Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
June-2016 Volume 11 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2016 Volume 11 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report

Simultaneous occurrence of Hodgkin's lymphoma and multiple myeloma: A case report and review of the literature

  • Authors:
    • Chen Huang
    • Guimin Zhao
    • Lianjing Wang
    • Huichao Zhang
    • Xiaolin Wu
    • Mingzeng Zhang
    • Ruijuan Ma
    • Ling Wang
    • Yueping Liu
    • Lihong Liu
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, Department of Inspection, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, Department of Pathology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China
  • Pages: 4139-4143
    |
    Published online on: April 27, 2016
       https://doi.org/10.3892/ol.2016.4503
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Hodgkin's lymphoma (HL) is a type of hematological neoplasm that generally appears alone, with a low incidence. The majority of cases histopathologically present as B‑cell lymphoma. Multiple myeloma (MM) is defined as the neoplastic proliferation of a single clone of plasma cells producing a monoclonal immunoglobulin (Ig). The coexistence of HL and MM is rare, however, the present study reports such a case. On May 31, 2012, a 45‑year‑old man was diagnosed with HL, stage III, 31 months ago. At the same time, computed tomography and magnetic resonance imaging showed osteolytic lesions, a significant increase in IgA λ chains, and multiple myeloma cells on bone marrow aspiration. Following 8 cycles of chemotherapy, the patient received maintenance treatment with thalidomide and dexamethasone. During 2 years of follow‑up, the patient has maintained a complete response for HL and a stable disease state for MM. The coexistence of HL and MM is rare. Further study of such cases may explain the associations between these two tumors and aid the production of effective treatment options.
View Figures

Figure 1

Figure 2

View References

1. 

Townsend W and Linch D: Hodgkin's lymphoma in adults. Lancet. 380:836–847. 2012. View Article : Google Scholar : PubMed/NCBI

2. 

Glaser SL and Hsu JL: Hodgkin's disease in Asians: Incidence patterns and risk factors in population-based data. Leuk Res. 26:261–269. 2002. View Article : Google Scholar : PubMed/NCBI

3. 

Gobbi PG, Ferreri AJ, Ponzoni M and Levis A: Hodgkin lymphoma. Crit Rev Oncol Hematol. 85:216–237. 2013. View Article : Google Scholar : PubMed/NCBI

4. 

Klasa RJ, Connors JM, Fairey R, Gascoyne R, Hoskins P, O'Reilly S, Shenkier T, Voss K and Wilson K: British Columbia Cancer Agency (BCCA): Treatment of early stage Hodgkin's disease: Improved outcome with brief chemotherapy and radiotherapy without staging laparotomy. Annal Oncol. 7(Suppl 3): 211996.

5. 

Raab MS, Podar K, Breitkreutz I, Richardson PG and Anderson KC: Multiple myeloma. Lancet. 374:324–339. 2009. View Article : Google Scholar : PubMed/NCBI

6. 

Palumbo A and Anderson K: Multiple myeloma: N Engl J Med. 364:1046–1060. 2011.

7. 

Sonneveld P, Schmidt-Wolf IG, van der Holt B, El Jarari L, Bertsch U, Salwender H, Zweegman S, Vellenga E, Broyl A, Blau IW, et al: Bortezomib induction and maintenance treatment in patients with newly diagnosed multiple myeloma: Results of the randomized phase III HOVON-65/ GMMG-HD4 trial. J Clin Oncol. 30:2946–2955. 2012. View Article : Google Scholar : PubMed/NCBI

8. 

Diefenbach C and Advani R: Customized targeted therapy in Hodgkin lymphoma: Hype or hope? Hematol Oncol Clin North Am. 28:105–122. 2014. View Article : Google Scholar : PubMed/NCBI

9. 

Tosi P: Diagnosis and treatment of bone disease in multiple myeloma: Spotlight on spinal involvement. Scientifica (Cairo). 2013:1045462013.PubMed/NCBI

10. 

Jemal A, Siegel R, Xu J and Ward E: Cancer statistics, 2010. CA Cancer J Clin. 60:277–300. 2010. View Article : Google Scholar : PubMed/NCBI

11. 

