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Article

Multidetector computed tomography analysis of benign and malignant nodules in patients with chronic lymphocytic thyroiditis

  • Authors:
    • Caisong Zhu
    • Wei Liu
    • Jun Yang
    • Jing Yang
    • Kangwei Shao
    • Lixin Yuan
    • Hairong Chen
    • Wei Lu
    • Ying Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, P.R. China, Department of Pathology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, P.R. China
  • Pages: 238-242
    |
    Published online on: May 16, 2016
       https://doi.org/10.3892/ol.2016.4585
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Abstract

The aim of the present study was to compare the multidetector computed tomography (MDCT) features of benign and malignant nodules in patients with chronic lymphocytic thyroiditis (CLT). MDCT findings, including the size, solid percentage, calcification, margin, capsule, anteroposterior-transverse diameter ratio as well as the mode and the degree of enhancement of 137 thyroid nodules in 127 CLT cases were retrospectively analyzed. Furthermore, the correlation between MDCT findings and pathological results combined with the CT perfusion imaging was analyzed for the differences between benign and malignant nodules. A total of 77.5% (31/40) of malignant nodules were completely solid, and 33% (32/97) of benign nodules were predominantly cystic. Compared with the benign nodules, micro‑calcification and internal calcification were more frequently observed in the malignant nodules (P<0.05). MDCT features such as ill‑defined margin, absence of capsule or incomplete capsule or homogeneous enhancement were more likely to be present in the malignant nodules (P<0.05). Nevertheless, no significant difference was observed in the enhancement degree at arterial or venous phase between benign and malignant nodules (P>0.05). MDCT features are useful in differentiating the benign and malignant nodules in CLT patients, and it may be essential for a radiologist to review the MDCT characteristics of nodules in the clinical practice.
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1 

Anderson L, Middleton WD, Teefey SA, Reading CC, Langer JE, Desser T, Szabunio MM, Mandel SJ, Hildebolt CF and Cronan JJ: Hashimoto thyroiditis: Part 2, sonographic analysis of benign and malignant nodules in patients with diffuse Hashimoto thyroiditis. AJR Am J Roentgenol. 195:216–222. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Anderson L, Middleton WD, Teefey SA, Reading CC, Langer JE, Desser T, Szabunio MM, Hildebolt CF, Mandel SJ and Cronan JJ: Hashimoto thyroiditis: Part 1, sonographic analysis of the nodular form of Hashimoto thyroiditis. AJR Am J Roentgenol. 195:208–215. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Sakiyama R: Thyroiditis: A clinical review. Am Fam Physician. 48:615–621. 1993.PubMed/NCBI

4 

Mazokopakis EE, Tzortzinis AA, Dalieraki-Ott EI, Tsartsalis AN, Syros PK, Karefilakis CM, Papadomanolaki MG and Starakis IK: Coexistence of Hashimoto's thyroiditis with papillary thyroid carcinoma. A retrospective study. Hormones (Athens). 9:312–317. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Zhang Y, Dai J, Wu T, Yang N and Yin Z: The study of the coexistence of Hashimoto's thyroiditis with papillary thyroid carcinoma. J Cancer Res Clin Oncol. 140:1021–1026. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Zosin I and Balaş M: Clinical, ultrasonographical and histopathological aspects in Hashimoto's thyroiditis associated with malignant and benign thyroid nodules. Endokrynol Pol. 64:255–262. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Reading CC, Charboneau JW, Hay ID and Sebo TJ: Sonography of thyroid nodules: A ‘classic pattern’ diagnostic approach. Ultrasound Q. 21:157–165. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Wang L, Xia Y, Jiang YX, Dai Q and Li XY: Likelihood ratio-based differentiation of nodular Hashimoto thyroiditis and papillary thyroid carcinoma in patients with sonographically evident diffuse hashimoto thyroiditis: Preliminary study. J Ultrasound Med. 31:1767–1775. 2012.PubMed/NCBI

9 

Gul K, Dirikoc A, Kiyak G, Ersoy PE, Ugras NS, Ersoy R and Cakir B: The association between thyroid carcinoma and Hashimoto's thyroiditis: The ultrasonographic and histopathologic characteristics of malignant nodules. Thyroid. 20:873–878. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Cronan JJ: Thyroid nodules: Is it time to turn off the US machines? Radiology. 247:602–604. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Frates MC, Benson CB, Charboneau JW, Cibas ES, Clark OH, Coleman BG, Cronan JJ, Doubilet PM, Evans DB, Goellner JR, et al: Management of thyroid nodules detected at US: Society of radiologists in ultrasound consensus conference statement. Radiology. 237:794–800. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Kim EK, Park CS, Chung WY, Oh KK, Kim DI, Lee JT and Yoo HS: New sonographic criteria for recommending fine-needle aspiration biopsy of nonpalpable solid nodules of the thyroid. AJR Am J Roentgenol. 178:687–691. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Yang GC, Liebeskind D and Messina AV: Ultrasound-guided fine-needle aspiration of the thyroid assessed by Ultrafast Papanicolaou stain: Data from 1135 biopsies with a two-to six-year follow-up. Thyroid. 11:581–589. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Ishigaki S, Shimamoto K, Satake H, Sawaki A, Itoh S, Ikeda M, Ishigaki T and Imai T: Multi-slice CT of thyroid nodules: Comparison with ultrasonography. Radiat Med. 22:346–353. 2004.PubMed/NCBI

