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Article

Elevated matrix metalloproteinase‑9 expression may contribute to the pathogenesis of bladder cancer

  • Authors:
    • Fan‑Chang Zeng
    • Song Cen
    • Zheng‑Yan Tang
    • Xin‑Li Kang
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China, Department of Urology, People's Hospital of Hainan Province, Haikou, Hainan 570311, P.R. China
  • Pages: 2213-2222
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    Published online on: February 4, 2016
       https://doi.org/10.3892/ol.2016.4187
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Abstract

The present study investigated the potential association between matrix metalloproteinase‑9 (MMP‑9) expression and the pathogenesis of bladder cancer. The present study reviewed previous studies published in Chinese and English using predefined selection criteria, which identified high‑quality studies concerning MMP‑9 and bladder cancer. Statistical analyses of the data were conducted using Comprehensive Meta‑Analysis software version 2.0. In total, 23 case‑control studies were selected, which consisted of 1,040 bladder cancer patients and 244 healthy controls. The expression rates and protein levels of MMP‑9 were significantly increased in bladder cancer patients compared with the healthy controls, which was demonstrated using immunohistochemistry (IHC) and enzyme‑linked immunosorbent assay‑based methods. Furthermore, the expression rate of MMP‑9 in histological G1/G2 grade bladder cancer tumors was significantly decreased compared with G3 tumors. Subgroup analysis based on ethnicity demonstrated that the rate of MMP‑9 protein expression between bladder cancer patients and healthy controls was significantly different in African, Asian and Caucasian patients, which was identified using IHC. The MMP‑9 protein levels in bladder cancer patients and healthy controls were significantly different between Asian and Caucasian patients, but not African patients. The differences between MMP‑9 expression in ethnic groups were also evident in the expression rate of MMP‑9 identified in histological G1/G2 grade tumors in Asian and Caucasian patients compared with G3 grade tumors, which was not evident in African patients. In conclusion, the present meta‑analysis results markedly indicate that MMP‑9 expression is associated with clinicopathological features of bladder cancer, suggesting that MMP‑9 may be a useful biomarker in the diagnosis and clinical management of bladder cancer, and may be a valuable therapeutic target.
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View References

1 

Burger M, Catto JW, Dalbagni G, Grossman HB, Herr H, Karakiewicz P, Kassouf W, Kiemeney LA, La Vecchia C, Shariat S and Lotan Y: Epidemiology and risk factors of urothelial bladder cancer. Eur Urol. 63:234–241. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Menashe I, Figueroa JD, Garcia-Closas M, Chatterjee N, Malats N, Picornell A, Maeder D, Yang Q, Prokunina-Olsson L, Wang Z, et al: Large-scale pathway-based analysis of bladder cancer genome-wide association data from five studies of European background. PLoS One. 7:e293962012. View Article : Google Scholar : PubMed/NCBI

