Hepatoid adenocarcinoma of the lung without production of α-fetoprotein: A case report and review of the literature

Sun,Ji Ning; Zhang,Bao Long; Li,Lin Kun; Yu,Hai Yan; Wang,Bin

doi:10.3892/ol.2016.4559

Hepatoid adenocarcinoma of the lung without production of α-fetoprotein: A case report and review of the literature

Authors:
- Ji Ning Sun
- Bao Long Zhang
- Lin Kun Li
- Hai Yan Yu
- Bin Wang
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Affiliations: Department of Radiology, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China, Department of Radiology, Weifang Maternity and Child Care Hospital, Weifang, Shandong 261011, P.R. China, Medical Imaging Research Institute, Binzhou Medical University, Yantai, Shandong 264003, P.R. China
Published online on: May 13, 2016 https://doi.org/10.3892/ol.2016.4559
Pages: 189-194

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Abstract

Hepatoid adenocarcinoma of the lung (HAL) is a rare type of extrahepatic hepatoid adenocarcinoma. The majority of such cases that have been reported in the English literature have demonstrated elevated serum α‑fetoprotein (AFP) and/or positive AFP expression on histopathological analysis, and have had poor prognoses. The current study reports an extremely rare case of HAL in the right upper lung without AFP production in a 59‑year‑old male patient. The patient underwent radical right upper lobectomy via video assisted thoracoscopic surgery. No signs of local recurrence or distant metastasis have been observed for 23 months after the surgery. The serum AFP level following surgery remained within the normal range. Although the diagnosis of HAL predominantly depends on pathological examination, a review of the literature demonstrates that HAL has certain characteristic features with regard to its clinical and computed tomography findings and prognoses, and clinicians should be aware that clinicians should be aware that monitoring serum AFP levels, as well as CT findings, remains important.

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