Sabattini E, Bisgaard K, Ascani S, Poggi S, Piccioli M, Ceccarelli C, Pieri F, Fraternali-Orcioni G and Pileri SA: The EnVision++ system: A new immunohistochemical method for diagnostics and research. Critical comparisonwith the APAAP, ChemMate, CSA, LABC, and SABC techniques. J Clin Pathol. 51:506–511. 1998. View Article : Google Scholar : PubMed/NCBI

12. 

Durie BG and Salmon SE: A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presentingclinical features, response to treatment, and survival. Cancer. 36:842–854. 1975. View Article : Google Scholar : PubMed/NCBI

13. 

Smithers DW: Summary of papers delivered at the Conference on Staging in Hodgkin's Disease (Ann Arbor). Cancer Res. 31:1869–1870. 1971.PubMed/NCBI

14. 

Yang QP, Zhang WY, Yu JB, Zhao S, Xu H, Wang WY, Bi CF, Zuo Z, Wang XQ, Huang J, et al: Subtype distribution of lymphomas in Southwest China: Analysis of 6,382 cases using WHO classification in a single institution. Diagn Pathol. 6:772011. View Article : Google Scholar : PubMed/NCBI

15. 

Gherlinzoni F, Cavo M, Pileri S, Rivano MT, Boriani S, Biagini R and Emiliani E: Solitary plasmocytoma of the bone in a case of Hodgkin's disease. Acta Haematol. 76:178–180. 1986. View Article : Google Scholar : PubMed/NCBI

16. 

Weisenberg E, Anastasi J, Adeyanju M, Variakojis D and Vardiman JW: Hodgkin's disease associated with chronic lymphocytic leukemia. Eight additional cases, including two of the nodular lymphocyte predominant type. Am J Clin Pathol. 103:479–484. 1995. View Article : Google Scholar : PubMed/NCBI

17. 

Chan WC, Griem ML, Grozea PN, Freel RJ and Variakojis D: Mycosis fungoides and Hodgkin's disease occurring in the same patient. Report of three cases. Cancer. 44:1408–1413. 1979. View Article : Google Scholar : PubMed/NCBI

18. 

Harris NL: The relationship between Hodgkin's disease and non-Hodgkin's lymphoma. Semin Diagn Pathol. 9:304–310. 1992.PubMed/NCBI

19. 

Loutayf Ranea JJ: Lymph node plasmacytoma as the 2d tumor in a patient with Hodgkin's disease. Medicina (B Aires). 46:2521986.(In Spanish).

20. 

Berkessy S, Radványi G, Nagy Z and Takács I: A case of multiple myeloma, associated with terminal plasma cell leukemia following recovery from Hodgkin's disease. Orv Hetil. 129:1053–1055. 1988.(In Hungarian). PubMed/NCBI

21. 

Greenberg BB, Stats D and Goldberg M: The simultaneous occurrence of plasma cell multiple myeloma and Hodgkin's disease. N Y State J Med. 50:305–307. 1950.PubMed/NCBI

22. 

Gelmann EP and Dennis LH: Plasma-cell dyscrasia after alkylating-agent therapy for Hodgkin's disease. N Engl J Med. 305:13501981. View Article : Google Scholar : PubMed/NCBI

23. 

Hasskarl J, Ihorst G, De Pasquale D, Schröttner P, Zerweck A, Wäsch R and Engelhardt M: Association of multiple myeloma with different neoplasms: Systematic analysis in consecutive patients with myeloma. Leuk Lymphoma. 52:247–259. 2011. View Article : Google Scholar : PubMed/NCBI

24. 

de Ibarrola Andrés C, Toscano R, Lahuerta JJ and Martínez-González MA: Simultaneous occurrence of Hodgkin's disease, nodal Langerhans' cell histiocytosis and multiple myeloma IgA (kappa). Virchows Arch. 434:259–262. 1999. View Article : Google Scholar : PubMed/NCBI

25. 

Lalayanni C, Theodoridou S, Athanasiadou A, Saloum R and Tsatalas C: Simultaneous occurrence of multiple myeloma and Hodgkin's disease. A case report. Haematologica. 85:772–773. 2000.PubMed/NCBI

26. 

Sundeen J, Lipford E, Uppenkamp M, Sussman E, Wahl L, Raffeld M and Cossman J: Rearranged antigen receptor genes in Hodgkin's disease. Blood. 70:96–103. 1987.PubMed/NCBI

27. 

