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Nuclear localization of glutamate-cysteine ligase is associated with proliferation in head and neck squamous cell carcinoma

  • Authors:
    • Didier Dequanter
    • Maureen Van de Velde
    • Isabelle Bar
    • Vincent Nuyens
    • Alexandre Rousseau
    • Nathalie Nagy
    • Luc Vanhamm
    • Michel Vanhaeverbeek
    • Dany Brohée
    • Paul Delrée
    • Karim Zouaoui Boudjeltia
    • Philippe Lothaire
    • Pierrick Uzureau
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, University Hospital Center of Charleroi, André Vésale Hospital, Université Libre de Bruxelles, Montigny‑le‑Tilleul B‑611, Belgium, Interdisciplinary Cluster for Applied Genoproteomics, University of Liège, Liège B‑4000, Belgium, Department of Pathology, Institute of Pathology and Genetics, Gosselies B‑6041, Belgium, Laboratory of Experimental Medicine (ULB222), André Vésale Hospital, Université Libre de Bruxelles, Montigny‑le‑Tilleul B‑6110, Belgium , Department of Pathological Anatomy, University Hospital Center in Charleroi, André Vésale Hospital, Université Libre de Bruxelles, Montigny‑le‑Tilleul B‑6110, Belgium, Laboratory of Molecular Parasitology, Institute of Molecular Biology and Medicine, Université Libre de Bruxelles, Charleroi B‑6041, Belgium, Department of Internal Medicine, University Hospital Center in Charleroi, André Vésale Hospital, Université Libre de Bruxelles, Montigny‑le‑Tilleul B‑6110, Belgium, Department of Oncology, University Hospital Center in Charleroi, André Vésale Hospital, Université Libre de Bruxelles, Montigny‑le‑Tilleul B‑6110, Belgium
    Copyright: © Dequanter et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3660-3668
    |
    Published online on: April 19, 2016
       https://doi.org/10.3892/ol.2016.4458
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Abstract

Glutathione (GSH) is the keystone of the cellular response toward oxidative stress. Elevated GSH content correlates with increased resistance to chemotherapy and radiotherapy of head and neck (HN) tumors. The purpose of the present cross‑sectional study was to evaluate whether the expression of glutamate‑cysteine ligase (GCL) accounts for the increased GSH availability observed in HN squamous cell carcinoma (SCC). For that purpose, the messenger (m)RNA levels of the modifier (M) and catalytic (C) subunits of GCL and its putative regulators (namely, nuclear factor erythroid 2‑related factor 2, heme oxygenase‑1 and nuclear factor of kappa light polypeptide gene enhancer in B‑cells inhibitor, alpha) were monitored in 35 surgical resections of untreated HNSCC. The localization of GCLM was evaluated using in situ hybridization and immunohistochemistry. GCLM expression was significantly increased in tumor samples, compared with normal mucosa, both at the mRNA and protein level (P=0.029), but the pathway of GCLM activation remains to be elucidated. Protein expression of GCLM was detected in the cytoplasm and nucleus. GCLM and the proliferation marker Ki‑67 displayed a similar distribution, being both mainly expressed at the periphery of tumor lobules. The present study reported increased expression of GCL and the rate‑limiting enzyme of GSH synthesis, within HNSCC. The nuclear localization of GCLM and the concomitant expression of Ki‑67 suggested that the localization of GSH synthesis contributes to the protection against oxidative stress within hotspots of cell proliferation.
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1 

Cooper JS, Porter K, Mallin K, Hoffman HT, Weber RS, Ang KK, Gay EG and Langer CJ: National Cancer Database report on cancer of the head and neck: 10-year update. Head Neck. 31:748–758. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Dandekar M and D'Cruz A: Organ preservation strategies: Review of literature and their applicability in developing nations. South Asian J Cancer. 3:147–150. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Gupta SC, Hevia D, Patchva S, Park B, Koh W and Aggarwal BB: Upsides and downsides of reactive oxygen species for cancer: The roles of reactive oxygen species in tumorigenesis, prevention and therapy. Antioxid Redox Signal. 16:1295–1322. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Traverso N, Ricciarelli R, Nitti M, Marengo B, Furfaro AL, Pronzato MA, Marinari UM and Domenicotti C: Role of glutathione in cancer progression and chemoresistance. Oxid Med Cell Longev. 2013:9729132013. View Article : Google Scholar : PubMed/NCBI