3 

Kumar B, Koul S, Petersen J, Khandrika L, Hwa JS, Meacham RB, Wilson S and Koul HK: p38 mitogen-activated protein kinase-driven MAPKAPK2 regulates invasion of bladder cancer by modulation of MMP-2 and MMP-9 activity. Cancer Res. 70:832–841. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Gui Y, Guo G, Huang Y, et al: Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder. Nat Genet. 43:875–878. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Samplaski MK, Heston W, Elson P, Magi-Galluzzi C and Hansel DE: Folate hydrolase (prostate-specific membrane [corrected] antigen) 1 expression in bladder cancer subtypes and associated tumor neovasculature. Mod Pathol. 24:1521–1529. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Yan Y, Liang H, Li T, Li M, Li R, Qin X and Li S: The MMP-1, MMP-2, and MMP-9 gene polymorphisms and susceptibility to bladder cancer: A meta-analysis. Tumour Biol. 35:3047–3052. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Said N, Frierson HF, Sanchez-Carbayo M, Brekken RA and Theodorescu D: Loss of SPARC in bladder cancer enhances carcinogenesis and progression. J Clin Invest. 123:751–766. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Zhuo W, Zhang L, Cai L, Zhu B and Chen Z: XRCC1 Arg399Gln polymorphism and bladder cancer risk: Updated meta-analyses based on 5767 cases and 6919 controls. Exp Biol Med (Maywood). 238:66–76. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Offersen BV, Knap MM, Horsman MR, Verheijen J, Hanemaaijer R and Overgaard J: Matrix metalloproteinase-9 measured in urine from bladder cancer patients is an independent prognostic marker of poor survival. Acta Oncol. 49:1283–1287. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Jacobs BL, Lee CT and Montie JE: Bladder cancer in: 2010 How far have we come? CA Cancer J Clin. 60:244–272. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Burger M, Oosterlinck W, Konety B, Chang S, Gudjonsson S, Pruthi R, Soloway M, Solsona E, Sved P, Babjuk M, et al: International Consultation on Urologic Disease-European Association of Urology Consultation on Bladder Cancer: 2012 ICUD EAU International Consultation on Bladder Cancer 2012: Non-muscle-invasive urothelial carcinoma of the bladder. Eur Urol. 63:36–44. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Bauvois B: New facets of matrix metalloproteinases MMP-2 and MMP-9 as cell surface transducers: Outside-in signaling and relationship to tumor progression. Biochim Biophys Acta. 1825:29–36. 2012.PubMed/NCBI

13 

Zitka O, Kukacka J, Krizkova S, Huska D, Adam V, Masarik M, Prusa R and Kizek R: Matrix metalloproteinases. Curr Med Chem. 17:3751–3768. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Surgucheva I, Chidambaram K, Willoughby DA and Surguchov A: Matrix metalloproteinase 9 expression: New regulatory elements. J Ocul Biol Dis Infor. 3:41–52. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Eissa S, Badr S, Elhamid SA, Helmy AS, Nour M and Esmat M: The value of combined use of survivin mRNA and matrix metalloproteinase 2 and 9 for bladder cancer detection in voided urine. Dis Markers. 34:57–62. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Vandooren J, Van den Steen PE and Opdenakker G: Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): The next decade. Crit Rev Biochem Mol Biol. 48:222–272. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Kessenbrock K, Plaks V and Werb Z: Matrix metalloproteinases: Regulators of the tumor microenvironment. Cell. 141:52–67. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Gunes M, Kemik AS, Pirincci N, Gecit I, Taken K, Yuksel MB, Kaba M and Eryilmaz R: Preoperative levels of matrix metalloproteinase-7 and −9 and tissue inhibitor of matrix metalloproteinase-1 relation to pathologic parameters in bladder carcinoma patients. Asian Pac J Cancer Prev. 14:873–876. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Urquidi V, Chang M, Dai Y, Kim J, Wolfson ED, Goodison S and Rosser CJ: IL-8 as a urinary biomarker for the detection of bladder cancer. BMC Urol. 12:122012. View Article : Google Scholar : PubMed/NCBI

20 

Goodison S, Chang M, Dai Y, Urquidi V and Rosser CJ: A multi-analyte assay for the non-invasive detection of bladder cancer. PLoS One. 7:e474692012. View Article : Google Scholar : PubMed/NCBI

21 

Chen H, Manning AK and Dupuis J: A method of moments estimator for random effect multivariate meta-analysis. Biometrics. 68:1278–1284. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Higgins JP and Thompson SG: Quantifying heterogeneity in a meta-analysis. Stat Med. 21:1539–1558. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Jackson D, White IR and Riley RD: Quantifying the impact of between-study heterogeneity in multivariate meta-analyses. Stat Med. 31:3805–3820. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Peters JL, Sutton AJ, Jones DR, Abrams KR and Rushton L: Comparison of two methods to detect publication bias in meta-analysis. JAMA. 295:676–680. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Zintzaras E and Ioannidis JP: Heterogeneity testing in meta-analysis of genome searches. Genet Epidemiol. 28:123–137. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Sterne JA and Egger M: Funnel plots for detecting bias in meta-analysis: Guidelines on choice of axis. J Clin Epidemiol. 54:1046–1055. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Wikstrom EA, Naik S, Lodha N and Cauraugh JH: Balance capabilities after lateral ankle trauma and intervention: A meta-analysis. Med Sci Sports Exerc. 41:1287–1295. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Egger M, Smith Davey G, Schneider M and Minder C: Bias in meta-analysis detected by a simple, graphical test. BMJ. 315:629–634. 1997. View Article : Google Scholar : PubMed/NCBI

