Effect of taxol on the expression of FoxM1 ovarian cancer-associated gene

Liu,Zeng; Xiao,Yu; Ning,Siqing; Li,Zhao  Yuan; Zhu,Yuanyuan; Hu,Gang

doi:10.3892/ol.2016.4490

Effect of taxol on the expression of FoxM1 ovarian cancer-associated gene

Authors:
- Zeng Liu
- Yu Xiao
- Siqing Ning
- Zhao Yuan Li
- Yuanyuan Zhu
- Gang Hu
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Affiliations: Department of Nuclear Medicine, Central Hospital of Xiangyang, Xiangyang, Hubei 441021, P.R. China, State Drug Clinical Trial Agency, Sichuan Provincial People's Hospital, Sichuan Academy of Medical Science, Chengdu, Sichuan 610072, P.R. China, Department of Nuclear Medicine, Xiangyang No. 1 People's Hospital, Xiangyang, Hubei 441000, P.R. China, Department of Breast Surgery, Sichuan Provincial People's Hospital, Sichuan Academy of Medical Science, Chengdu, Sichuan 610072, P.R. China
Published online on: April 22, 2016 https://doi.org/10.3892/ol.2016.4490
Pages: 4035-4039
Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The incidence of ovarian cancer in women has been on the increase in recent years. The aim of the present study was to examine the effects of taxol on the expression of ovarian cancer‑associated gene forkhead box transcription factor M1 (FoxM1) and its therapeutic effects for ovarian cancer. The expression of FoxM1 gene was examined in patients with or without ovarian cancer. RNA and protein levels of FoxM1 gene of ovarian cancer patients were detected at different time periods (1, 3, 6, 8, 12 and 24 months) after treatment with taxol. The results showed that the mRNA level of FoxM1 gene in patients with ovarian cancer was significantly higher than that in normal women (P<0.05). With time and progression of the disease, the expression of FoxM1 gene significantly increased in the patients not being administered taxol, whereas the expression of FoxM1 in the patients administered taxol was significantly lower comparatively (P<0.05). In conclusion, an asssociation was identified between the FoxM1 gene and ovarian cancer. The FoxM1 gene therefore promotes the generation and deterioration of ovarian cancer, whereas taxol reduces it. These findings provide a certain theoretical basis for the later treatment of ovarian cancer disease.