Bräuninger A, Hansmann ML, Strickler JG, Dummer R, Burg G, Rajewsky K and Küppers R: Identification of common germinal center B-cell precursors in two patients with both Hodgkin's disease and non-Hodgkin's lymphoma. N Engl J Med. 340:1239–1247. 1999. View Article : Google Scholar : PubMed/NCBI

28. 

Ibbotson RM, Revell PA, Molland EA and Minton MJ: The simultaneous presence of Hodgkin's disease and myeloma. Postgrad Med J. 53:52–53. 1977. View Article : Google Scholar : PubMed/NCBI

29. 

Tilly H, Bastard C, Delastre T, Duval C, Bizet M, Lenormand B, Daucé JP, Monconduit M and Piguet H: Cytogenetic studies in untreated Hodgkin's disease. Blood. 77:1298–1304. 1991.PubMed/NCBI

30. 

Lu ZY, Brailly H, Wijdenes J, Bataille R, Rossi JF and Klein B: Measurement of whole body interleukin-6 (IL-6) production: Prediction of the efficacy of anti-IL-6 treatments. Blood. 86:3123–3131. 1995.PubMed/NCBI

31. 

Seymour JF, Talpaz M, Hagermeister FB, Cabanillas F and Kurzrock R: Clinical correlates of elevated serum levels of interleukin-6 in patients with untreated Hodgkin's disease. Am J Med. 102:21–28. 1997. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Huang C, Zhao G, Wang L, Zhang H, Wu X, Zhang M, Ma R, Wang L, Liu Y, Liu L, Liu L, et al: Simultaneous occurrence of Hodgkin's lymphoma and multiple myeloma: A case report and review of the literature. Oncol Lett 11: 4139-4143, 2016.
APA
Huang, C., Zhao, G., Wang, L., Zhang, H., Wu, X., Zhang, M. ... Liu, L. (2016). Simultaneous occurrence of Hodgkin's lymphoma and multiple myeloma: A case report and review of the literature. Oncology Letters, 11, 4139-4143. https://doi.org/10.3892/ol.2016.4503
MLA
Huang, C., Zhao, G., Wang, L., Zhang, H., Wu, X., Zhang, M., Ma, R., Wang, L., Liu, Y., Liu, L."Simultaneous occurrence of Hodgkin's lymphoma and multiple myeloma: A case report and review of the literature". Oncology Letters 11.6 (2016): 4139-4143.
Chicago
Huang, C., Zhao, G., Wang, L., Zhang, H., Wu, X., Zhang, M., Ma, R., Wang, L., Liu, Y., Liu, L."Simultaneous occurrence of Hodgkin's lymphoma and multiple myeloma: A case report and review of the literature". Oncology Letters 11, no. 6 (2016): 4139-4143. https://doi.org/10.3892/ol.2016.4503
Copy and paste a formatted citation
x
Spandidos Publications style
Huang C, Zhao G, Wang L, Zhang H, Wu X, Zhang M, Ma R, Wang L, Liu Y, Liu L, Liu L, et al: Simultaneous occurrence of Hodgkin's lymphoma and multiple myeloma: A case report and review of the literature. Oncol Lett 11: 4139-4143, 2016.
APA
Huang, C., Zhao, G., Wang, L., Zhang, H., Wu, X., Zhang, M. ... Liu, L. (2016). Simultaneous occurrence of Hodgkin's lymphoma and multiple myeloma: A case report and review of the literature. Oncology Letters, 11, 4139-4143. https://doi.org/10.3892/ol.2016.4503
MLA
Huang, C., Zhao, G., Wang, L., Zhang, H., Wu, X., Zhang, M., Ma, R., Wang, L., Liu, Y., Liu, L."Simultaneous occurrence of Hodgkin's lymphoma and multiple myeloma: A case report and review of the literature". Oncology Letters 11.6 (2016): 4139-4143.
Chicago
Huang, C., Zhao, G., Wang, L., Zhang, H., Wu, X., Zhang, M., Ma, R., Wang, L., Liu, Y., Liu, L."Simultaneous occurrence of Hodgkin's lymphoma and multiple myeloma: A case report and review of the literature". Oncology Letters 11, no. 6 (2016): 4139-4143. https://doi.org/10.3892/ol.2016.4503
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team