29 

Zhao B, Wang Q, Lei Y, Zhang G, Li R and Song Z: Study on the expression of MMP-9 and CD34 in bladder urothelial carcinoma and their correlation. J Clin Res. 31:1518–1521. 2014.(In Chinese).

30 

Bianco FJ Jr, Gervasi DC, Tiguert R, Grignon DJ, Pontes JE, Crissman JD, Fridman R and Wood DP Jr: Matrix metalloproteinase-9 expression in bladder washes from bladder cancer patients predicts pathological stage and grade. Clin Cancer Res. 4:3011–3016. 1998.PubMed/NCBI

31 

Eissa S, Ali-Labib R, Swellam M, Bassiony M, Tash F and El-Zayat TM: Noninvasive diagnosis of bladder cancer by detection of matrix metalloproteinases (MMP-2 and MMP-9) and their inhibitor (TIMP-2) in urine. Eur Urol. 52:1388–1396. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Eissa S, Labib RA, Mourad MS, Kamel K and El-Ahmady O: Comparison of telomerase activity and matrix metalloproteinase-9 in voided urine and bladder wash samples as a useful diagnostic tool for bladder cancer. Eur Urol. 44:687–694. 2003. View Article : Google Scholar : PubMed/NCBI

33 

Zhu F, Zhang Y, Yan R, Zhang HQ and Zhang YJ: Correlation of expressions of MMP-2 and MMP-9 in the transitional cell carcinoma of bladder with tremor invasion and metastasis. Zhong Liu Yan Jiu Yu Lin Chuang. 21:680–682. 2009.(In Chinese).

34 

Zhang FM, Gao XM, Li SS, Li SB, Liu Y and Xu H: Expressions of MMP-9 and VEGF in 65 cases with bladder transitional cell carcinoma and their significance. Zhong Liu Xue Za Zhi. 15:1032–1034. 2009.(In Chinese).

35 

Guan KP, Ye HY, Yan Z, Wang Y and Hou SK: Serum levels of endostatin and matrix metalloproteinase-9 associated with high stage and grade primary transitional cell carcinoma of the bladder. Urology. 61:719–723. 2003. View Article : Google Scholar : PubMed/NCBI

36 

Zhang JF, Sun LJ, Luo B, Hao J, Song BL and Liu P: Expression of survivin, MMP-9 and PTEN proteins in bladder carcinoma. Xian Dai Yu Fang Yi Xue. 37:4681–4682. 2010.(In Chinese).

37 

Guo JH, Wang HR, Wang J, Zhu J and Song HY: Expression of matrix metalloproteinase-9 and its correlation with tumor interstitial microvascular density and tumor metastasis in transitional cell carcinoma of the bladder. Zhong Guo Ai Zheng Za Zhi. 14:116–118. 2004.(In Chinese).

38 

Wang JH, Chen ZF, Chen WB and Shi Z: Expression of MMP-9 and TIMP-1 in bladder cancer and its significance. Xian Dai Mi Niao Wai Ke Za Zhi. 9:140–141. 2004.(In Chinese).

39 

Chen JS, Yang WM, Xu YM and Wang SL: The expression of MMP-9 and cyclin E in bladder urothelial carcinoma and their clinical significance. Xian Dai Mi Niao Wai Ke Za Zhi. 26:726–731. 2011.(In Chinese).