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1	Zheng RS, Zhang SW, Wu LY, Li GL, Zhao P, Hao J and Chen WQ: Report of incidence and mortality from China cancer registries in 2008. China Cancer. 21:1–12. 2012.
2	Pei GJ, Fu L, Cui YL, Gao LH, Wang WL and Lu WQ: Meta-analysis of risk factors of breast cancer in Chinese women. China Cancer. 21:1–12. 2012.
3	Laoukili J, Stahl M and Medema RH: FoxM1: At the crossroads of ageing and cancer. Biochim Biophys Acta. 1775:92–102. 2007.PubMed/NCBI
4	Yap KL, Fraley SI, Thiaville MM, Jinawath N, Nakayama K, Wang J, Wang TL, Wirtz D and Shih IeM: NAC1 is an actin-binding protein that is essential for effective cytokinesis in cancer cells. Cancer Res. 72:4085–4096. 2012. View Article : Google Scholar : PubMed/NCBI
5	He SY, Shen HW, Xu L, Zhao XH, Yuan L, Niu G, You ZS and Yao SZ: FoxM1 promotes tumor cell invasion and correlates with poor prognosis in early-stage cervical cancer. Gynecol Oncol. 127:601–610. 2012. View Article : Google Scholar : PubMed/NCBI
6	Wang Z, Ahmad A, Li Y, Banerjee S, Kong D and Sarkar FH: Forkhead box M1 transcription factor: A novel target for cancer therapy. Cancer Treat Rev. 36:151–156. 2010. View Article : Google Scholar : PubMed/NCBI
7	Yeasmin S, Nakayama K, Rahman MT, Rahman M, Ishikawa M, Katagiri A, Iida K, Nakayama N, Otuski Y, Kobayashi H, et al: Biological and clinical significance of NAC1 expression in cervical carcinomas: A comparative study between squamous cell carcinomas and adenocarcinomas/adenosquamous carcinomas. Hum Pathol. 43:506–519. 2012. View Article : Google Scholar : PubMed/NCBI
8	Zhang Y, Cheng Y, Ren X, Hori T, Huber-Keener KJ, Zhang L, Yap KL, Liu D, Shantz L, Qin ZH, et al: Dysfunction of nucleus accumbens-1 activates cellular senescence and inhibits tumor cell proliferation and oncogenesis. Cancer Res. 72:4262–4275. 2012. View Article : Google Scholar : PubMed/NCBI
9	Chen YZ, Chen KZ and Zeng JJ: Observation and nursing oftaxol in the treatment of cancer chemotherapy. J Qilu Nurs. 15:49–50. 2009.(In Chinese).
10	Zhu HC, Zhao BZ, Zheng XZ and Zhu YT: The effect of taxol on the expression of Bcl-2 and Bax in colon carcinoma HT-29 cells. Chin Med Mod Dist Educ Chin. 10:141–142. 2012.(In Chinese).
11	Zhang Y, Cheng Y, Ren X, Zhang L, Yap KL, Wu H, Patel R, Liu D, Qin ZH, Shih IM and Yang JM: NAC1 modulates sensitivity of ovarian cancer cells to cisplatin by altering the HMGB1-mediated autophagic response. Oncogene. 31:1055–1064. 2012. View Article : Google Scholar : PubMed/NCBI
12	Okazaki K, Nakayama N, Nariai Y, Nakayama K, Miyazaki K, Maruyama R, Kato H, Kosugi S, Urano T and Sakashita G: Nuclear localization signal in a cancer-related transcriptional regulator protein NAC1. Carcinogenesis. 33:1854–1862. 2012. View Article : Google Scholar : PubMed/NCBI
13	Wu PH, Hung SH, Ren T, Shih IeM and Tseng Y: Cell cycle-dependent alteration in NAC1 nuclear body dynamics and morphology. Phys Biol. 8:0150052011. View Article : Google Scholar : PubMed/NCBI
14	Padda RS, Gkouvatsos K, Guido M, Mui J, Vali H and Pantopoulos K: A high-fat diet modulates iron metabolism but does not promote liver fibrosis in hemochromatotic Hjv^−/− mice. Am J Physiol Gastrointest Liver Physiol. 308:G251–G261. 2015. View Article : Google Scholar : PubMed/NCBI
15	Francis RE, Myatt SS, Krol J, Hartman J, Peck B, McGovern UB, Wang J, Guest SK, Filipovic A, Gojis O, et al: FoxM1 is a downstream target and marker of HER2 overexpression in breast cancer. Int J Oncol. 35:57–68. 2009.PubMed/NCBI
16	Yoshida Y, Wang IC, Yoder HM, Davidson NO and Costa RH: The forkhead box M1 transcription factor contributes to the development and growth of mouse colorectal cancer. Gastroenterology. 132:1420–1431. 2007. View Article : Google Scholar : PubMed/NCBI
17	Yan XD and Pan LY: Comparative proteomic analysis of platinum drug resistance related proteins in ovarian cancer and the research on the function of drug resistance related protein Annexin A3. Chin J Obstet Gynecol. 41:584–587. 2006.(In Chinese).
18	Sun P and Bai P: An analysis of prognostic factors in 32 cases with transitional cell carcinoma of the ovary. J Chin Oncol. 17:97–100. 2011.(In Chinese).
19	Chen LL: Ovarian epithelium carcinoma induce abnormal differentiation of dendritic cell precursors (unpublished PhD thesis). Zhejiang University. 2009.
20	Gong YQ, Han FJ and Wu XK: Advances in etiology of epithelial ovarian cancer. J Med Res. 18–20. 2010.
21	Wani MC, Taylor HL, Wall ME, Coggon P and McPhail AT: Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J Am Chem Soc. 93:2325–2327. 1971. View Article : Google Scholar : PubMed/NCBI
22	Wang ZH, Zeng HX and Chang XH: A experiment study of effects on glycometabolism after the application of cortisol in chemotherapy includes taxoll. Prog Obstet Gynecol. 19:206–209. 2010.(In Chinese).
23	Schiff PB, Fant J and Horwitz SB: Promotion of microtubule assembly in vitro by taxol. Nature. 277:665–667. 1979. View Article : Google Scholar : PubMed/NCBI
24	Schiff PB and Horwitz SB: Taxol stabilizes microtubulesin mouse fibroblast cells. Proc Natl Acad Sci USA. 77:1561–1565. 1980. View Article : Google Scholar : PubMed/NCBI