5 

Lu SC: Glutathione synthesis. Biochim Biophys Acta. 1830:3143–3153. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Chen Y, Shertzer HG, Schneider SN, Nebert DW and Dalton TP: Glutamate cysteine ligase catalysis: Dependence on ATP and modifier subunit for regulation of tissue glutathione levels. J Biol Chem. 280:33766–33774. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Dahl EL and Mulcahy RT: Cell-type specific differences in glutamate cysteine ligase transcriptional regulation demonstrate independent subunit control. Toxicol Sci. 61:265–272. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Cai J, Huang ZZ and Lu SC: Differential regulation of gamma-glutamylcysteine synthetase heavy and light subunit gene expression. Biochem J. 326:167–172. 1997. View Article : Google Scholar : PubMed/NCBI

9 

Krzywanski DM, Dickinson DA, Iles KE, Wigley AF, Franklin CC, Liu RM, Kavanagh TJ and Forman HJ: Variable regulation of glutamate cysteine ligase subunit proteins affects glutathione biosynthesis in response to oxidative stress. Arch Biochem Biophys. 423:116–125. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Yang H, Magilnick N, Ou X and Lu SC: Tumour necrosis factor alpha induces co-ordinated activation of rat GSH synthetic enzymes via nuclear factor kappaB and activator protein-1. Biochem J. 391:399–408. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Wild AC, Moinova HR and Mulcahy RT: Regulation of gamma-glutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2. J Biol Chem. 274:33627–33636. 1999. View Article : Google Scholar : PubMed/NCBI

12 

Yang H, Wang J, Huang ZZ, Ou X and Lu SC: Cloning and characterization of the 5′-flanking region of the rat glutamate-cysteine ligase catalytic subunit. Biochem J. 455:447–455. 2001. View Article : Google Scholar

13 

Reuter S, Gupta SC, Chaturvedi MM and Aggarwal BB: Oxidative stress, inflammation, and cancer: How are they linked? Free Radic Biol Med. 49:1603–1616. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Yang H, Magilnick N, Lee C, Kalmaz D, Ou X, Chan JY and Lu SC: Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1. Mol Cell Biol. 25:5933–5946. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Peng Z, Geh E, Chen L, Meng Q, Fan Y, Sartor M, Shertzer HG, Liu ZG, Puga A and Xia Y: Inhibitor of kappaB kinase beta regulates redox homeostasis by controlling the constitutive levels of glutathione. Mol Pharmacol. 77:784–792. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Baird L and Dinkova-Kostova AT: The cytoprotective role of the Keap1-Nrf2 pathway. Arch Toxicol. 85:241–272. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Na HK and Surh YJ: Oncogenic potential of Nrf2 and its principal target protein heme oxygenase-1. Free Radic Biol Med. 67:353–365. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Gamcsik MP, Kasibhatla MS, Teeter SD and Colvin OM: Glutathione levels in human tumors. Biomarkers. 17:671–691. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Dequanter D, Van de Velde M, Nuyens V, Nagy N, Van Antwerpen P, Vanhamme L, Zouaoui Boudjeltia K, Vanhaeverbeek M, Brohée D and Lothaire P: Assessment of oxidative stress in tumors and histologically normal mucosa from patients with head and neck squamous cell carcinoma: A preliminary study. Eur J Cancer Prev. 22:558–560. 2013. View Article : Google Scholar : PubMed/NCBI

20 

van der Schroeff MP and de Baatenburg Jong RJ: Staging and prognosis in head and neck cancer. Oral Oncol. 4–5:356–360. 2009. View Article : Google Scholar

21 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Varghese F, Bukhari AB, Malhotra R and De A: IHC Profiler: An open source plugin for the quantitative evaluation and automated scoring of immunohistochemistry images of human tissue samples. PLoS One. 9:e968012014. View Article : Google Scholar : PubMed/NCBI

