Paraneoplastic Cushing's syndrome associated with bronchopulmonary carcinoid tumor in youth: A case report and review of the literature

Li,Wen‑Ya; Liu,Xu‑Dong; Li,Wei‑Nan; Dong,Si‑Yuan; Qu,Xiao‑Han; Gong,Shu‑Lei; Shao,Ming‑Rui; Zhang,Lin

doi:10.3892/ol.2016.4572

Paraneoplastic Cushing's syndrome associated with bronchopulmonary carcinoid tumor in youth: A case report and review of the literature

Authors:
- Wen‑Ya Li
- Xu‑Dong Liu
- Wei‑Nan Li
- Si‑Yuan Dong
- Xiao‑Han Qu
- Shu‑Lei Gong
- Ming‑Rui Shao
- Lin Zhang
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Affiliations: Department of Thoracic Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Rheumatology and Immunology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Pathology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China
Published online on: May 16, 2016 https://doi.org/10.3892/ol.2016.4572
Pages: 69-72
Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Paraneoplastic Cushing's syndrome (CushingPS) caused by bronchopulmonary carcinoid tumors presents a diagnostic challenge for clinicians. The present study reports the case of an 18-year-old male patient presenting with rapid weight gain, polyuria, polydipsia and progressive muscle weakness. Chemical and imaging findings suggested ectopic secretion of adrenocorticotropin. Whole-body 18fluorine-fluorodeoxyglucose (18FDG-PET/CT) positron‑emission tomography revealed an increased uptake of 18FDG‑PET/CT in the right middle lung mass and lobar lymph node. Postoperative pathology confirmed the presence of a typical carcinoid, as well as a lobar lymph node metastasis. The patient underwent a right middle lobectomy with mediastinal lymph node resection, which resulted in symptom clearance, followed by rapid weight loss. No CushingPS or tumor recurrence was observed at the 3-month postoperative follow‑up.

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