15 

Kang HW, No JH, Chung JH, Min YK, Lee MS, Lee MK, Yang JH and Kim KW: Prevalence, clinical and ultrasonographic characteristics of thyroid incidentalomas. Thyroid. 14:29–33. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Anil C, Goksel S and Gursoy A: Hashimoto's thyroiditis is not associated with increased risk of thyroid cancer in patients with thyroid nodules: A single-center prospective study. Thyroid. 20:601–606. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Kim KW, Park YJ, Kim EH, Park SY, Park Do J, Ahn SH, Park Do J, Jang HC and Cho BY: Elevated risk of papillary thyroid cancer in Korean patients with Hashimoto's thyroiditis. Head Neck. 33:691–695. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Repplinger D, Bargren A, Zhang YW, Adler JT, Haymart M and Chen H: Is Hashimoto's thyroiditis a risk factor for papillary thyroid cancer? J Surg Res. 150:49–52. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Fiore E, Rago T, Latrofa F, Provenzale MA, Piaggi P, Delitala A, Scutari M, Basolo F, Di Coscio G, Grasso L, et al: Hashimoto's thyroiditis is associated with papillary thyroid carcinoma: Role of TSH and of treatment with L-thyroxine. Endocr Relat Cancer. 18:429–437. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Rahimi M, Farshchian N, Rezaee E, Shahebrahimi K and Madani H: To differentiate benign from malignant thyroid nodule comparison of sonography with FNAC findings. Pak J Med Sci. 29:77–80. 2013.PubMed/NCBI

21 

Lawrence W and Kaplan BJ: Diagnosis and management of patients with thyroid nodules. J Surg Oncol. 80:157–170. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Khalid AN, Hollenbeak CS, Quraishi SA, Fan CY and Stack BC: The cost-effectiveness of iodine 131 scintigraphy, ultrasonography, and fine-needle aspiration biopsy in the initial diagnosis of solitary thyroid nodules. Arch Otolaryngol Head Neck Surg. 132:244–250. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Mitchell JC, Grant F, Evenson AR, Parker JA, Hasselgren PO and Parangi S: Preoperative evaluation of thyroid nodules with 18FDG-PET/CT. Surgery. 138:1166–1175. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Basharat R, Bukhari MH, Saeed S and Hamid T: Comparison of fine needle aspiration cytology and thyroid scan in solitary thyroid nodule. Patholog Res Int. 2011:7540412011.PubMed/NCBI

25 

Mutlu H, Sivrioglu AK, Sonmez G, Velioglu M, Sildiroglu HO, Basekim CC and Kizilkaya E: Role of apparent diffusion coefficient values and diffusion-weighted magnetic resonance imaging in differentiation between benign and malignant thyroid nodules. Clin Imaging. 36:1–7. 2012.

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Copy and paste a formatted citation
Spandidos Publications style
Zhu C, Liu W, Yang J, Yang J, Shao K, Yuan L, Chen H, Lu W and Zhu Y: Multidetector computed tomography analysis of benign and malignant nodules in patients with chronic lymphocytic thyroiditis. Oncol Lett 12: 238-242, 2016.
APA
Zhu, C., Liu, W., Yang, J., Yang, J., Shao, K., Yuan, L. ... Zhu, Y. (2016). Multidetector computed tomography analysis of benign and malignant nodules in patients with chronic lymphocytic thyroiditis. Oncology Letters, 12, 238-242. https://doi.org/10.3892/ol.2016.4585
MLA
Zhu, C., Liu, W., Yang, J., Yang, J., Shao, K., Yuan, L., Chen, H., Lu, W., Zhu, Y."Multidetector computed tomography analysis of benign and malignant nodules in patients with chronic lymphocytic thyroiditis". Oncology Letters 12.1 (2016): 238-242.
Chicago
Zhu, C., Liu, W., Yang, J., Yang, J., Shao, K., Yuan, L., Chen, H., Lu, W., Zhu, Y."Multidetector computed tomography analysis of benign and malignant nodules in patients with chronic lymphocytic thyroiditis". Oncology Letters 12, no. 1 (2016): 238-242. https://doi.org/10.3892/ol.2016.4585
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu C, Liu W, Yang J, Yang J, Shao K, Yuan L, Chen H, Lu W and Zhu Y: Multidetector computed tomography analysis of benign and malignant nodules in patients with chronic lymphocytic thyroiditis. Oncol Lett 12: 238-242, 2016.
APA
Zhu, C., Liu, W., Yang, J., Yang, J., Shao, K., Yuan, L. ... Zhu, Y. (2016). Multidetector computed tomography analysis of benign and malignant nodules in patients with chronic lymphocytic thyroiditis. Oncology Letters, 12, 238-242. https://doi.org/10.3892/ol.2016.4585
MLA
Zhu, C., Liu, W., Yang, J., Yang, J., Shao, K., Yuan, L., Chen, H., Lu, W., Zhu, Y."Multidetector computed tomography analysis of benign and malignant nodules in patients with chronic lymphocytic thyroiditis". Oncology Letters 12.1 (2016): 238-242.
Chicago
Zhu, C., Liu, W., Yang, J., Yang, J., Shao, K., Yuan, L., Chen, H., Lu, W., Zhu, Y."Multidetector computed tomography analysis of benign and malignant nodules in patients with chronic lymphocytic thyroiditis". Oncology Letters 12, no. 1 (2016): 238-242. https://doi.org/10.3892/ol.2016.4585
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