23 

Sahoo P, Wilkins C and Yeager J: Threshold selection using Renyi's entropy. Pattern Recognit. 30:71–84. 1997. View Article : Google Scholar

24 

Bottero V, Imbert V, Frelin C, Formento JL and Peyron JF: Monitoring NF-kappa B transactivation potential via real-time PCR quantification of I kappa B-alpha gene expression. Mol Diagn. 7:187–194. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Edström SS, Gustafsson B, Stenman G, Lydén E, Stein H and Westin T: Proliferative pattern of head and neck cancer. Am J Surg. 162:412–416. 1991. View Article : Google Scholar : PubMed/NCBI

26 

Kearsley JH, Furlong KL, Cooke RA and Waters MJ: An immunohistochemical assessment of cellular proliferation markers in head and neck squamous cell cancers. Br J Cancer. 61:821–827. 1990. View Article : Google Scholar : PubMed/NCBI

27 

Yellin SA, Davidson BJ, Pinto JT, Sacks PG, Qiao C and Schantz SP: Relationship of glutathione and glutathione- S-transferase to cisplatin sensitivity in human head and neck squamous carcinoma cell lines. Cancer Lett. 85:223–232. 1994. View Article : Google Scholar : PubMed/NCBI

28 

Kato T, Duffey DC, Ondrey FG, Dong G, Chen Z, Cook JA, Mitchell JB and Van Waes C: Cisplatin and radiation sensitivity in human head and neck squamous carcinomas are independently modulated by glutathione and transcription factor NF-kappaB. Head Neck. 22:748–759. 2000. View Article : Google Scholar : PubMed/NCBI

29 

Bhattathiri VN, Sreelekha TT, Sebastian P, Remani P, Chandini R, Vijayakumar T and Nair MK: Influence of plasma GSH level on acute radiation mucositis of the oral cavity. Int J Radiat Oncol Biol Phys. 29:383–386. 1994. View Article : Google Scholar : PubMed/NCBI

30 

Stacy DR, Ely K, Massion PP, Yarbrough WG, Hallahan DE, Sekhar KR and Freeman ML: Increased expression of nuclear factor E2 p45-related factor 2 (NRF2) in head and neck squamous cell carcinomas. Head Neck. 28:813–818. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Loercher A, Lee TL, Ricker JL, Howard A, Geoghegen J, Chen Z, Sunwoo JB, Sitcheran R, Chuang EY, Mitchell JB, et al: Nuclear factor-kappaB is an important modulator of the altered gene expression profile and malignant phenotype in squamous cell carcinoma. Cancer Res. 64:6511–6523. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Kaarteenaho-Wiik R and Kinnula VL: Distribution of antioxidant enzymes in developing human lung, respiratory distress syndrome, and bronchopulmonary dysplasia. J Histochem Cytochem. 52:1231–1240. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Nishimura T, Newkirk K, Sessions RB, Andrews PA, Trock BJ, Rusmussen AA, Montogomery EA, Bischoff EK, Hanigan MH and Cullen KJ: Association between expression of glutathione-associated enzymes and response to platinum-based chemotherapy in head and neck cancer. Chem Biol Interact. 111–112:187–198. 1998. View Article : Google Scholar

34 

Lee JI, Kang J and Stipanuk MH: Differential regulation of glutamate-cysteine ligase subunit expression and increased holoenzyme formation in response to cysteine deprivation. Biochem J. 393:181–190. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Watanabe S, Watanabe R, Oton-Leite AF, Alencar RC, Oliveira JC, Leles CR, Batista AC and Mendonça EF: Analysis of cell proliferation and pattern of invasion in oral squamous cell carcinoma. J Oral Sci. 52:417–424. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Radyuk SN, Rebrin I, Luchak JM, Michalak K, Klichko VI, Sohal RS and Orr WC: The catalytic subunit of Drosophila glutamate-cysteine ligase is a nucleocytoplasmic shuttling protein. J Biol Chem. 284:2266–2274. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Markovic J, Borrás C, Ortega A, Sastre J, Viña J and Pallardó FV: Glutathione is recruited into the nucleus in early phases of cell proliferation. J Biol Chem. 282:20416–20424. 2007. View Article : Google Scholar : PubMed/NCBI

