016.
APA
Allami, R.H., Graf, C., Martchenko, K., Voss, B., Becker, M., Berger, M.R. ... Schimanski, C.C. (2016). Analysis of the expression of SDF-1 splicing variants in human colorectal cancer and normal mucosa tissues. Oncology Letters, 11, 1873-1878. https://doi.org/10.3892/ol.2016.4139
MLA
Allami, R. H., Graf, C., Martchenko, K., Voss, B., Becker, M., Berger, M. R., Galle, P. R., Theobald, M., Wehler, T. C., Schimanski, C. C."Analysis of the expression of SDF-1 splicing variants in human colorectal cancer and normal mucosa tissues". Oncology Letters 11.3 (2016): 1873-1878.
Chicago
Allami, R. H., Graf, C., Martchenko, K., Voss, B., Becker, M., Berger, M. R., Galle, P. R., Theobald, M., Wehler, T. C., Schimanski, C. C."Analysis of the expression of SDF-1 splicing variants in human colorectal cancer and normal mucosa tissues". Oncology Letters 11, no. 3 (2016): 1873-1878. https://doi.org/10.3892/ol.2016.4139
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team