Open Access

Giant and high-risk gastrointestinal stromal tumor in the abdomino-pelvic cavity: A case report

  • Authors:
    • Yujiao Wang
    • Jie Peng
    • Jinbai Huang
  • View Affiliations

  • Published online on: February 8, 2016     https://doi.org/10.3892/ol.2016.4196
  • Pages: 2035-2038
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gastrointestinal stromal tumors (GISTs) are benign mesenchymal tumors of the gastrointestinal tract. The clinical presentations of patients with GIST are variable and may be non‑specific. The current study reports the case of a 66-year-old man that presented with a gradual enlargement of the abdomen, emaciation, hyperhidrosis and frequent and urgent micturition. A computed tomography (CT) scan of the abdomen revealed a large, heterogeneous, low density mass that occupied the entire abdomino-pelvic cavity. Magnetic resonance imaging (MRI) identified a high signal intensity on the T2 weighted image and an intermediate signal intensity on the T1 weighted image. A contrast enhanced CT scan and MRI demonstrated the uptake of contrast material. A biopsy revealed that the tumor was composed of spindle cells, and immunohistochemical analysis identified the presence of mast/stem cell growth factor receptors. Together, these results lead to a diagnosis of GIST. The clinical findings, imaging modalities and pathological studies suggested that the GIST was a large and high‑risk tumor located in the abdomino‑pelvic cavity. The final surgical results confirmed these findings. Following conservative treatment with imatnib (400 mg, daily) for 6 months, the tumor became smaller and was suitable for surgery, which the patient received in December 2014. The final surgery confirmed the high‑risk GIST. Subsequent to the surgery, the patient was recommended to continue the use of imatnib with regular CT or MRI reexaminations every 3 months, which are planned to continue for 3 years.

References

1 

Novelli M, Rossi S, Rodriguez-Justo M, Taniere P, Seddon B, Toffolatti L, Sartor C, Hogendoorn PC, Sciot R, Van Glabbeke M, et al: DOG1 and CD117 are the antibodies of choice in the diagnosis of gastrointestinal stromal tumours. Histopathology. 57:259–270. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Su YY, Chiang NJ, Wu CC and Chen LT: Primary gastrointestinal stromal tumor of the liver in an anorectal melanoma survivor: A case report. Oncol Lett. 10:2366–2370. 2015.PubMed/NCBI

3 

Bár T, Sankot J, Adamová Z and Mičulka P: Extraintestinal GIST - case report. Rozhl Chir. 94:383–386. 2015.(In Czech). PubMed/NCBI

4 

Suryawanshi KH, Patil TB, Damle RP, Dravid NV and Surana A: Gastrointestinal stromal tumour of small intestine presenting as a mesenteric mass. J Clin Diagn Res. 8:FD14–FD16. 2014.PubMed/NCBI

5 

Sashidharan P, Matele A, Matele U, Al Felahi N and Kassem KF: Gastrointestinal stromal tumors: A case report. Oman Med J. 29:138–141. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Liang X, Yu H, Zhu LH, Wang XF and Cai XJ: Gastrointestinal stromal tumors of the duodenum: Surgical management and survival results. World J Gastroenterol. 19:6000–6010. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Salari M, Ahadi M, Hoseini SM, Mokhtari E, Gafarzadehgan K, Hashemian HR, Esmaeili B and Vossoughinia H: Gastrointestinal Stromal Tumors in Northeastern Iran: 46 Cases During 2003-2012. Middle East J Dig Dis. 7:161–165. 2015.PubMed/NCBI

8 

Rammohan A, Sathyanesan J, Rajendran K, Pitchaimuthu A, Perumal SK, Srinivasan U, Ramasamy R, Palaniappan R and Govindan M: A gist of gastrointestinal stromal tumors: A review. World J Gastrointest Oncol. 5:102–112. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Antonopoulos P, Leonardou P, Barbagiannis N, Alexiou K, Demonakou M and Economou N: Gastrointestinal and extragastrointestinal stromal tumors: Report of two cases and review of the literature. Case Rep Gastroenterol. 8:61–66. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Stamatakos M, Douzinas E, Stefanaki C, Safioleas P, Polyzou E, Levidou G and Safioleas M: Gastrointestinal stromal tumor. World J Surg Oncol. 7:61–70. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Sorour MA, Kassem MI, Ghazal A-H, El-Riwini MT and Abu Nasr A: Gastrointestinal stromal tumors (GIST) related emergencies. Int J Surg. 12:269–280. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Zhao X and Yue C: Gastrointestinal stromal tumor. J Gastrointest Oncol. 3:189–208. 2012.PubMed/NCBI

13 

Beham AW, Schaefer I-M, Schüler P, Cameron S and Ghadimi BM: Gastrointestinal stromal tumors. Int J Colorectal Dis. 27:689–700. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Giuliani J and Bonetti A: The occurrence of gastrointestinal stromal tumors and second malignancies. J Gastrointest Cancer. 46:408–412. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Gerrish ST and Smith JW: Gastrointestinal stromal tumors - diagnosis and management: A brief review. Ochsner J. 8:197–204. 2008.PubMed/NCBI

16 

Dickhoff C, Leguit RJ, Slors JF, Vervenne WL and Bemelman WA: Giant rectal gastrointestinal stromal tumors: A report of two cases. Case Rep Gastroenterol. 2:54–69. 2008. View Article : Google Scholar : PubMed/NCBI

17 

de Oliveira RP, Portari Filho PE, Iglesias AC, de Oliveira CA and Pannain VL: Comparative study of the different degrees of risk of gastrointestinal stromal tumor. Rev Col Bras Cir. 42:32–36. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Zhao WY, Xu J, Wang M, Zhang ZZ, Tu L, Wang CJ, Cao H and Zhang ZG: Evaluation of high-risk clinicopathological indicators in gastrointestinal stromal tumors for prognosis and imatinib treatment outcome. BMC Gastroenterol. 14:105–113. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Cai PQ, Lv XF, Tian L, Luo ZP, Mitteer RA Jr, Fan Y and Wu YP: CT characterization of duodenal gastrointestinal stromal tumors. AJR Am J Roentgenol. 204:988–993. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Serrano C and George S: Recent advances in the treatment of gastrointestinal stromal tumors. Ther Adv Med Oncol. 6:115–127. 2014. View Article : Google Scholar : PubMed/NCBI

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March 2016
Volume 11 Issue 3

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Copy and paste a formatted citation
APA
Wang, Y., Peng, J., & Huang, J. (2016). Giant and high-risk gastrointestinal stromal tumor in the abdomino-pelvic cavity: A case report. Oncology Letters, 11, 2035-2038. https://doi.org/10.3892/ol.2016.4196
MLA
Wang, Y., Peng, J., Huang, J."Giant and high-risk gastrointestinal stromal tumor in the abdomino-pelvic cavity: A case report". Oncology Letters 11.3 (2016): 2035-2038.
Chicago
Wang, Y., Peng, J., Huang, J."Giant and high-risk gastrointestinal stromal tumor in the abdomino-pelvic cavity: A case report". Oncology Letters 11, no. 3 (2016): 2035-2038. https://doi.org/10.3892/ol.2016.4196