Simultaneous occurrence of Hodgkin's lymphoma and multiple myeloma: A case report and review of the literature

Huang,Chen; Zhao,Guimin; Wang,Lianjing; Zhang,Huichao; Wu,Xiaolin; Zhang,Mingzeng; Ma,Ruijuan; Wang,Ling; Liu,Yueping; Liu,Lihong

doi:10.3892/ol.2016.4503

Simultaneous occurrence of Hodgkin's lymphoma and multiple myeloma: A case report and review of the literature

Authors:
- Chen Huang
- Guimin Zhao
- Lianjing Wang
- Huichao Zhang
- Xiaolin Wu
- Mingzeng Zhang
- Ruijuan Ma
- Ling Wang
- Yueping Liu
- Lihong Liu
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Affiliations: Department of Hematology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, Department of Inspection, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, Department of Pathology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China
Published online on: April 27, 2016 https://doi.org/10.3892/ol.2016.4503
Pages: 4139-4143

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Abstract

Hodgkin's lymphoma (HL) is a type of hematological neoplasm that generally appears alone, with a low incidence. The majority of cases histopathologically present as B‑cell lymphoma. Multiple myeloma (MM) is defined as the neoplastic proliferation of a single clone of plasma cells producing a monoclonal immunoglobulin (Ig). The coexistence of HL and MM is rare, however, the present study reports such a case. On May 31, 2012, a 45‑year‑old man was diagnosed with HL, stage III, 31 months ago. At the same time, computed tomography and magnetic resonance imaging showed osteolytic lesions, a significant increase in IgA λ chains, and multiple myeloma cells on bone marrow aspiration. Following 8 cycles of chemotherapy, the patient received maintenance treatment with thalidomide and dexamethasone. During 2 years of follow‑up, the patient has maintained a complete response for HL and a stable disease state for MM. The coexistence of HL and MM is rare. Further study of such cases may explain the associations between these two tumors and aid the production of effective treatment options.

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