38 

García-Giménez JL, Markovic J, Dasí F, Queval G, Schnaubelt D, Foyer CH and Pallardó FV: Nuclear glutathione. Biochim Biophys Acta. 1830:3304–3316. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Dequanter D, Van de Velde M, Bar I, Nuyens V, Rousseau A, Nagy N, Vanhamm L, Vanhaeverbeek M, Brohée D, Delrée P, Delrée P, et al: Nuclear localization of glutamate-cysteine ligase is associated with proliferation in head and neck squamous cell carcinoma. Oncol Lett 11: 3660-3668, 2016.
APA
Dequanter, D., Van de Velde, M., Bar, I., Nuyens, V., Rousseau, A., Nagy, N. ... Uzureau, P. (2016). Nuclear localization of glutamate-cysteine ligase is associated with proliferation in head and neck squamous cell carcinoma. Oncology Letters, 11, 3660-3668. https://doi.org/10.3892/ol.2016.4458
MLA
Dequanter, D., Van de Velde, M., Bar, I., Nuyens, V., Rousseau, A., Nagy, N., Vanhamm, L., Vanhaeverbeek, M., Brohée, D., Delrée, P., Zouaoui Boudjeltia, K., Lothaire, P., Uzureau, P."Nuclear localization of glutamate-cysteine ligase is associated with proliferation in head and neck squamous cell carcinoma". Oncology Letters 11.6 (2016): 3660-3668.
Chicago
Dequanter, D., Van de Velde, M., Bar, I., Nuyens, V., Rousseau, A., Nagy, N., Vanhamm, L., Vanhaeverbeek, M., Brohée, D., Delrée, P., Zouaoui Boudjeltia, K., Lothaire, P., Uzureau, P."Nuclear localization of glutamate-cysteine ligase is associated with proliferation in head and neck squamous cell carcinoma". Oncology Letters 11, no. 6 (2016): 3660-3668. https://doi.org/10.3892/ol.2016.4458
Copy and paste a formatted citation
x
Spandidos Publications style
Dequanter D, Van de Velde M, Bar I, Nuyens V, Rousseau A, Nagy N, Vanhamm L, Vanhaeverbeek M, Brohée D, Delrée P, Delrée P, et al: Nuclear localization of glutamate-cysteine ligase is associated with proliferation in head and neck squamous cell carcinoma. Oncol Lett 11: 3660-3668, 2016.
APA
Dequanter, D., Van de Velde, M., Bar, I., Nuyens, V., Rousseau, A., Nagy, N. ... Uzureau, P. (2016). Nuclear localization of glutamate-cysteine ligase is associated with proliferation in head and neck squamous cell carcinoma. Oncology Letters, 11, 3660-3668. https://doi.org/10.3892/ol.2016.4458
MLA
Dequanter, D., Van de Velde, M., Bar, I., Nuyens, V., Rousseau, A., Nagy, N., Vanhamm, L., Vanhaeverbeek, M., Brohée, D., Delrée, P., Zouaoui Boudjeltia, K., Lothaire, P., Uzureau, P."Nuclear localization of glutamate-cysteine ligase is associated with proliferation in head and neck squamous cell carcinoma". Oncology Letters 11.6 (2016): 3660-3668.
Chicago
Dequanter, D., Van de Velde, M., Bar, I., Nuyens, V., Rousseau, A., Nagy, N., Vanhamm, L., Vanhaeverbeek, M., Brohée, D., Delrée, P., Zouaoui Boudjeltia, K., Lothaire, P., Uzureau, P."Nuclear localization of glutamate-cysteine ligase is associated with proliferation in head and neck squamous cell carcinoma". Oncology Letters 11, no. 6 (2016): 3660-3668. https://doi.org/10.3892/ol.2016.4458
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