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Article

A retrospective review of 11 cases of villoglandular papillary adenocarcinoma of the uterine cervix and a review of the literature

  • Authors:
    • Liping Zhao
    • Tianmin Xu
    • Manhua Cui
    • Zeming Fu
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology and Obstetrics, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China
  • Pages: 2164-2168
    |
    Published online on: February 1, 2016
       https://doi.org/10.3892/ol.2016.4172
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Abstract

Villoglandular papillary adenocarcinoma (VGPA) of the uterine cervix is a rare subtype of cervical adenocarcinoma (AC) that accounts for 3.7‑4.8% of cervical AC. Compared with ordinary adenocarcinoma, VGPA is associated with a lower incidence, younger age and better prognosis. Treatment with fertility‑preserving surgery is also possible. The present study analyzed cases treated in The Second Hospital of Jilin University (Changchun, Jilin, China) between January 2010 and December 2014. A total of 11 cases were selected; of these, 7 cases were pathologically confirmed. The remaining 4 cases were diagnosed as VGPA upon the pathological examination of the biopsy, but confirmed as another type of adenocarcinoma upon analysis of the surgical pathology. The median age of the patients whose pathology was confirmed post‑operatively was 36 years, and all cases were positive for human papillomavirus (HPV). As all 7 patients had no requirement for further fertility, a radical hysterectomy was performed, with or without adjuvant therapy. The follow‑up time ranged from 7‑57 months, with a mean time of 29 months. There was no evidence of recurrence in any of the patients. All the patients remain alive to date. The results of the present study indicated that HPV infection is likely to be the cause of VGPA, and the prognosis of VGPA tends to be better compared with other types of adenocarcinoma. However, the number of studies that have reported cases of VGPA remains small, and all are retrospective analyses with short follow-up times. Therefore, physicians selecting treatment options for patients with VGPA should exercise caution.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao L, Xu T, Cui M and Fu Z: A retrospective review of 11 cases of villoglandular papillary adenocarcinoma of the uterine cervix and a review of the literature. Oncol Lett 11: 2164-2168, 2016.
APA
Zhao, L., Xu, T., Cui, M., & Fu, Z. (2016). A retrospective review of 11 cases of villoglandular papillary adenocarcinoma of the uterine cervix and a review of the literature. Oncology Letters, 11, 2164-2168. https://doi.org/10.3892/ol.2016.4172
MLA
Zhao, L., Xu, T., Cui, M., Fu, Z."A retrospective review of 11 cases of villoglandular papillary adenocarcinoma of the uterine cervix and a review of the literature". Oncology Letters 11.3 (2016): 2164-2168.
Chicago
Zhao, L., Xu, T., Cui, M., Fu, Z."A retrospective review of 11 cases of villoglandular papillary adenocarcinoma of the uterine cervix and a review of the literature". Oncology Letters 11, no. 3 (2016): 2164-2168. https://doi.org/10.3892/ol.2016.4172
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao L, Xu T, Cui M and Fu Z: A retrospective review of 11 cases of villoglandular papillary adenocarcinoma of the uterine cervix and a review of the literature. Oncol Lett 11: 2164-2168, 2016.
APA
Zhao, L., Xu, T., Cui, M., & Fu, Z. (2016). A retrospective review of 11 cases of villoglandular papillary adenocarcinoma of the uterine cervix and a review of the literature. Oncology Letters, 11, 2164-2168. https://doi.org/10.3892/ol.2016.4172
MLA
Zhao, L., Xu, T., Cui, M., Fu, Z."A retrospective review of 11 cases of villoglandular papillary adenocarcinoma of the uterine cervix and a review of the literature". Oncology Letters 11.3 (2016): 2164-2168.
Chicago
Zhao, L., Xu, T., Cui, M., Fu, Z."A retrospective review of 11 cases of villoglandular papillary adenocarcinoma of the uterine cervix and a review of the literature". Oncology Letters 11, no. 3 (2016): 2164-2168. https://doi.org/10.3892/ol.2016.4172
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