40 

Nutt JE, Durkan GC, Mellon JK and Lunec J: Matrix metalloproteinases (MMPs) in bladder cancer: The induction of MMP9 by epidermal growth factor and its detection in urine. BJU Int. 91:99–104. 2003. View Article : Google Scholar : PubMed/NCBI

41 

de Ramón Fata F, Ferruelo A, Andrés G, Gimbernat H, Sánchez-Chapado M and Angulo JC: The role of matrix metalloproteinase MMP-9 and TIMP-2 tissue inhibitor of metalloproteinases as serum markers of bladder cancer. Actas Urol Esp. 37:480–488. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Zheng XY, Pang X, Wang FJ and Zhu ZQ: Expression of CXCR4 and MMP-9 in bladder transitional cell carcinoma tissue. Xian Dai Sheng Wu Yi. 12:5255–5260. 2012.(In Chinese).

43 

Wu Y and Zeng FQ: Expression of MMP-9/TIMP-1 in bladder and the clinical significance transitional cell carcinoma. Xian Dai Mi Niao Wai Ke Za Zhi. 20:577–580. 2005.(In Chinese).

44 

Sun YX, Zhang ZC, Sun LQ and Gao HW: Correlation of content and expression of matrix metalloproteinases in transitional cell carcinoma of bladder with tumor invasion and metastasis. Ji Lin Da Xue Xue Bao (Yi Xue Ban). 31:127–129. 2005.(In Chinese).

45 

Tang ZH, Guo SX, Cai QF and Chen TL: Expressions of MMP-9 and TIMP-1 and their relationship with the invasion and metastasis of bladder cancer. Guo Ji Mi Niao Xi Tong Za Zhi. 27:148–152. 2007.(In Chinese).

46 

Zhong A, Yang WM and Ye ZQ: The expression of urinary MMP2 and MMP9 in the bladder transitional cell carcinoma and their correlations to the tumor invasion and metastasis. Chuang Wai Ke Za Zhi. 14:655–657. 2006.(In Chinese).

47 

Zhu ZQ, Zheng XY, Zhu QH, Wen JH and Fan CH: Expression and clinical significance of CXCR4 and MMP-9 in bladder cancer. Zhong Guo Xian Dai Yi Xue Za Zhi. 19:337–340. 2009.(In Chinese), 343.

48 

Lu P, Takai K, Weaver VM and Werb Z: Extracellular matrix degradation and remodeling in development and disease. Cold Spring Harb Perspect Biol. 3:a0050582011. View Article : Google Scholar : PubMed/NCBI

49 

Jacob-Ferreira AL, Lacchini R, Gerlach RF, Passos CJ, Barbosa F Jr and Tanus-Santos JE: A common matrix metalloproteinase (MMP)-2 polymorphism affects plasma MMP-2 levels in subjects environmentally exposed to mercury. Sci Total Environ. 409:4242–4246. 2011. View Article : Google Scholar : PubMed/NCBI

50 

Castro MM, Rizzi E, Rodrigues GJ, Ceron CS, Bendhack LM, Gerlach RF and Tanus-Santos JE: Antioxidant treatment reduces matrix metalloproteinase-2-induced vascular changes in renovascular hypertension. Free Radic Biol Med. 46:1298–1307. 2009. View Article : Google Scholar : PubMed/NCBI

51 

Ceron CS, Castro MM, Rizzi E, Montenegro MF, Fontana V, Salgado MC, Gerlach RF and Tanus-Santos JE: Spironolactone and hydrochlorothiazide exert antioxidant effects and reduce vascular matrix metalloproteinase-2 activity and expression in a model of renovascular hypertension. Br J Pharmacol. 160:77–87. 2010. View Article : Google Scholar : PubMed/NCBI

52 

O-Charoenrat P and Khantapura P: The role of genetic polymorphisms in the promoters of the matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 genes in head and neck cancer. Oral Oncol. 42:257–267. 2006. View Article : Google Scholar : PubMed/NCBI

53 

Gialeli C, Theocharis AD and Karamanos NK: Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting. FEBS J. 278:16–27. 2011. View Article : Google Scholar : PubMed/NCBI

54 

Srivastava P, Mandhani A, Kapoor R and Mittal RD: Role of MMP-3 and MMP-9 and their haplotypes in risk of bladder cancer in North Indian cohort. Ann Surg Oncol. 17:3068–3075. 2010. View Article : Google Scholar : PubMed/NCBI

