xCT expression modulates cisplatin resistance in Tca8113 tongue carcinoma cells

  • Authors:
    • Peng Zhang
    • Wei Wang
    • Zhenhui Wei
    • Li Xu
    • Xuanning Yang
    • Yuanhong Du
  • View Affiliations

  • Published online on: May 16, 2016     https://doi.org/10.3892/ol.2016.4571
  • Pages: 307-314
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Abstract

Tongue squamous cell carcinoma (TSCC), which is a subtype of head and neck cancer, is the most common type of oral cancer. Due to its high recurrence rate and chemoresistance, the average survival rate for patients with TSCC remains unsatisfactory. At present, cisplatin (CDDP) is utilized as the first‑line treatment for numerous solid neoplasms, including TSCC. CDDP resistance develops in the majority of patients; however, the mechanism of such resistance remains unknown. Therefore, the present study aimed to clarify the mechanism of CDDP resistance and attempted to reduce chemoresistance. The results indicated that CDDP significantly increased expression of xCT, which is the light chain and functional subunit of the glutamate/cysteine transporter system xc‑, and a subsequent increase in glutathione (GSH) levels was observed. The present study demonstrated that the upregulation of xCT expression and intercellular GSH levels contributed to CDDP resistance in TSCC cells. Furthermore, xCT suppression, induced by small interfering RNA or pharmacological inhibitors, sensitized TSCC cells to CDDP treatment. In conclusion, the present study revealed that CDDP‑induced xCT expression promotes CDDP chemoresistance, and xCT inhibition sensitizes TSCC cells to CDDP treatment. These results provide a novel insight into the molecular mechanisms involved in TSCC cell chemoresistance.
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July-2016
Volume 12 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhang P, Wang W, Wei Z, Xu L, Yang X and Du Y: xCT expression modulates cisplatin resistance in Tca8113 tongue carcinoma cells. Oncol Lett 12: 307-314, 2016
APA
Zhang, P., Wang, W., Wei, Z., Xu, L., Yang, X., & Du, Y. (2016). xCT expression modulates cisplatin resistance in Tca8113 tongue carcinoma cells. Oncology Letters, 12, 307-314. https://doi.org/10.3892/ol.2016.4571
MLA
Zhang, P., Wang, W., Wei, Z., Xu, L., Yang, X., Du, Y."xCT expression modulates cisplatin resistance in Tca8113 tongue carcinoma cells". Oncology Letters 12.1 (2016): 307-314.
Chicago
Zhang, P., Wang, W., Wei, Z., Xu, L., Yang, X., Du, Y."xCT expression modulates cisplatin resistance in Tca8113 tongue carcinoma cells". Oncology Letters 12, no. 1 (2016): 307-314. https://doi.org/10.3892/ol.2016.4571