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Article Open Access

Effect of taxol on the expression of FoxM1 ovarian cancer-associated gene

  • Authors:
    • Zeng Liu
    • Yu Xiao
    • Siqing Ning
    • Zhao Yuan Li
    • Yuanyuan Zhu
    • Gang Hu
  • View Affiliations / Copyright

    Affiliations: Department of Nuclear Medicine, Central Hospital of Xiangyang, Xiangyang, Hubei 441021, P.R. China, State Drug Clinical Trial Agency, Sichuan Provincial People's Hospital, Sichuan Academy of Medical Science, Chengdu, Sichuan 610072, P.R. China, Department of Nuclear Medicine, Xiangyang No. 1 People's Hospital, Xiangyang, Hubei 441000, P.R. China, Department of Breast Surgery, Sichuan Provincial People's Hospital, Sichuan Academy of Medical Science, Chengdu, Sichuan 610072, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4035-4039
    |
    Published online on: April 22, 2016
       https://doi.org/10.3892/ol.2016.4490
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Abstract

The incidence of ovarian cancer in women has been on the increase in recent years. The aim of the present study was to examine the effects of taxol on the expression of ovarian cancer‑associated gene forkhead box transcription factor M1 (FoxM1) and its therapeutic effects for ovarian cancer. The expression of FoxM1 gene was examined in patients with or without ovarian cancer. RNA and protein levels of FoxM1 gene of ovarian cancer patients were detected at different time periods (1, 3, 6, 8, 12 and 24 months) after treatment with taxol. The results showed that the mRNA level of FoxM1 gene in patients with ovarian cancer was significantly higher than that in normal women (P<0.05). With time and progression of the disease, the expression of FoxM1 gene significantly increased in the patients not being administered taxol, whereas the expression of FoxM1 in the patients administered taxol was significantly lower comparatively (P<0.05). In conclusion, an asssociation was identified between the FoxM1 gene and ovarian cancer. The FoxM1 gene therefore promotes the generation and deterioration of ovarian cancer, whereas taxol reduces it. These findings provide a certain theoretical basis for the later treatment of ovarian cancer disease.
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Copy and paste a formatted citation
Spandidos Publications style
Liu Z, Xiao Y, Ning S, Li ZY, Zhu Y and Hu G: Effect of taxol on the expression of FoxM1 ovarian cancer-associated gene. Oncol Lett 11: 4035-4039, 2016.
APA
Liu, Z., Xiao, Y., Ning, S., Li, Z.Y., Zhu, Y., & Hu, G. (2016). Effect of taxol on the expression of FoxM1 ovarian cancer-associated gene. Oncology Letters, 11, 4035-4039. https://doi.org/10.3892/ol.2016.4490
MLA
Liu, Z., Xiao, Y., Ning, S., Li, Z. Y., Zhu, Y., Hu, G."Effect of taxol on the expression of FoxM1 ovarian cancer-associated gene". Oncology Letters 11.6 (2016): 4035-4039.
Chicago
Liu, Z., Xiao, Y., Ning, S., Li, Z. Y., Zhu, Y., Hu, G."Effect of taxol on the expression of FoxM1 ovarian cancer-associated gene". Oncology Letters 11, no. 6 (2016): 4035-4039. https://doi.org/10.3892/ol.2016.4490
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Z, Xiao Y, Ning S, Li ZY, Zhu Y and Hu G: Effect of taxol on the expression of FoxM1 ovarian cancer-associated gene. Oncol Lett 11: 4035-4039, 2016.
APA
Liu, Z., Xiao, Y., Ning, S., Li, Z.Y., Zhu, Y., & Hu, G. (2016). Effect of taxol on the expression of FoxM1 ovarian cancer-associated gene. Oncology Letters, 11, 4035-4039. https://doi.org/10.3892/ol.2016.4490
MLA
Liu, Z., Xiao, Y., Ning, S., Li, Z. Y., Zhu, Y., Hu, G."Effect of taxol on the expression of FoxM1 ovarian cancer-associated gene". Oncology Letters 11.6 (2016): 4035-4039.
Chicago
Liu, Z., Xiao, Y., Ning, S., Li, Z. Y., Zhu, Y., Hu, G."Effect of taxol on the expression of FoxM1 ovarian cancer-associated gene". Oncology Letters 11, no. 6 (2016): 4035-4039. https://doi.org/10.3892/ol.2016.4490
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