55 

Sand JM, Larsen L, Hogaboam C, Martinez F, Han M, Larsen Røssel M, Nawrocki A, Zheng Q, Karsdal MA and Leeming DJ: MMP mediated degradation of type IV collagen alpha 1 and alpha 3 chains reflects basement membrane remodeling in experimental and clinical fibrosis - validation of two novel biomarker assays. PLoS One. 8:e849342013. View Article : Google Scholar : PubMed/NCBI

56 

Reis ST, Leite KR, Piovesan LF, Pontes-Junior J, Viana NI, Abe DK, Crippa A, Moura CM, Adonias SP, Srougi M and Dall'Oglio MF: Increased expression of MMP-9 and IL-8 are correlated with poor prognosis of Bladder Cancer. BMC Urol. 12:182012. View Article : Google Scholar : PubMed/NCBI

57 

Kumar B, Koul S, Petersen J, Khandrika L, Hwa JS, Meacham RB, Wilson S and Koul HK: p38 mitogen-activated protein kinase-driven MAPKAPK2 regulates invasion of bladder cancer by modulation of MMP-2 and MMP-9 activity. Cancer Res. 70:832–841. 2010. View Article : Google Scholar : PubMed/NCBI

58 

Stankovic S, Konjevic G, Gopcevic K, Jovic V, Inic M and Jurisic V: Activity of MMP-2 and MMP-9 in sera of breast cancer patients. Pathol Res Pract. 206:241–247. 2010. View Article : Google Scholar : PubMed/NCBI

59 

Zamilpa R, Ramirez TA, Dai Q, Dayah T, Nguyen N, Zhang J, Ahuja SS, D'Armiento, Jin YF and Lindsey ML: MMP-9 overexpression in macrophages regulates the post-myocardial infarction inflammatory response through SCYE1. FASEB J. 26(Suppl): 399.22012.

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Copy and paste a formatted citation
Spandidos Publications style
Zeng FC, Cen S, Tang ZY and Kang XL: Elevated matrix metalloproteinase‑9 expression may contribute to the pathogenesis of bladder cancer. Oncol Lett 11: 2213-2222, 2016.
APA
Zeng, F., Cen, S., Tang, Z., & Kang, X. (2016). Elevated matrix metalloproteinase‑9 expression may contribute to the pathogenesis of bladder cancer. Oncology Letters, 11, 2213-2222. https://doi.org/10.3892/ol.2016.4187
MLA
Zeng, F., Cen, S., Tang, Z., Kang, X."Elevated matrix metalloproteinase‑9 expression may contribute to the pathogenesis of bladder cancer". Oncology Letters 11.3 (2016): 2213-2222.
Chicago
Zeng, F., Cen, S., Tang, Z., Kang, X."Elevated matrix metalloproteinase‑9 expression may contribute to the pathogenesis of bladder cancer". Oncology Letters 11, no. 3 (2016): 2213-2222. https://doi.org/10.3892/ol.2016.4187
Copy and paste a formatted citation
x
Spandidos Publications style
Zeng FC, Cen S, Tang ZY and Kang XL: Elevated matrix metalloproteinase‑9 expression may contribute to the pathogenesis of bladder cancer. Oncol Lett 11: 2213-2222, 2016.
APA
Zeng, F., Cen, S., Tang, Z., & Kang, X. (2016). Elevated matrix metalloproteinase‑9 expression may contribute to the pathogenesis of bladder cancer. Oncology Letters, 11, 2213-2222. https://doi.org/10.3892/ol.2016.4187
MLA
Zeng, F., Cen, S., Tang, Z., Kang, X."Elevated matrix metalloproteinase‑9 expression may contribute to the pathogenesis of bladder cancer". Oncology Letters 11.3 (2016): 2213-2222.
Chicago
Zeng, F., Cen, S., Tang, Z., Kang, X."Elevated matrix metalloproteinase‑9 expression may contribute to the pathogenesis of bladder cancer". Oncology Letters 11, no. 3 (2016): 2213-2222. https://doi.org/10.3892/ol.2016.4187
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