Small bowel adenocarcinoma arising in a patient with hereditary hemorrhagic telangiectasia: A case report

Yoshioka,Yuichiro; Nozawa,Hiroaki; Tanaka,Junichiro; Nishikawa,Takeshi; Tanaka,Toshiaki; Kiyomatsu,Tomomichi; Kawai,Kazushige; Hata,Keisuke; Kazama,Shinsuke; Yamaguchi,Hironori; Ishihara,Soichiro; Sunami,Eiji; Kitayama,Joji; Watanabe,Toshiaki

doi:10.3892/ol.2016.4173

March-2016 Volume 11 Issue 3

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March-2016 Volume 11 Issue 3

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Case Report

Small bowel adenocarcinoma arising in a patient with hereditary hemorrhagic telangiectasia: A case report

Authors:
- Yuichiro Yoshioka
- Hiroaki Nozawa
- Junichiro Tanaka
- Takeshi Nishikawa
- Toshiaki Tanaka
- Tomomichi Kiyomatsu
- Kazushige Kawai
- Keisuke Hata
- Shinsuke Kazama
- Hironori Yamaguchi
- Soichiro Ishihara
- Eiji Sunami
- Joji Kitayama
- Toshiaki Watanabe
View Affiliations / Copyright

Affiliations: Department of Surgical Oncology, University of Tokyo, Tokyo 113‑8655, Japan
Pages: 2137-2139
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Published online on: February 1, 2016

https://doi.org/10.3892/ol.2016.4173
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Abstract

Patients with hereditary hemorrhagic telangiectasia (HHT) are reportedly at a lower overall risk of malignancies, and small bowel adenocarcinoma (SBA) arising in a HHT patient is extremely rare. In this study, the case of a 37‑year‑old female with HHT who developed a poorly differentiated jejunal adenocarcinoma five years after ileocecal resection for multiple colonic adenomas is presented. The patient underwent curative resection of the cancer invading the ileum and the mesentery of the transverse colon, but had to overcome critical complications perioperatively, stemming from HHT-associated peripheral capillary dilatation and arteriovenous malformation, including nosebleeds and possible infusion-induced air embolism through pulmonary shunts. The patient subsequently received adjuvant chemotherapy including capecitabine and oxaliplatin for 6 months, and currently remains alive without any evidence of recurrence 12 months after the second surgery. This patient with SBA was an instructive case demonstrating the necessity of careful attention during major surgery in HHT.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Small bowel adenocarcinoma arising in a patient with hereditary hemorrhagic telangiectasia: A case report

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