Inflammatory pseudotumor of the pineal region: First reported case

Kuang,Ping‑Ding; Li,Qing‑Hai; Liu,Zi‑Yu; Tang,Jin‑Long; Dong,Fei; Wang,Ying; Zhu,Xiu‑Liang

doi:10.3892/ol.2016.4212

March-2016 Volume 11 Issue 3

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March-2016 Volume 11 Issue 3

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Article

Inflammatory pseudotumor of the pineal region: First reported case

Authors:
- Ping‑Ding Kuang
- Qing‑Hai Li
- Zi‑Yu Liu
- Jin‑Long Tang
- Fei Dong
- Ying Wang
- Xiu‑Liang Zhu
View Affiliations / Copyright

Affiliations: Department of Radiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China, Department of Pathology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China
Pages: 2127-2130
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Published online on: February 9, 2016

https://doi.org/10.3892/ol.2016.4212
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Abstract

Inflammatory pseudotumors originating in the central nervous system (CNS) are quite rare. To the best of our knowledge, the present study reports the first case of a inflammatory pseudotumor that developed in the pineal region, and describes the neuroimaging, morphological and immunohistochemical findings. A 53‑year‑old male presented with hearing loss that had been apparent for 1 year and blurred vision that had persisted for 10 months. Magnetic resonance imaging (MRI) demonstrated a homogeneously‑enhanced mass in the pineal region and obstructive hydrocephalus. A pathological examination revealed that the lesion was comprised predominantly of spindled cells in a collagenous background, with dense infiltrates of small lymphocytes, plasma cells and uninucleated histiocytes. Immunopositivity for cluster of differentiation (CD)138 was noted. Immunohistochemical staining showed that the cells were immunonegative for glial fibrillary acidic protein, S‑100, placental alkaline phosphatase, neurofilament and Pit‑Oct‑Unc class 5 homeobox 1. The Ki‑67 labeling index was <5%. The lymphocytic infiltrates consisted of CD3‑ and CD43‑positive T‑cells, and CD20‑ and CD79A‑positive B‑cells. Plasma cells displayed polytypic reactivity for immunoglobulin κ and λ light chains. Based on the MRI and the morphological and immunohistochemical analysis, a diagnosis of an inflammatory pseudotumor was formed. The patient underwent a surgical resection of the tumor and currently has a good prognosis.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Inflammatory pseudotumor of the pineal region: First reported case

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