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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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June-2016 Volume 11 Issue 6

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Case Report

Development of donor cell leukemia following peripheral blood stem cell transplantation for severe aplastic anemia: A case report

  • Authors:
    • Hongbing Ma
    • Ting Liu
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China
  • Pages: 3858-3862
    |
    Published online on: April 18, 2016
       https://doi.org/10.3892/ol.2016.4452
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Abstract

Donor cell leukemia (DCL) is a rare complication of hematopoietic stem cell transplantation (HSCT) which occurs in ~5% of all leukemic relapses. In the English literature, >60 cases of DCL have been reported, however, only two cases of DCL following HSCT for the treatment of severe aplastic anemia (SAA) have been described to date. In the present study, the case of a 25 year‑old male patient diagnosed with SAA, who underwent a peripheral blood stem cell transplantation (PBSCT) using cells obtained from a sibling with an identical human leukocyte antigen, is presented. The patient developed acute myeloid leukemia with an (8;21)(q22;q22) translocation and an extra copy of the chromosome 8 in donor cells 2.5 years following PBSCT, which was preceded by the development of Graves' disease 1 year following PBSCT. The leukemia achieved complete remission following 1 cycle of priming therapy, 2 cycles of consolidation chemotherapy with daunorubicin and cytarabine and maintenance therapy with interleukin‑2 (IL‑2). At present, the patient has discontinued IL‑2 therapy, and the DCL has been in molecular remission for >3 years. The present case indicates that chemotherapy and IL‑2 maintenance therapy are an effective treatment for DCL; hyperthyroidism was relieved following treatment, although hypothyroidism subsequently developed.
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Copy and paste a formatted citation
Spandidos Publications style
Ma H and Liu T: Development of donor cell leukemia following peripheral blood stem cell transplantation for severe aplastic anemia: A case report. Oncol Lett 11: 3858-3862, 2016.
APA
Ma, H., & Liu, T. (2016). Development of donor cell leukemia following peripheral blood stem cell transplantation for severe aplastic anemia: A case report. Oncology Letters, 11, 3858-3862. https://doi.org/10.3892/ol.2016.4452
MLA
Ma, H., Liu, T."Development of donor cell leukemia following peripheral blood stem cell transplantation for severe aplastic anemia: A case report". Oncology Letters 11.6 (2016): 3858-3862.
Chicago
Ma, H., Liu, T."Development of donor cell leukemia following peripheral blood stem cell transplantation for severe aplastic anemia: A case report". Oncology Letters 11, no. 6 (2016): 3858-3862. https://doi.org/10.3892/ol.2016.4452
Copy and paste a formatted citation
x
Spandidos Publications style
Ma H and Liu T: Development of donor cell leukemia following peripheral blood stem cell transplantation for severe aplastic anemia: A case report. Oncol Lett 11: 3858-3862, 2016.
APA
Ma, H., & Liu, T. (2016). Development of donor cell leukemia following peripheral blood stem cell transplantation for severe aplastic anemia: A case report. Oncology Letters, 11, 3858-3862. https://doi.org/10.3892/ol.2016.4452
MLA
Ma, H., Liu, T."Development of donor cell leukemia following peripheral blood stem cell transplantation for severe aplastic anemia: A case report". Oncology Letters 11.6 (2016): 3858-3862.
Chicago
Ma, H., Liu, T."Development of donor cell leukemia following peripheral blood stem cell transplantation for severe aplastic anemia: A case report". Oncology Letters 11, no. 6 (2016): 3858-3862. https://doi.org/10.3892/ol.2016.4452
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