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Article

Impact and mechanism of non-steroidal anti-inflammatory drugs combined with chemotherapeutic drugs on human lung cancer-nude mouse transplanted tumors

  • Authors:
    • Weiyi Sun
    • Gang Chen
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China, Department of Respiratory, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China
  • Pages: 4193-4199
    |
    Published online on: April 25, 2016
       https://doi.org/10.3892/ol.2016.4493
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Abstract

The present study aimed to investigate the impact of indomethacin treatment combined with oxaliplatin treatment on the expression of cluster of differentiation 44 variant 6 (CD44v6), matrix metalloproteinase-2 (MMP-2) and survivin in human lung cancer‑nude mouse transplanted tumors. The human lung adenocarcinoma (A549)‑nude mouse transplanted tumor model was established, and the mice were divided into a control group, an indomethacin treatment group, an oxaliplatin treatment group and an indomethacin-oxaliplatin combination treatment group. The tumor inhibition rate was calculated following sacrificing of the mice. Immunohistochemical staining and fluorescence reverse transcription‑quantitative polymerase chain reaction were utilized to detect the protein and messenger (m)RNA expression of CD44v6, MMP‑2 and survivin. The tumor inhibition rates of the indomethacin group, the oxaliplatin group and the combination group were 26.67, 47.70 and 68.88%, respectively. The protein and mRNA expression levels of CD44v6, MMP‑2 and survivin in the transplanted tumors of each treatment group were reduced compared with the control group (P<0.05), and those of the combination group were lower compared with the single‑drug treatment groups (P<0.05). Survivin and MMP‑2, MMP‑2 and CD44v6, and MMP‑2 and CD44v6 all exhibited linear positive correlation. The present study provides evidence that the administration of indomethacin alone, or in combination with oxaliplatin, may significantly inhibit the growth of lung cancer‑nude mouse transplanted tumors and the expression of CD44v6, MMP‑2 and survivin inside the tumor. The combination of non‑steroidal anti‑inflammatory drugs with chemotherapeutic drugs may improve the antitumor effects.
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Copy and paste a formatted citation
Spandidos Publications style
Sun W and Chen G: Impact and mechanism of non-steroidal anti-inflammatory drugs combined with chemotherapeutic drugs on human lung cancer-nude mouse transplanted tumors. Oncol Lett 11: 4193-4199, 2016.
APA
Sun, W., & Chen, G. (2016). Impact and mechanism of non-steroidal anti-inflammatory drugs combined with chemotherapeutic drugs on human lung cancer-nude mouse transplanted tumors. Oncology Letters, 11, 4193-4199. https://doi.org/10.3892/ol.2016.4493
MLA
Sun, W., Chen, G."Impact and mechanism of non-steroidal anti-inflammatory drugs combined with chemotherapeutic drugs on human lung cancer-nude mouse transplanted tumors". Oncology Letters 11.6 (2016): 4193-4199.
Chicago
Sun, W., Chen, G."Impact and mechanism of non-steroidal anti-inflammatory drugs combined with chemotherapeutic drugs on human lung cancer-nude mouse transplanted tumors". Oncology Letters 11, no. 6 (2016): 4193-4199. https://doi.org/10.3892/ol.2016.4493
Copy and paste a formatted citation
x
Spandidos Publications style
Sun W and Chen G: Impact and mechanism of non-steroidal anti-inflammatory drugs combined with chemotherapeutic drugs on human lung cancer-nude mouse transplanted tumors. Oncol Lett 11: 4193-4199, 2016.
APA
Sun, W., & Chen, G. (2016). Impact and mechanism of non-steroidal anti-inflammatory drugs combined with chemotherapeutic drugs on human lung cancer-nude mouse transplanted tumors. Oncology Letters, 11, 4193-4199. https://doi.org/10.3892/ol.2016.4493
MLA
Sun, W., Chen, G."Impact and mechanism of non-steroidal anti-inflammatory drugs combined with chemotherapeutic drugs on human lung cancer-nude mouse transplanted tumors". Oncology Letters 11.6 (2016): 4193-4199.
Chicago
Sun, W., Chen, G."Impact and mechanism of non-steroidal anti-inflammatory drugs combined with chemotherapeutic drugs on human lung cancer-nude mouse transplanted tumors". Oncology Letters 11, no. 6 (2016): 4193-4199. https://doi.org/10.3892/ol.2016.4493
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