Expression of SOX2 in oral squamous cell carcinoma and the association with lymph node metastasis (Review)

  • Authors:
    • Zhen‑Hu Ren
    • Chen‑Ping Zhang
    • Tong Ji
  • View Affiliations

  • Published online on: February 9, 2016     https://doi.org/10.3892/ol.2016.4207
  • Pages: 1973-1979
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Abstract

Oral squamous cell carcinomas (OSCCs) are a growing problem in the world. The various existing treatments have not markedly improved the survival rate of patients with OSCC during the past three decades. Novel treatment strategies are required. Sex determining region Y‑box 2 (SOX2) is a transcription factor that is involved in the maintenance of embryonic stem cell pluripotency and in multiple developmental processes. SOX2 expression was indicated to act as a prognostic factor in various types of tumors, including breast, colorectal, gastric and lung cancer and glioblastoma, and as a link between malignancy and stemness. Cancer stem cells (CSCs) may be responsible for the genesis, growth and metastatic spread of tumors. The poor survival outcomes for OSCC patients may be attributable to a poor selection of target cells for treatment, as current oral cancer therapies are generally aimed at the global mass of tumor. Therefore, the consideration that novel approaches to oral cancer may be targeted using SOX2 and CSCs appears reasonable. In order to better understand the oncogenic roles and the corresponding signal transduction pathways of the SOX2 protein, the present study emphasizes the role of SOX2 in OSCC, including the proteins associated with OSCC, and reviews the literature regarding the role of SOX2 in lymph node metastasis. The aim of the present study is to provide a reference for future studies that engage in research on the aforementioned subject.
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March-2016
Volume 11 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Ren ZH, Zhang CP and Ji T: Expression of SOX2 in oral squamous cell carcinoma and the association with lymph node metastasis (Review). Oncol Lett 11: 1973-1979, 2016
APA
Ren, Z., Zhang, C., & Ji, T. (2016). Expression of SOX2 in oral squamous cell carcinoma and the association with lymph node metastasis (Review). Oncology Letters, 11, 1973-1979. https://doi.org/10.3892/ol.2016.4207
MLA
Ren, Z., Zhang, C., Ji, T."Expression of SOX2 in oral squamous cell carcinoma and the association with lymph node metastasis (Review)". Oncology Letters 11.3 (2016): 1973-1979.
Chicago
Ren, Z., Zhang, C., Ji, T."Expression of SOX2 in oral squamous cell carcinoma and the association with lymph node metastasis (Review)". Oncology Letters 11, no. 3 (2016): 1973-1979. https://doi.org/10.3892/ol.2016.4207