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Association between ALDH1+/CD133+ stem-like cells and tumor angiogenesis in invasive ductal breast carcinoma

  • Authors:
    • Xinquan Lv
    • Yingzi Wang
    • Yimin Song
    • Xia Pang
    • Huixiang Li
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China, Department of Nephropathy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
    Copyright: © Lv et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1750-1756
    |
    Published online on: January 26, 2016
       https://doi.org/10.3892/ol.2016.4145
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Abstract

The growth and metastasis of tumors is dependent on angiogenesis; however, the association between tumor stem cells (TSCs) and tumor angiogenesis remains to be elucidated. The present study aimed to investigate the expression of the TSC markers aldehyde dehydrogenase 1 (ALDH1) and cluster of differentiation 133 (CD133) in invasive ductal breast carcinoma, and identify their correlation with tumor angiogenesis. Stem‑like cells from the breast tissue of 120 patients, who were diagnosed with invasive ductal breast carcinoma at The First Affiliated Hospital of Zhengzhou University (Zhengzhou, Henan, China) between January 2009 and December 2010, were collected by surgical resection and analyzed using immunohistochemical double staining. The expression of the vascular markers CD34, CD105 and vascular endothelial growth factor (VEGF) were determined using single staining. Overall, 25.83% (31/120) of the specimens contained a large number of ALDH1+/CD133+ stem‑like cells (ALDH1+/CD133+ tumor). ALDH1+/CD133+ expression is associated with microvessel density, VEGF‑positive rate and estrogen receptor expression (P<0.05); however, ALDH1+/CD133+ expression was not associated with age, tumor diameter, lymph node metastasis, histological classification, progesterone receptor expression or human epidermal growth factor receptor 2 expression (P>0.05). The ALDH1+/CD133+ tumor phenotype and expression of VEGF were identified to be correlated in the present study (P=0.020). The present study revealed a close association between breast cancer TSC markers, including ALDH1 and CD133, and tumor angiogenesis. The results of the present study may provide a novel target and treatment strategy for future studies investigating tumor growth and metastasis.
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Copy and paste a formatted citation
Spandidos Publications style
Lv X, Wang Y, Song Y, Pang X and Li H: Association between ALDH1+/CD133+ stem-like cells and tumor angiogenesis in invasive ductal breast carcinoma. Oncol Lett 11: 1750-1756, 2016.
APA
Lv, X., Wang, Y., Song, Y., Pang, X., & Li, H. (2016). Association between ALDH1+/CD133+ stem-like cells and tumor angiogenesis in invasive ductal breast carcinoma. Oncology Letters, 11, 1750-1756. https://doi.org/10.3892/ol.2016.4145
MLA
Lv, X., Wang, Y., Song, Y., Pang, X., Li, H."Association between ALDH1+/CD133+ stem-like cells and tumor angiogenesis in invasive ductal breast carcinoma". Oncology Letters 11.3 (2016): 1750-1756.
Chicago
Lv, X., Wang, Y., Song, Y., Pang, X., Li, H."Association between ALDH1+/CD133+ stem-like cells and tumor angiogenesis in invasive ductal breast carcinoma". Oncology Letters 11, no. 3 (2016): 1750-1756. https://doi.org/10.3892/ol.2016.4145
Copy and paste a formatted citation
x
Spandidos Publications style
Lv X, Wang Y, Song Y, Pang X and Li H: Association between ALDH1+/CD133+ stem-like cells and tumor angiogenesis in invasive ductal breast carcinoma. Oncol Lett 11: 1750-1756, 2016.
APA
Lv, X., Wang, Y., Song, Y., Pang, X., & Li, H. (2016). Association between ALDH1+/CD133+ stem-like cells and tumor angiogenesis in invasive ductal breast carcinoma. Oncology Letters, 11, 1750-1756. https://doi.org/10.3892/ol.2016.4145
MLA
Lv, X., Wang, Y., Song, Y., Pang, X., Li, H."Association between ALDH1+/CD133+ stem-like cells and tumor angiogenesis in invasive ductal breast carcinoma". Oncology Letters 11.3 (2016): 1750-1756.
Chicago
Lv, X., Wang, Y., Song, Y., Pang, X., Li, H."Association between ALDH1+/CD133+ stem-like cells and tumor angiogenesis in invasive ductal breast carcinoma". Oncology Letters 11, no. 3 (2016): 1750-1756. https://doi.org/10.3892/ol.2016.4145
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